Abstract:The presence of malignant ascites is a common feature of advanced stage ovarian cancer. During metastasis, as cells detach from the tumor and extravasate into the peritoneal fluid, ovarian cancer cells must adapt to survive the loss of anchorage support and evade anoikis. An important pro-survival adaptation in this context is the ability of tumor cells to increase their antioxidant capacity and restore cellular redox balance. We previously showed that the mitochondrial superoxide dismutase SOD2 is necessary f… Show more
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