Huperzine aggravated neurochemical and volumetric changes induced by D-galactose in the model of neurodegeneration in rats

Melicherčík, Lubomír; Tvrdík, Tomáš; Nováková, Katarína Slobodová; Nemec, Marek; Kaliňák, Michal; Bačiak, Ladislav; Kašparová, Svatava

doi:10.1016/j.neuint.2022.105365

Cited by 2 publications

(2 citation statements)

References 67 publications

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“…The neuroprotective effect of HupA that we expected was confirmed in this experiment, as we administered this drug from the beginning of the experiment. In contrast to our previous study, where we found that the administration of HupA in the D-Gal model is strongly dependent on the application scheme and may even be harmful to the already ongoing neurodegeneration [58].…”

Section: Resultscontrasting

confidence: 99%

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In vivo Volumetric, DTI and ¹H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

Tvrdík,

Melicherčík,

Šebeková

et al. 2023

Measurement Science Review

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The aim of our study was to develop a multimodal experimental protocol for in vivo imaging and metabolic parameters (MRI, DTI and 1H MRS) in an animal model of neurodegeneration. We have successfully developed the protocol for simultaneous DTI/MRI/1H MRS measurement to ensure unaltered conditions for repeatable non-invasive experiments. In this experiment, diffusion tensor imaging, spectroscopic and volumetric “bio-markers” were generated in the brain for the D-galactose model of “age-related dementia”. The hippocampal relative volume, taurine and myo-inositol relative concentrations were found to be significant predictors contributing to the differences between the groups of rats treated with D-galactose in simulated “neurodegeneration”, even in response to the applied Huperzine A therapy.

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Section: Resultscontrasting

confidence: 99%

“…It is clear that the D-Gal metabolic model has limitations depending on the application scheme used [1], [57], [58]. The neuroprotective effect of HupA that we expected was confirmed in this experiment, as we administered this drug from the beginning of the experiment.…”

Section: Resultssupporting

confidence: 71%

In vivo Volumetric, DTI and ¹H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

Tvrdík,

Melicherčík,

Šebeková

et al. 2023

Measurement Science Review

View full text Add to dashboard Cite

show abstract

In vivo Volumetric, DTI and ¹H MRS Rat Brain Analysis for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

Tomáš,

L’ubomír,

Ladislav

et al. 2023

2023 14th International Conference on Measurement

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Huperzine aggravated neurochemical and volumetric changes induced by D-galactose in the model of neurodegeneration in rats

Cited by 2 publications

References 67 publications

In vivo Volumetric, DTI and ¹H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

In vivo Volumetric, DTI and ¹H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

In vivo Volumetric, DTI and ¹H MRS Rat Brain Analysis for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

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Huperzine aggravated neurochemical and volumetric changes induced by D-galactose in the model of neurodegeneration in rats

Cited by 2 publications

References 67 publications

In vivo Volumetric, DTI and 1H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

In vivo Volumetric, DTI and 1H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

In vivo Volumetric, DTI and 1H MRS Rat Brain Analysis for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

Contact Info

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In vivo Volumetric, DTI and ¹H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

In vivo Volumetric, DTI and ¹H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

In vivo Volumetric, DTI and ¹H MRS Rat Brain Analysis for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy