Huntingtin CAG repeat size variations outside the Huntington’s disease complex: associations with depression and anxiety phenotypes and basal ganglia structure
Magdalena Vater,
Nicolas Rost,
Gertrud Eckstein
et al.
Abstract:Huntington's Disease (HD) is strongly associated with psychiatric symptoms, yet, associations between Huntingtin gene (HTT) CAG repeat size variations and psychiatric phenotypes outside the HD complex are still under-investigated. In this genetic case-control study we compared the distribution of HTT CAG repeat sizes in predefined ranges between patients with major depressive disorder (MDD) (n=2136) and anxiety disorders (ANX) (n=493), and healthy controls (CON) (n=1566). We used regression models to study int… Show more
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