Hunger and satiety in anorexia nervosa: fMRI during cognitive processing of food pictures

Santel, Stephanie; Baving, Lioba; Krauel, Kerstin; Münte, Thomas F.; Rotte, Michael

doi:10.1016/j.brainres.2006.07.045

Cited by 166 publications

(164 citation statements)

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“…The parahippocampal gyrus on the other hand is not only part of reward processing but also reward integration (Pelchat, et al, 2004; Small et al, 2001; Tataranni, et al, 1999). The middle temporal gyrus (Santel et al., 2006) and the parahippocampal gyrus (Breiter et al., 1997; Tataranni et al., 1999) are thought to play a crucial role in reward evaluation and feeding behavior as they store information about the energy states of external sensory cues, integrating them with internal organismic needs. Moreover, the extensive activation observed in the lateral occipital cortex (Cuneus and FG) is believed to be associated with the arousing value of food (Santel et al., 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Also within the limbic system, the amygdala and cingulate cortex not only show a positive correlation with hunger but they also display sensitivity to food desirability (Arana et al., 2003; Shin, Zheng, & Berthoud, 2009). For instance the anterior cingulate shows an inverse relation with the desirability of chocolate, higher functional activity for high versus low caloric food, as well as greater activity in satiation compared to hunger (Killgore & Yurgelun‐Todd, 2005; Santel, Baving, Krauel, Munte, & Rotte, 2006; Small, Zatorre, Dagher, Evans, & Jones‐Gotman, 2001). …”

Section: Introductionmentioning

confidence: 99%

“…Within the area of eating disorders, the inferior parietal lobe (IPL) has shown differential activity between anorexic individuals and controls (Santel et al., 2006). This impaired activity of the IPL might represent the fasting state of anorexics as well as a decreased “somatosensory‐gustatory responsiveness” inversely related with the over‐activity of this region observed in obese individuals (Karhunen, Lappalainen, Vanninen, Kuikka, & Uusitupa, 1997; Wang et al., 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the postcentral gyrus of the IPL (BA 1, 2, 3) contains body representation parts such as the tongue, teeth, and lips (Deuchert et al., 2002; Heimer, 1995). The most reactive region of the temporal lobe in hungry versus non‐hungry states is the fusiform gyrus (FG; Fisher, 1994; LaBar et al., 2001; Santel et al., 2006). The FG has been reported to be more responsive in low compared to high calorie food (Killgore & Yurgelun‐Todd, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…(2009) argued that normal individuals compared with obese, showed more activity in the FG when viewing food. Finally, the middle temporal gyrus usually involved in the perception of emotional stimuli has also shown to be responsive to food stimuli in states of satiety (Mourao‐Miranda et al., 2003; Santel et al., 2006). …”

Section: Introductionmentioning

confidence: 99%

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Preliminary fMRI findings concerning the influence of 5‐HTP on food selection

Ioannou

Williams

2016

Brain and Behavior

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ObjectiveThis functional magnetic resonance imaging study was designed to observe how physiological brain states can alter food preferences. A primary goal was to observe food‐sensitive regions and moreover examine whether 5‐HTP intake would activate areas which have been associated with appetite suppression, anorexia, satiety, and weight loss.Methods and ProcedureFourteen healthy male and female participants took part in the study, of which half of them received the supplement 5‐HTP and the rest vitamin C (control) on an empty stomach. During the scanning session, they passively observed food (high calories, proteins, carbohydrates) and nonfood movie stimuli.ResultsWithin the 5‐HTP group, a comparison of food and nonfood stimuli showed significant responses that included the limbic system, the basal ganglia, and the prefrontal, temporal, and parietal cortices. For the vitamin C group, activity was mainly located in temporal and occipital regions. Compared to the vitamin C group, the 5‐HTP group in response to food showed increased activation on the VMPFC, the DLPFC, limbic, and temporal regions. For the 5‐HTP group, activity in response to food high in protein content compared to food high in calories and carbohydrates was located in the limbic system and the right caudomedial OFC, whereas for the vitamin C group, activity was mainly located at the inferior parietal lobes, the anterior cingulate gyri, and the left ventrolateral OFC. Greater responses to carbohydrates and high calorie stimuli in the vitamin C group were located at the right temporal gyrus, the occipital gyrus, the right VLPFC, whereas for the 5‐HTP group, activity was observed at the left VMPFC, the parahippocampal gyrus bilaterally, the occipital lobe, and middle temporal gyri.DiscussionIn line with the hypotheses, 5‐HTP triggered cortical responses associated with healthy body weight as well as cerebral preferences for protein‐rich stimuli. The brain's activity is altered by macronutrients rich or deprived in the body. By reading the organisms physiological states and combining them with memory experiences, it constructs behavioral strategies steering an individual toward or in opposition to a particular food.

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