Hungarian PROMIS-29+2: psychometric properties and population reference values

Jenei, Balázs; Bató, Alex; Mitev, Ariel Zoltán; Brodszky, Valentin; Rencz, Fanni

doi:10.1007/s11136-023-03364-7

Cited by 6 publications

(4 citation statements)

References 67 publications

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“…A cross-sectional online survey was administered involving the Hungarian adult general population aiming for a sample size of 1700 [ 26 , 27 , 33 , 48 ]. Participants were recruited by a panel company in November 2020 and received survey points upon completing the questionnaire which could be redeemed for rewards.…”

Section: Methodsmentioning

confidence: 99%

“…The relative frequency of responses to each domain of each questionnaire was calculated for the entire sample and then determined according to gender and age groups. Notably, for PROMIS-29+2, T-scores were not calculated; these are presented for each domain in a previous publication [ 27 ]. For all three measures, responses to each domain were dichotomized (“no problems” or “any problems”).…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, they can be used to assess the population’s unmet needs and to identify changes in general health status over time and across countries. Currently, Hungarian population norms exist for utility values of the EQ-5D-3L [ 30 ] and 15D generic PAMs [ 31 ], as well as for summary scores or T-scores of the SF-36 [ 32 ] and two PROMIS generic health status measures (PROMIS-29+2 and PROMIS Global Health) [ 27 , 33 ]. The EQ-5D-5L has population reference values established in more than 30 countries [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, presenting population norms for multiple questionnaires from a common sample is rare [ 35 – 37 ], making it a unique opportunity for a comprehensive comparison. Although the Hungarian versions of EQ-5D-5L, PROPr and SF-6D showed good validity [ 26 , 27 , 38 – 47 ], their population norms have not yet been developed. This study therefore primarily aims to develop general population reference values for the EQ-5D-5L, PROPr and SF-6D based on a large sample of the adult general population in Hungary.…”

Section: Introductionmentioning

confidence: 99%

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Population Norms for the EQ-5D-5L, PROPr and SF-6D in Hungary

Nikl,

Janssen,

Jenei

et al. 2024

PharmacoEconomics

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Objectives This study aimed to develop population norms for three preference-accompanied measures [EQ-5D-5L, Patient-Reported Outcomes Measurement Information System (PROMIS)-preference scoring system (PROPr) and Short-Form Six-Dimension (SF-6D)] in Hungary. Methods In November 2020, an online cross-sectional survey was conducted among a representative sample of the Hungarian adult general population ( n = 1631). Respondents completed the Hungarian versions of the EQ-5D-5L, PROMIS-29+2 version 2.1 and 36-item Short Form Survey version 1 (SF-36v1). The association of utilities with sociodemographic and health-related characteristics of respondents was analysed using multivariate regressions. Results The proportion of respondents reporting problems ranged from 8 to 44% (self-care to pain/discomfort) on the EQ-5D-5L, 39–94% (physical function to sleep) on PROPr and 38–87% (role limitations to vitality) on the SF-6D. Problems related to physical function, self-care, usual activities/role limitations and pain increased with age, while mental health problems decreased in all three measures. In almost all corresponding domains, respondents indicated the fewest problems on the EQ-5D-5L and the most problems on the SF-6D. The mean EQ-5D-5L, PROPr and SF-6D utilities were 0.900, 0.535 and 0.755, respectively. Female gender (PROPr, SF-6D), a lower level of education (EQ-5D-5L, PROPr), being unemployed or a disability pensioner (EQ-5D-5L), being underweight or obese (SF-6D), lack of physical exercise (all) and polypharmacy (all) were associated with significantly lower utilities. PROPr yielded the lowest and EQ-5D-5L the highest mean utilities in 28 of 30 chronic health conditions. Conclusions This study presents the first set of Hungarian population norms for the EQ-5D-5L, PROPr and SF-6D. Our findings can serve as reference values in clinical trials and observational studies and contribute to the monitoring of population health and the assessment of disease burden in Hungary. Supplementary Information The online version contains supplementary material available at 10.1007/s40273-024-01360-4.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Population Norms for the EQ-5D-5L, PROPr and SF-6D in Hungary

Nikl,

Janssen,

Jenei

et al. 2024

PharmacoEconomics

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Psychometric properties and general population reference values for PROMIS Global Health in Hungary

et al. 2023

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Objectives Patient-Reported Outcomes Measurement Information System–Global Health (PROMIS-GH) is a widely used generic measure of health status. This study aimed to (1) assess the psychometric properties of the Hungarian PROMIS-GH and to (2) develop general population reference values in Hungary. Methods An online cross-sectional survey was conducted among the Hungarian adult general population (n = 1700). Respondents completed the PROMIS-GH v1.2. Unidimensionality (confirmatory factor analysis and bifactor model), local independence, monotonicity (Mokken scaling), graded response model fit, item characteristic curves and measurement invariance were examined. Spearman’s correlations were used to analyse convergent validity of PROMIS-GH subscales with SF-36v1 composites and subscales. Age- and gender-weighted T-scores were computed for the Global Physical Health (GPH) and Global Mental Health (GMH) subscales using the US item calibrations. Results The item response theory assumptions of unidimensionality, local independence and monotonicity were met for both subscales. The graded response model showed acceptable fit indices for both subscales. No differential item functioning was detected for any sociodemographic characteristics. GMH T-scores showed a strong correlation with SF-36 mental health composite score (rs = 0.71) and GPH T-scores with SF-36 physical health composite score (rs = 0.83). Mean GPH and GMH T-scores of females were lower (47.8 and 46.4) compared to males (50.5 and 49.3) (p < 0.001), and both mean GPH and GMH T-scores decreased with age, suggesting worse health status (p < 0.05). Conclusion This study established the validity and developed general population reference values for the PROMIS-GH in Hungary. Population reference values facilitate the interpretation of patients’ scores and allow inter-country comparisons.

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Comparing EQ-5D-5L, PROPr, SF-6D and TTO utilities in patients with chronic skin diseases

Szabó,

Brodszky,

Rencz

2024

Eur J Health Econ

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Objectives We aim to compare the measurement properties of three indirect (EQ-5D-5L, PROPr, SF-6D) and one direct (time trade-off, TTO) utility assessment methods in patients with chronic skin diseases. Methods 120 patients with physician-diagnosed chronic skin diseases (psoriasis 39%, atopic dermatitis 27%, acne 19%) completed a cross-sectional survey. Respondents completed the EQ-5D-5L, PROMIS-29+2 and SF-36v1 questionnaires and a 10-year TTO task for own current health. Utilities were computed using the US value sets. Ceiling, convergent and known-group validity were compared across the utilities derived with these four methods. Known-groups were defined based on general, physical and mental health. The agreement between utilities was assessed using intraclass correlation coefficients (ICC). Results Mean utilities for the EQ-5D-5L, PROPr, SF-6D and TTO were 0.79, 0.47, 0.76 and 0.89. In corresponding order, the ceiling was 28%, 0%, 2% and 65%. The SF-6D showed excellent agreement with the EQ-5D-5L (ICC = 0.770). PROPr demonstrated poor agreement with the EQ-5D-5L (ICC = 0.381) and fair with SF-6D utilities (ICC = 0.445). TTO utilities showed poor agreement with indirectly assessed utilities (ICC = 0.058–0.242). The EQ-5D-5L better discriminated between known groups of general and physical health, while the SF-6D and PROPr outperformed the EQ-5D-5L for mental health problems. Conclusion There is a great variability in utilities across the four methods in patients with chronic skin conditions. The EQ-5D-5L, despite its higher ceiling, appears to be the most efficient in discriminating between patient groups for physical health aspects. Our findings inform the choice of instrument for quality-adjusted life year calculations in cost-utility analyses.

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Hungarian PROMIS-29+2: psychometric properties and population reference values

Cited by 6 publications

References 67 publications

Population Norms for the EQ-5D-5L, PROPr and SF-6D in Hungary

Population Norms for the EQ-5D-5L, PROPr and SF-6D in Hungary

Psychometric properties and general population reference values for PROMIS Global Health in Hungary

Comparing EQ-5D-5L, PROPr, SF-6D and TTO utilities in patients with chronic skin diseases

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