“…6,7 We now know that the glass lens interfered with the exchange of oxygen and tear fluid behind the lens necessary for corneal health and had too high a modulus for eyelid and corneal comfort. Müller and others correctly theorized that the glass interfered with required corneal and conjunctival functions.…”
In response to patient demands for extended contact lens wearing times, the contact lens industry has developed novel silicone-hydrogel (SiHy) lens materials that combine the enhanced oxygen permeability of silicone polymers with the water-based comfort of conventional hydrogels. In the past 12 years since the successful launch of these SiHy lenses, much has been learned about their ability to provide the biocompatibility necessary to sustain ocular health and comfort. A review of the unique physiologic requirements for a successful extended wear lens and how the first and current SiHy lenses address them is provided.
“…6,7 We now know that the glass lens interfered with the exchange of oxygen and tear fluid behind the lens necessary for corneal health and had too high a modulus for eyelid and corneal comfort. Müller and others correctly theorized that the glass interfered with required corneal and conjunctival functions.…”
In response to patient demands for extended contact lens wearing times, the contact lens industry has developed novel silicone-hydrogel (SiHy) lens materials that combine the enhanced oxygen permeability of silicone polymers with the water-based comfort of conventional hydrogels. In the past 12 years since the successful launch of these SiHy lenses, much has been learned about their ability to provide the biocompatibility necessary to sustain ocular health and comfort. A review of the unique physiologic requirements for a successful extended wear lens and how the first and current SiHy lenses address them is provided.
“…The first two clinical reports of contact lens-wearing trials on humans—conducted independently in the late 1880s by Adolf Fick13 and August Müller14—used conjunctival redness as a measure of the physiological impact of lens wear. Up until the end of the 20th century, limbal and conjunctival redness served as a subtle clinical sign to confirm the sub-clinical inflammatory status of the contact lens-wearing eye.…”
Section: Sub-clinical Manifestations Of Contact Lens-associated Inflamentioning
“…4 Careful inspection of the superficial blood vessels at the limbus reveals the presence of 'anterior limbal loops' (Figure 13.2). In some patients a series of two or three layers of anterior limbal loops can be observed to build on top of each other as the limbal vascular plexus extends towards the cornea, with the vessels constituting each successive inwardly-progressing loop becoming finer and finer.…”
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