Humoral responses of broiler chickens challenged with NDV following supplemental treatment with extracts of Aloe vera , Alma millsoni , Ganoderma lucidum and Archachatina marginata

Ojiezeh, T. I.; Eghafona, N. O.

doi:10.5114/ceji.2015.54590

Cited by 10 publications

(8 citation statements)

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“…3 ). Therefore, the influence of the tested herbal extracts on humoral immunity could not be confirmed despite the fact an increase in the percentage of anti-NDV antibodies after the administration of Aloe vera extract has been reported by other authors [ 26 ]. However, in a study of rabbits, the Aloe vera extract did not influence serum immunoglobulin levels [ 43 ], which is consistent with our findings.…”

Section: Discussionmentioning

confidence: 78%

“…Vahedi et al (2011) reported a higher percentage of CD4 + and CD8 + T cells in the peripheral blood of rabbits receiving Aloe vera extract [ 43 ]. Aloe vera extracts were also found to stimulate humoral immunity in chickens experimentally infected with the Newcastle disease virus (NDV) [ 26 ]. The discussed plant delivers numerous health benefits and exerts anti-inflammatory, antibacterial, antifungal and anti-carcinogenic effects due to the presence of anthraquinones, saccharides and antioxidant vitamins (A, C and E) [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, very little is known about the influence of immunomodulatory herbal extracts on viral infections and immune responses in infected birds. A few studies have been conducted to investigate the immunomodulatory effects of Aloe vera and licorice extracts on birds infected with the avian paramyxovirus serotype-1 (APMV-1), and their results are limited to analyses of antibodies against this virus in chickens [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

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The impact of Aloe vera and licorice extracts on selected mechanisms of humoral and cell-mediated immunity in pigeons experimentally infected with PPMV-1

et al. 2018

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BackgroundThe aim of the study was to evaluate the impact of herbal extracts on selected immunity mechanisms in clinically healthy pigeons and pigeons inoculated with the pigeon paramyxovirus type 1 (PPMV-1). For the first 7 days post-inoculation (dpi), an aqueous solution of Aloe vera or licorice extract was administered daily at 300 or 500 mg/kg body weight (BW). The birds were euthanized at 4, 7 and 14 dpi, and spleen samples were collected during necropsy. Mononuclear cells were isolated from spleen samples and divided into two parts: one part was used to determine the percentage of IgM+ B cells in a flow cytometric analysis, and the other was used to evaluate the expression of genes encoding IFN-γ and surface receptors on CD3+, CD4+ and CD8+ T cells.ResultsThe expression of the IFN-γ gene increased in all birds inoculated with PPMV-1 and receiving both herbal extracts. The expression of the CD3 gene was lowest at 14 dpi in healthy birds and at 7 dpi in inoculated pigeons. The expression of the CD4 gene was higher in uninoculated pigeons receiving both herbal extracts than in the control group throughout nearly the entire experiment with a peak at 7 dpi. A reverse trend was observed in pigeons inoculated with PPMV-1 and receiving both herbal extracts. In uninoculated birds, increased expression of the CD8 gene was noted in the pigeons receiving a lower dose of the Aloe vera extract and both doses of licorice extracts. No significant differences in the expression of this gene were found between inoculated pigeons receiving both herbal extracts. The percentage of IgM+ B cells did not differ between any of the evaluated groups.ConclusionsThis results indicate that Aloe vera and licorice extracts have immunomodulatory properties and can be used successfully to prevent viral diseases, enhance immunity and as supplementary treatment for viral diseases in pigeons.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The impact of Aloe vera and licorice extracts on selected mechanisms of humoral and cell-mediated immunity in pigeons experimentally infected with PPMV-1

et al. 2018

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“…ReishiMax suppressed expression of enzymes and proteins responsible for lipid synthesis, transport and storage: fatty acid synthase (FAS), acyl-CoA synthetase-1 (ACS1), fatty acid binding protein-4 (FABP4), fatty acid transport protein-1 (FATP1) and perilipin, Further RM induced, AMP-activated protein kinase (AMPK) and increased glucose uptake in 3T3-L1 cells by adipocytes. Ganoderma lucidum extracts enhanced the ability to mount humoral responses against viral infection in broiler chickens (Ojiezeh & Eghafona 2015). Chu et al (2007) reported G. lucidum aqueous extract (GLE) on sleep and its sedative activity in a rat model.…”

Section: Other Beneficial Properties Of Ganoderma Lucidummentioning

confidence: 99%

Mycosphere Essays 15. Ganoderma lucidum - are the beneficial medical properties substantiated?

Hapuarachchi¹

2016

Mycosphere

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Ganoderma lucidum, commonly treated as Lingzhi mushroom, is a traditional Chinese medicine which has been widely used over two millennia in Asian countries for maintaining vivacity and longevity. Numerous publications can be found reporting that G. lucidum may possess various beneficial medical properties and contributes to a variety of biological actions by primary metabolites, such as polysaccharides, proteins and triterpenes. Although G. lucidum still remains as a popular agent in commercial products, there is a lack of scientific study on the safety and effectiveness of G. lucidum in humans. There have been some reports of human trials using G. lucidum as a direct control agent for various diseases including arthritis, asthma, diabetes, gastritis, hepatitis, hypertension and neurasthenia, but scientific evidence is still inconclusive. In this paper, we discuss various aspects pertaining to the beneficial medical properties of G. lucidum (excluding anti-cancer activities). In particular, we have addressed some of the loopholes in previous studies that support G. lucidum and its secondary metabolites as effective agents to treat various human diseases. Most of the clinical trials were successful with G. lucidum preparation, however factors like small sample size, lack of a placebo control group, lack of information regarding long term treatment of the drug, age, patient"s gender and side effects, standard method of extraction of G. lucidum, standard dosage, and number of patients treated undermine the validity of the results. Hence, G. lucidum can be used as a therapeutic drug when more direct and supportive scientific evidence are available in near future.

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“…To date, the efficacy of aloe vera and licorice extracts against paramyxovirus infections has been studied only in chickens based on the results of standard laboratory tests evaluating blood biochemical parameters, weight gains, and antibody levels against NDV (Waihenya et al, 2002 ; Ojiezeh and Eghafona, 2015 ; Ojiezeh and Ophori, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

An evaluation of the impact of aloe vera and licorice extracts on the course of experimental pigeon paramyxovirus type 1 infection in pigeons

et al. 2018

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The progressive decrease in the efficiency of synthetic drugs has prompted research into phytogenic feed additives with potentially immunomodulatory and anti-infective properties. Complex diseases with a mixed etiology, including viral, pose a growing problem in domestic pigeons. The aim of this study was to determine the effectiveness of various doses of aloe vera and licorice extracts on the course of experimental PPMV-1 infection in pigeons. The experiment was performed on pigeons divided into 5 groups, including one control group and 4 experimental groups, which were orally administered aloe vera or licorice extracts at 300 or 500 mg/kg BW for 7 d after experimental inoculation with PPMV-1. On d 4, 7, and 14 after inoculation, cloacal swabs and samples of organs were collected from 4 birds in each group. The samples were analyzed to determine the copy number of PPMV-1 RNA by TaqMan qPCR. The results indicate that licorice and aloe vera extracts inhibited PPMV-1 replication by decreasing viral RNA copy numbers in the examined organs. The most inhibitory effect was observed in pigeons receiving aloe vera extract at 300 mg/kg BW, for which PPMV-1 RNA copy numbers were approximately 7-fold lower (brain), 9-fold lower (kidneys), and 14-fold lower (liver) than in the control group. The results of this study point to the potentially antiviral effects of aloe vera and licorice extracts in pigeons infected with PPMV-1. To the best of our knowledge, this is the first study to investigate the antiviral properties of aloe vera and licorice extracts in domestic pigeons.

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Humoral responses of broiler chickens challenged with NDV following supplemental treatment with extracts of Aloe vera , Alma millsoni , Ganoderma lucidum and Archachatina marginata

Cited by 10 publications

References 14 publications

The impact of Aloe vera and licorice extracts on selected mechanisms of humoral and cell-mediated immunity in pigeons experimentally infected with PPMV-1

The impact of Aloe vera and licorice extracts on selected mechanisms of humoral and cell-mediated immunity in pigeons experimentally infected with PPMV-1

Mycosphere Essays 15. Ganoderma lucidum - are the beneficial medical properties substantiated?

An evaluation of the impact of aloe vera and licorice extracts on the course of experimental pigeon paramyxovirus type 1 infection in pigeons

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