Humoral Regulation of Erythropoiesis and Thrombopoiesis in Appropriate and Small for Gestational Age Infants

Meberg, Alf; Jakobsen, E.; Halvorsen, Karin

doi:10.1111/j.1651-2227.1982.tb09517.x

Cited by 30 publications

(13 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Compared to AGA, SGA NBs had higher hemoglobin and hematocrit levels, lower white cells - except lymphocytes and basophils - and lower number of platelets. Studies suggest that increased erythropoiesis and reduced white cells are associated with prolonged exposure to hypoxia 20 21 It is suggested that frequent placental infarctions with platelet consumption may lead to thrombocytopenia and polycythemia, and that preeclampsia and chronic hypertension may play a role in the genesis of thrombocytopenia 5 …”

Section: Discussionmentioning

confidence: 99%

Blood Cells Profile in Umbilical Cord of Late Preterm and Term Newborns

Rolim

Lambert

Borges

et al. 2019

Rev. paul. pediatr.

View full text Add to dashboard Cite

Objective: To describe the hematological profile in cord blood of late preterm and term newborns and compare blood indices according to sex, weight for gestational age and type of delivery.Methods: Cross-sectional study with late preterm and term newborns in a second-level maternity. Multiple gestation, chorioamnionitis, maternal or fetal hemorrhage, suspected congenital infection, 5-minute Apgar <6, congenital malformations, and Rh hemolytic disease were excluded. Percentiles 3, 5,10, 25, 50, 75, 90, 95 and 97 of blood indices were calculated for both groups.Results: 2,662 newborns were included in the sample, 51.1% males, 7.3% late preterms, 7.8% small for gestational age (SGA) and 81.2% adequate for gestational age (AGA). Mean gestational age was 35.6±1.9 and 39.3±1.0 weeks, respectively, for premature and term neonates. The erythrocytes indices and white blood cells increased from 34-36.9 to 37-41.9 weeks. Basophils and platelets remained constant during gestation. Premature neonates presented lower values of all blood cells, except for lymphocytes and eosinophils. SGA neonates presented higher values of hemoglobin, hematocrit and lower values of leukocytes, neutrophils, bands, segmented, eosinophils, monocytes and platelets. Male neonates presented similar values of erythrocytes and hemoglobin and lower leukocytes, neutrophils, segmented and platelets. Neonates delivered by C-section had lower values of red blood cells and platelets. Chronic or gestational hypertension induced lower number of platelets.Conclusions: Blood cells increased during gestation, except for platelets and basophils. SGA neonates had higher hemoglobin and hematocrit values and lower leukocytes. Number of platelets was smaller in male SGAs, born by C-section and whose mothers had hypertension.

show abstract

Section: Discussionmentioning

confidence: 99%

Blood Cells Profile in Umbilical Cord of Late Preterm and Term Newborns

Rolim

Lambert

Borges

et al. 2019

Rev. paul. pediatr.

View full text Add to dashboard Cite

show abstract

“…In our study, the mean normoblast count in the SGA group normalized within 7 days, which is within the 3–12 days that was reported for the premature SGA babies in the above‐mentioned investigation. So far, two studies have linked findings of increased Hb, Hct, and RBC count on day 1 of life in SGA babies with stimulation of fetal erythropoiesis due to long‐term exposure to hypoxia (Meberg, Jakobsen & Halvorsen, 1982; Philip & Tito, 1989). Other work has demonstrated a negative correlation between Apgar score (a measure of hypoxia) and Hct (De Grauw et al.…”

Section: Discussionmentioning

confidence: 99%

Complete blood count parameters for healthy, small-for-gestational-age, full-term newborns

et al. 2006

View full text Add to dashboard Cite

No previous study has investigated the full range of complete blood count (CBC) parameters in small-for-gestational-age (SGA) newborns. The main aim of this study was to compare CBC and peripheral smear parameters in term, healthy SGA neonates and appropriate-for-gestational-age (AGA) neonates, and to establish CBC reference values for full-term SGA newborns. One hundred thirty-two healthy, term newborns (73 SGA and 59 AGA) were included. On day 1, we obtained 109 samples and on day 7 we obtained 77 samples. A CBC and peripheral smear were analyzed for each sample collected and group data were compared. We observed higher mean values for normoblast count, hemoglobin, hematocrit, and red blood cell (RBC) count in the SGA babies than in the AGA babies on day 1. The mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration values for the SGA babies were decreased because of the relatively high RBC count and relatively high mean corpuscular volume we observed in this group. Of the SGA newborns, 21.9% had neutropenia and 4.7% had absolute neutrophil counts lower than 1500/microl on day 1. On both day 1 and day 7, the SGA newborns had higher mean absolute metamyelocyte counts and higher mean I : T (immature : total neutrophil ratio) values than the AGA group. The SGA babies had a lower mean absolute lymphocyte count on day 7 than the AGA group. We detected thrombocytopenia in almost one-third of the 64 SGA newborns tested on day 1. In summary, our study clearly demonstrates that CBC parameters for healthy, full-term, SGA newborns are different from those of healthy, term AGA newborns. This is the first study that has documented different mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, metamyelocyte counts, lymphocyte counts, and I : T in SGA babies compared with AGA babies.

show abstract

“…78 In neonates with intrauterine growth restriction, thrombocytopenia may be present. 79 It is much more common in preterm than in term newborn infants. 1,79,80 It is basically caused by a decreased platelet production, but may also result from increased destruction secondary to intrauterine hypoxia or anti-human leukocyte antigen (anti-HLA) antibodies.…”

Section: Giant Hemangiomamentioning

confidence: 99%

“…79 It is much more common in preterm than in term newborn infants. 1,79,80 It is basically caused by a decreased platelet production, but may also result from increased destruction secondary to intrauterine hypoxia or anti-human leukocyte antigen (anti-HLA) antibodies. 5,[81][82][83][84] Thrombocytopenia develops in the first days; it is moderate and generally does not last more than 2 weeks.…”

Section: Giant Hemangiomamentioning

confidence: 99%

Neonatal thrombocytopenia: A review. II. Non-immune thrombocytopenia; platelet transfusion

2021

Arch Argent Pediat

View full text Add to dashboard Cite

Non-immune thrombocytopenia is caused by multiple pathologies; the most common causes are extra-or intrauterine infections, whereas secondary cases result from other pathologies involved in the fetal-placentalmaternal interface. This second article lists its causes and provides details of the different pathologies. Platelet transfusion is widely used in neonatology, both as treatment and as bleeding prophylaxis. However, there is no general consensus about the platelet count threshold that is convenient to indicate a transfusion or actual indications. Recent articles are commented regarding the different proposed strategies. The emphasis is on discussing the multiple adverse effects of platelet transfusions because knowledge about them is changing the paradigm for indications, suggesting that a much more restrictive policy is required.

show abstract

Humoral Regulation of Erythropoiesis and Thrombopoiesis in Appropriate and Small for Gestational Age Infants

Cited by 30 publications

References 18 publications

Blood Cells Profile in Umbilical Cord of Late Preterm and Term Newborns

Blood Cells Profile in Umbilical Cord of Late Preterm and Term Newborns

Complete blood count parameters for healthy, small-for-gestational-age, full-term newborns

Neonatal thrombocytopenia: A review. II. Non-immune thrombocytopenia; platelet transfusion

Contact Info

Product

Resources

About