Abstract:Mass vaccination with vaccinia virus resulted in smallpox eradication, that was later cancelled due to potential of developing severe complications. Reappraisal of scientific interest to smallpox vaccine was accounted for by emerged threat of using relevant virus as a bioweapon as well as increased frequency of orthopoxvirus infections paralleled with decline in population immunity. The vaccinia virus is also used as a vector for generating recombinant vaccines. Understanding mechanisms behind formation of imm… Show more
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