Humoral Immunity

Kozel, Thomas R.; Lupan, David M.

doi:10.1007/978-3-662-10373-9_4

Human and Animal Relationships 1996

DOI: 10.1007/978-3-662-10373-9_4

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Humoral Immunity

Thomas R. Kozel

David M. Lupan

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2007

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“…The role of the recently described thrombin pathway (10) for immune defense needs to be worked out. C. albicans activates both the alternative and classical pathways of complement (11). C3b molecules bind directly to the C. albicans surface or via mannan-specific IgG antibodies, which occur naturally in human serum (12).…”

mentioning

confidence: 99%

Gpm1p Is a Factor H-, FHL-1-, and Plasminogen-binding Surface Protein of Candida albicans

Poltermann

Kunert

Heide

et al. 2007

Journal of Biological Chemistry

117

128

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CaGpm1p is a surface protein as demonstrated by immunostaining and flow cytometry. A C. albicans gpm1؊/؊ mutant strain was generated that did not grow on glucose-supplemented but on ethanol-and glycerol-supplemented medium. Reduced binding of Factor H and plasminogen to the null mutant strain is in agreement with the presence of additional binding proteins. Attached to CaGpm1p, each of the three host plasma proteins is functionally active. Factor H and FHL-1 show cofactor activity for cleavage of C3b, and bound plasminogen is converted by urokinase-type plasminogen activator to proteolytically active plasmin. Thus, the surface-expressed CaGpm1p is a virulence factor that utilizes the host Factor H, FHL-1, and plasminogen for immune evasion and degradation of extracellular matrices.

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mentioning

confidence: 99%

Gpm1p Is a Factor H-, FHL-1-, and Plasminogen-binding Surface Protein of Candida albicans

Poltermann

Kunert

Heide

et al. 2007

Journal of Biological Chemistry

117

128

View full text Add to dashboard Cite

show abstract

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Humoral Immunity

Cited by 1 publication

References 152 publications

Gpm1p Is a Factor H-, FHL-1-, and Plasminogen-binding Surface Protein of Candida albicans

Gpm1p Is a Factor H-, FHL-1-, and Plasminogen-binding Surface Protein of Candida albicans

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