Humoral Immune Response Kinetics in Philander opossum and Didelphis marsupialis Infected and Immunized by Trypanosoma cruzi Employing an Immunofluorescence Antibody Test

Legey, Ana Paula; Pinho, Ana Paula; Xavier, Samanta Cristina das Chagas; Leon, Leonor L.; Jansen, Ana Maria

doi:10.1590/s0074-02761999000300016

Cited by 15 publications

(12 citation statements)

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“…These investigators showed that isolates obtained from the marsupial Philander frenata were more virulent for Swiss mice than isolates from Didelphis marsupialis, suggesting that the biological characteristics of the parasite may differ depending on the host from which it was isolated. Other authors also observed peculiarities in the interaction between T. cruzi subpopulations and these two Didelphidae and considered D. marsupialis a strict "biological filter" (Legey et al 1999). These findings are also supported by those of Mangia et al (2001) and Fernandes et al (1999), who observed a strong association between hosts and a particular parasite genotype.…”

Section: Discussionsupporting

confidence: 59%

Infectivity for mice of Trypanosoma cruzi I and II strains isolated from different hosts

et al. 2006

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In this paper, the infectivity for mice of Trypanosoma cruzi I and II strains isolated from sylvatic animals, triatomines, and humans is determined using fresh blood examination, hemoculture, culture of macerated organs, and polymerase chain reaction (PCR). Six strains were considered to have low infectivity (9.1-18.2%), five medium (27.3-45.4%), and one high (100.0%). Infectivity of T. cruzi strains isolated from sylvatic animals was significantly higher than that of strains isolated from humans and triatomines (p=0.0141). No significant difference was observed between the infectivity of T. cruzi I and II strains. The parasite was detected by fresh blood examination in one strain, by hemoculture and culture of macerated organs in four strains, and by PCR in all strains. We conclude that the infectivity is related to the host from which the strains were isolated, but the infectivity is not related to the genetic group of the parasite. We also conclude that the majority of the strains studied have low and medium infectivity for mice, and that PCR is an important tool to detect T. cruzi in strains with this biological characteristic.

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Section: Discussionsupporting

confidence: 59%

Infectivity for mice of Trypanosoma cruzi I and II strains isolated from different hosts

et al. 2006

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“…The genus Philander also displays a more severe inflammatory response to T. cruzi (162,163). Experimental inoculation of Monodelphis domestica with TcI, TcII, and TcVI strains resulted in infections, but a North American TcIV isolate failed to establish an infection (242).…”

Section: Fig 4 Reports Of Natural Trypanosoma Cruzi Infection In Umentioning

confidence: 99%

Trypanosoma cruzi and Chagas' Disease in the United States

et al. 2011

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SUMMARY Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi and causes potentially life-threatening disease of the heart and gastrointestinal tract. The southern half of the United States contains enzootic cycles of T. cruzi , involving 11 recognized triatomine vector species. The greatest vector diversity and density occur in the western United States, where woodrats are the most common reservoir; other rodents, raccoons, skunks, and coyotes are also infected with T. cruzi. In the eastern United States, the prevalence of T. cruzi is highest in raccoons, opossums, armadillos, and skunks. A total of 7 autochthonous vector-borne human infections have been reported in Texas, California, Tennessee, and Louisiana; many others are thought to go unrecognized. Nevertheless, most T. cruzi -infected individuals in the United States are immigrants from areas of endemicity in Latin America. Seven transfusion-associated and 6 organ donor-derived T. cruzi infections have been documented in the United States and Canada. As improved control of vector- and blood-borne T. cruzi transmission decreases the burden in countries where the disease is historically endemic and imported Chagas' disease is increasingly recognized outside Latin America, the United States can play an important role in addressing the altered epidemiology of Chagas' disease in the 21st century.

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“…Na natureza, as cuícas Philander frenatus e P. opossum também podem assumir um papel importante na manutenção e infecção de triatomíneos, uma vez que são encontradas altas prevalên-cias de infecção com hemocultivos positivos que podem chegar a 80%. Ao contrário de D. aurita, a infecção experimental de P. frenatus resultou em altas parasitemias e altos títulos de anticorpos quando infectadas por ambos os genótipos TCI e TCII do parasito (Legey et al 1999). O perfil das infecções experimentais de D. aurita e P. frenatus mostra que essas espécies podem ser responsáveis por distintas pressões seletivas para as sub-populações de T. cruzi e, assim, desempenhar papéis diferentes na transmissão do parasito na natureza.…”

Section: Ordem Marsupialiaunclassified

Vetores da doença de Chagas no Brasil

Galvão¹

2014

117

107

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Humoral Immune Response Kinetics in Philander opossum and Didelphis marsupialis Infected and Immunized by Trypanosoma cruzi Employing an Immunofluorescence Antibody Test

Cited by 15 publications

References 12 publications

Infectivity for mice of Trypanosoma cruzi I and II strains isolated from different hosts

Infectivity for mice of Trypanosoma cruzi I and II strains isolated from different hosts

Trypanosoma cruzi and Chagas' Disease in the United States

Vetores da doença de Chagas no Brasil

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