Humoral Immune Response in <i>Yersinia enterocolitica</i> O:5 Induced Arthritis in Hamsters

Genaro, María Silvia Di; Escudero, María Esther; Velázquez, Lidia del Carmen; Muñoz, Estela M.; Aguilera, Claudia; Juárez, Américo; Scardapane, Luis; Guzmán, A.M.

doi:10.1111/j.1348-0421.1997.tb01900.x

Cited by 5 publications

(2 citation statements)

References 30 publications

(19 reference statements)

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“…The prolonged persistence of Yersinia antigens in synovial cells may be a primary cause of maintenance of in£ammatory host responses in the joints of patients with reactive arthritis due to Yersinia infection [15]. Recent studies of many authors [5,8,9,11,12,27,29] contribute to the elucidation of mechanisms for the development of reactive arthritis. The structures found in the synovial £uid phagocytes of patients with reactive arthritis after Yersinia infection have usually been the LPS characteristic of the causative bacterium [14].…”

Section: Introductionmentioning

confidence: 99%

Persistence and in vivo effects of Yersinia enterocolitica 0:3 endotoxin in rats

Markova¹

1999

FEMS Immunology and Medical Microbiology

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In vivo effects of Yersinia enterocolitica 0:3 lipopolysaccharide (prepared from bacteria grown at 25 degrees C and 37 degrees C) were investigated after intraperitoneal (i.p.) and intraarticular (i.a.) injection in rats during 30 days of examination. The persistence of endotoxin in the peritoneal and the synovial cavities was demonstrated by the immunofluorescence technique. Peritoneal and synovial exudative cell infiltration, as well as changes in some parameters (glycolytic and acid phosphatase activity, and killing ability of peritoneal cells; lactate dehydrogenase concentration in synovial fluid) were studied. The results indicated that endotoxin could persist longer in the synovial than in the peritoneal cavity.

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Section: Introductionmentioning

confidence: 99%

Persistence and in vivo effects of Yersinia enterocolitica 0:3 endotoxin in rats

Markova¹

1999

FEMS Immunology and Medical Microbiology

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“…The prolonged persistence of Yersinia antigens in synovial cells may be a primary cause of maintenance of inflammatory host responses in the joints of patients with reactive arthritis due to Yersinia infection [15]. Recent studies of many authors [5,8,9,11,12,27,29] contribute to the elucidation of mechanisms for the development of reactive arthritis. The structures found in the synovial fluid phagocytes of patients with reactive arthritis after Yersinia infection have usually been the LPS characteristic of the causative bacterium [14].…”

Section: Introductionmentioning

confidence: 99%

Persistence and in vivo effects ofYersinia enterocolitica0:3 endotoxin in rats

Маркова

Radoucheva

Kussovski

et al. 1999

FEMS Immunology &Amp; Medical Microbiology

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Arthritogenicity ofYersinia enterocolitica O:8 in Hamsters: Analysis of the immune response

et al. 1998

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An animal model, hamster, was used for the study of Yersinia-induced arthritis. The development of arthritis, estimated by measuring the inflammation on hind paws after infection, was correlated with the kinetics of the immune response. Histological and immunofluorescence (IFI) studies and serum antibody measurements were performed. Two inflammatory peaks were observed: an acute one on day 11 post-infection (p.i.) and a chronic one on days 26-35 p.i. Joint cultures were positive until day 14 p.i. IFI was used to demonstrate the deposit of bacterial antigens in the joint. A persistent response of cellular extract-specific IgG antibodies was observed until day 94. Lipopolysaccharide-specific IgG was statistically significant on day 26 p.i. Antibodies against bands 66 and 54 were observed by immunoblotting. Polyclonal activation was detected during reactive arthritis. It is shown that Y. enterocolitica is arthritogenic in hamsters, immune mechanisms participating in the development of this disease.

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Humoral Immune Response in Yersinia enterocolitica O:5 Induced Arthritis in Hamsters

Abstract: and that both autoimmune mechanisms and Yersinia-specific antibodies participated in the development of Yersinia-induced reactive arthritis in the animal model studied.

Cited by 5 publications

References 30 publications

Persistence and in vivo effects of Yersinia enterocolitica 0:3 endotoxin in rats

Persistence and in vivo effects of Yersinia enterocolitica 0:3 endotoxin in rats

Persistence and in vivo effects ofYersinia enterocolitica0:3 endotoxin in rats

Arthritogenicity ofYersinia enterocolitica O:8 in Hamsters: Analysis of the immune response

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