Humoral Hypothalamic Control of Anterior Pituitary: A Study With Combined Tissuecultures

Guillemin, Roger; Rosenberg, B.

doi:10.1210/endo-57-5-599

Cited by 362 publications

(118 citation statements)

References 3 publications

(2 reference statements)

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“…HPA axis activity is mediated by multiple central and peripheral inputs converging on the paraventricular nucleus of the hypothalamus (PVH), where corticotropinreleasing hormone (CRH) is synthesized before its regulated release from the median eminence into the hypophyseal portal circulation (Guillemin and Rosenberg, 1955;Spiess et al, 1981). This stimulates the release of adrenocorticotropin (ACTH) from the anterior lobe of the pituitary, which in turn acts on the adrenal cortex to trigger the release of glucocorticoids, such as corticosterone/cortisol (CORT), into the bloodstream.…”

Section: Introductionmentioning

confidence: 99%

Serotonin Activates the Hypothalamic-Pituitary-Adrenal Axis via Serotonin 2C Receptor Stimulation

Heisler¹,

Pronchuk²,

Nonogaki³

et al. 2007

Journal of Neuroscience

252

169

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Section: Introductionmentioning

confidence: 99%

Serotonin Activates the Hypothalamic-Pituitary-Adrenal Axis via Serotonin 2C Receptor Stimulation

Heisler¹,

Pronchuk²,

Nonogaki³

et al. 2007

Journal of Neuroscience

252

169

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“…The first CRH, per se, purified from sheep hypothalami was described in a work published by Wylie Vale and associates in 1981, well after the initial evidence that provided its existence in 1955 was reported (Guillemin & Rosenberg 1955, Schally & Saffran 1955. However, a few years before the report of the CRH structure, Montecucchi et al (1979) identified the structure of sauvagine (SVG), a 41-kDa peptide isolated from the skin of neotropical frog (Phyllomedusa sauvagei).…”

Section: Discovery Evolution and Function Of Crh Peptidesmentioning

confidence: 98%

MOLECULAR EVOLUTION OF GPCRS: CRH/CRH receptors

Lovejoy¹,

Chang²,

Lovejoy³

et al. 2014

Journal of Molecular Endocrinology

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Corticotrophin-releasing hormone (CRH) is the pivotal neuroendocrine peptide hormone associated with the regulation of the stress response in vertebrates. However, CRH-like peptides are also found in a number of invertebrate species. The origin of this peptide can be traced to a common ancestor of lineages leading to chordates and to arthropods, postulated to occur some 500 million years ago. Evidence indicates the presence of a single CRH-like receptor and a soluble binding protein system that acted to transduce and regulate the actions of the early CRH peptide. In vertebrates, genome duplications led to the divergence of CRH receptors into CRH1 and CRH2 forms in tandem with the development of four paralogous ligand lineages that included CRH; urotensin I/urocortin (Ucn), Ucn2 and Ucn3. In addition, taxon-specific genome duplications led to further local divergences in CRH ligands and receptors. Functionally, the CRH ligand-receptor system evolved initially as a molecular system to integrate early diuresis and nutrient acquisition. As multicellular organisms evolved into more complex forms, this ligand-receptor system became integrated with the organismal stress response to coordinate homoeostatic challenges with internal energy usage. In vertebrates, CRH and the CRH1 receptor became associated with the hypothalamo-pituitary-adrenal/interrenal axis and the initial stress response, whereas the CRH2 receptor was selected to play a greater role in diuresis, nutrient acquisition and the latter aspects of the stress response.

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“…Neurosci. 9:122. doi: 10.3389/fnins.2015.00122 Energy metabolism and behavior in the corticotropin-releasing factor family of peptides This year, 2015, will mark the sixtieth anniversary of the seminal work by Guillemin and Rosenberg (1955) and Schally and Saffran (1955) which, along with the earlier work from Geoffrey Harris' lab, initiated the search for an adrenocorticotropin releasing factor that culminated with the discovery of corticotropin-releasing factor (CRF) in 1981 by Wylie Vale's laboratory (Vale et al, 1981). Since the 1980s, the CRF story has had many twists and turns from the finding that CRF and its receptors are located in many extra-hypothalamic brain areas and extending to the discovery that two genome duplications expanded the CRF peptide family hundreds of millions of years ago.…”

Section: Citationmentioning

confidence: 99%

Energy Metabolism and Behavior in the Corticotropin-Releasing Factor Family of Peptides

2015

Frontiers Research Topics

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Citation:Carr JA and Lovejoy DA (2015) Energy metabolism and behavior in the corticotropin-releasing factor family of peptides. Front. Neurosci. 9:122. doi: 10.3389/fnins.2015.00122 Energy metabolism and behavior in the corticotropin-releasing factor family of peptides This year, 2015, will mark the sixtieth anniversary of the seminal work by Guillemin and Rosenberg (1955) and Schally and Saffran (1955) which, along with the earlier work from Geoffrey Harris' lab, initiated the search for an adrenocorticotropin releasing factor that culminated with the discovery of corticotropin-releasing factor (CRF) in 1981 by Wylie Vale's laboratory (Vale et al., 1981). Since the 1980s, the CRF story has had many twists and turns from the finding that CRF and its receptors are located in many extra-hypothalamic brain areas and extending to the discovery that two genome duplications expanded the CRF peptide family hundreds of millions of years ago. Because of the early metazoan ancestry of CRF, this peptide has become ensconced in a number physiological processes. We now know that stress in vertebrates is comprised of a complex set of physiological actions that regulate organismal metabolism to promote protection of the individual and progeny from life-threatening situations. This stress response likely evolved before the earliest multicellular organisms yet has been retained throughout metazoan evolution. Vertebrates, in particular, have developed some of the most complex stress-regulating mechanisms. Integral to this stress response is CRF, and its paralogue, urocortin (urotensin-I/sauvagine) and a parallel paralogous lineage consisting of urocortin 2 and 3.Six review papers in this volume summarize some of the latest research on the role of CRF and urocortin (UCN) peptides in modulating behavior during stress. In addition, two new research studies present data supporting an ancient role for CRF/UCN receptors in social behavior and feeding, while two additional papers explore the role of extrahypothalamic CRF neurons in behavioral and endocrine responses.A consistent theme running through this set of papers is that many of the effects of CRF/UCN peptides on physiology and behavior are evolutionarily conserved. In their contribution, Chen et al. (2013) examine the evolutionary origins of the tenuerin C-terminal associated peptides (TCAP), peptides which may have predated the origin of the CRF peptide family. Chen et al. (2013) review data on the neuromodulatory actions of TCAP-1 and both its direct and indirect effects as an indirect modulator of CRF intracellular signaling.Feeding and intake of nutrients is essential for the success of any species. A stress-response, as regulated by the CRF family of peptides, generally has suppressive actions on appetite and digestion in order to shunt energy from a parasympathetic need to arousal and sympathetic requirements. From an evolutionary point of view this may be an adaptive response when an animal is threatened by a threat in its environment, however there are obvious energe...

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Humoral Hypothalamic Control of Anterior Pituitary: A Study With Combined Tissuecultures

Cited by 362 publications

References 3 publications

Serotonin Activates the Hypothalamic-Pituitary-Adrenal Axis via Serotonin 2C Receptor Stimulation

Serotonin Activates the Hypothalamic-Pituitary-Adrenal Axis via Serotonin 2C Receptor Stimulation

MOLECULAR EVOLUTION OF GPCRS: CRH/CRH receptors

Energy Metabolism and Behavior in the Corticotropin-Releasing Factor Family of Peptides

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