Humoral Effects of Metastasising Carcinoid Tumours

Snow, P.J.D.; Lennard-Jones, J E; Curzon, G.; Stacey, R. S.

doi:10.1016/s0140-6736(55)93431-0

Cited by 132 publications

(23 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the last of these the estimation of creatinine as well as H.I.A.A. was introduced, following the principle of Snow et al (1955) was investigated in some detail, and fully confirmed, without any specific cause being found; however, adequate dilution appeared to provide a practical solution to the problem and the method described in the previous section of taking a fixed fraction of the urine specimen was finally adopted.…”

Section: Experimental Results Of Preliminary Investigationsmentioning

confidence: 99%

Effect of Reserpine in Therapeutic Dosage on Excretion of 5-Hydroxyindoleacetic Acid

Todrick¹,

Dick²,

Tait³

1958

BMJ

View full text Add to dashboard Cite

Section: Experimental Results Of Preliminary Investigationsmentioning

confidence: 99%

Effect of Reserpine in Therapeutic Dosage on Excretion of 5-Hydroxyindoleacetic Acid

Todrick¹,

Dick²,

Tait³

1958

BMJ

View full text Add to dashboard Cite

“…These tumours, which have low serotonin levels, frequently secrete the serotonin precursor 5-hydroxytryptophan (5-HTP). This produces the 'atypical' symptoms seen in foregut carcinoids with more intense and protracted purplish flushing; the limbs as well as the upper trunk are often affected and frequently result in telangiectasia (Snow et al 1955, Sandler & Snow 1958, Vinik 2001.…”

Section: Carcinoidmentioning

confidence: 99%

Neuroendocrine tumours.

Barakat¹,

Meeran²,

Bloom³

2004

Endocr Relat Cancer

209

111

View full text Add to dashboard Cite

Neuroendocrine tumours are a heterogeneous group including, for example, carcinoid, gastroenteropancreatic neuroendocrine tumours, pituitary tumours, medullary carcinoma of the thyroid and phaeochromocytomas. They have attracted much attention in recent years, both because they are relatively easy to palliate and because they have indicated the chronic effect of the particular hormone elevated. As neuroendocrine phenotypes became better understood, the definition of neuroendocrine cells changed and is now accepted as referring to cells with neurotransmitter, neuromodulator or neuropeptide hormone production, dense-core secretory granules, and the absence of axons and synapses. Neuroendocrine markers, particularly chromogranin A, are invaluable diagnostically. Study of several neuroendocrine tumours has revealed a genetic etiology, and techniques such as genetic screening have allowed risk stratification and prevention of morbidity in patients carrying the particular mutation. Pharmacological therapy for these often slow-growing tumours, e.g. with somatostatin analogues, has dramatically improved symptom control, and radiolabelled somatostatin analogues offer targeted therapy for metastatic or inoperable disease. In this review, the diagnosis and management of patients with carcinoid, gut neuroendocrine tumours, multiple endocrine neoplasia types 1 and 2, and isolated phaeochromocytoma are evaluated.

show abstract

“…An active chronic ulcer was present in the duodenum. Portions of the tumour tissue were biopsied and the histological diagnosis of carcinoid tumour was confirmed (Snow, Lennard-Jones, Curzon, and Stacey, 1955).…”

Section: Case Reportmentioning

confidence: 99%