Humoral Control of Airways*

Said, Sami I.; Kitamura, Satoshi; Yoshida, Tatsuyuki; Preskitt, John T.; Holden, Lise

doi:10.1111/j.1749-6632.1974.tb28205.x

Cited by 61 publications

(14 citation statements)

References 20 publications

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“…5-Hydroxytryptamine (5-HT) is a potent bronchoconstrictor [27] which has been reported to contract isolated cat trachea and to cause rhythmic contractions [28]. In the present study, 5-HT caused contractions of cat bronchus and trachea but no rhythmic contractions.…”

Section: Discussionmentioning

confidence: 47%

Atypical (relaxant) response to histamine in cat bronchus

Chand

Eyre

1977

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Histamine, 2-methylhistamine (a specific H1-receptor agonist), 4-methylhistamine (a specific H2-receptor agonist), isoprenaline, bradykinin, prostaglandin E1, E2, and F 2alpha induce relaxation of carbachol-contracted isolated cat bronchial strips and tracheal chains. Bovine SRS-A contracts bronchus but not trachea. Histamine-induced relaxation of cat bronchus is not blocked by mepyramine (a specific H1-receptor antagonist); metiamide or burimamide (specific H2-receptor antagonists); propranolol ( a beta-adrenoceptor blocker) and indomethacin (a PG-synthetase inhibitor) suggesting non-participation of H1,H2-histamine receptors, beta-adrenoceptors (catecholamine release) and prostaglandin release in histamine-induced broncho-relaxations in the cat. The existence of an atypical histamine response, resistant to both H1- and H2-receptor antagonists is thus established in cat bronchus.

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Section: Discussionmentioning

confidence: 47%

Atypical (relaxant) response to histamine in cat bronchus

Chand

Eyre

1977

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“…Furthermore, some human studies have suggested that the bronchoprotection and bronchodilation involve distinct physiological mechanisms (55). In particular, the release of relaxant factors, such as prostaglandins or atrial natriuretic peptide, through stretchactivated neural or hormonal pathways may be the mechanism in which DI can protect against future bronchoconstriction (5,52,59). Functional changes to the ASM due to chronic inflammation could potentially inhibit these stretch-induced mechanisms in asthma (18).…”

Section: Discussionmentioning

confidence: 99%

Can tidal breathing with deep inspirations of intact airways create sustained bronchoprotection or bronchodilation?

Harvey

Parameswaran

Lutchen

2013

Journal of Applied Physiology

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Harvey BC, Parameswaran H, Lutchen KR. Can tidal breathing with deep inspirations of intact airways create sustained bronchoprotection or bronchodilation?. J Appl Physiol 115: 436 -445, 2013. First published May 30, 2013 doi:10.1152/japplphysiol.00009.2013.-Fluctuating forces imposed on the airway smooth muscle due to breathing are believed to regulate hyperresponsiveness in vivo. However, recent animal and human isolated airway studies have shown that typical breathing-sized transmural pressure (Ptm) oscillations around a fixed mean are ineffective at mitigating airway constriction. To help understand this discrepancy, we hypothesized that Ptm oscillations capable of producing the same degree of bronchodilation as observed in airway smooth muscle strip studies requires imposition of strains larger than those expected to occur in vivo. First, we applied increasingly larger amplitude Ptm oscillations to a statically constricted airway from a Ptm simulating normal functional residual capacity of 5 cmH2O. Tidal-like oscillations (5-10 cmH2O) imposed 4.9 Ϯ 2.0% strain and resulted in 11.6 Ϯ 4.8% recovery, while Ptm oscillations simulating a deep inspiration at every breath (5-30 cmH2O) achieved 62.9 Ϯ 12.1% recovery. These same Ptm oscillations were then applied starting from a Ptm ϭ 1 cmH2O, resulting in approximately double the strain for each oscillation amplitude. When extreme strains were imposed, we observed full recovery. On combining the two data sets, we found a linear relationship between strain and resultant recovery. Finally, we compared the impact of Ptm oscillations before and after constriction to Ptm oscillations applied only after constriction and found that both loading conditions had a similar effect on narrowing. We conclude that, while sufficiently large strains applied to the airway wall are capable of producing substantial bronchodilation, the Ptm oscillations necessary to achieve those strains are not expected to occur in vivo.airway smooth muscle; intact airways; bronchodilation; bronchoprotection; asthma WHEN PERIODIC LENGTH OSCILLATIONS mimicking tidal breathing and deep inspirations (DIs) are applied to airway smooth muscle (ASM) during or after excitation, the increase in ASM force is less than would otherwise have occurred, if the excitatory stimulus were applied while the ASM was static (13,21,61). This observation led to the notion that periodic length fluctuations perturb the binding of myosin to actin (14,33,38,48), or cause remodeling of the contractile apparatus (19,30,50), thereby limiting the resultant tension that the ASM can generate. With regard to asthma, the isolated ASM studies motivated the conjecture that the mechanism behind the beneficial effect of DIs in preventing airway hyperresponsiveness (AHR) is intricately tied to stretching of the ASM during breathing (13,17,29,48). By extrapolation, these ASM strip level studies led to the hypothesis that, in asthmatic subjects, conditions such as wall remodeling or the presence of a milieu of inflammatory mediators could all...

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“…It relaxes isolated tracheal or bronchial segments and prevents or attenuates their contraction by a variety of constrictors [3]. It stimulates water and ion transport in ca nine tracheal epithelium [4] and also the secretion of sulfated macromoleculcs by tracheal explants from ferrets [5].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Vasoactive Intestinal Peptide on Superoxide Anion Formation by N-Formyl-Methionyl-Leucyl-Phenylalanine-Activated Inflammatory Cells in vitro

Kurosawa¹,

Ishizuka²

1993

Int Arch Allergy Immunol

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Effects of vasoactive intestinal peptide (VIP) on superoxide anion (O^––₂) formation by N-formyl-methionyl-leucyl-phenylalanine (fMLP)-activated inflammatory cells from healthy volunteers were investigated using 2-methyl-6-[p-methoxyphenyl]-3,7-dihydroimidazo [1,2-a]pyrazin-3-one (MCLA) as a chemiluminescence probe. VIP inhibited the maximal light intensity of MCLA-dependent luminescence in a dose-dependent manner by the activated peripheral blood neutrophils, mononuclear cells and also by the human monoblast cell line U937, the capacity of which for O^––₂ formation was induced by pretreatment with interferon-γ. 3 × 10^––6M VIP also inhibited O^––₂ formation by the activated peripheral blood eosinophils and alveolar macrophages obtained by bronchoalveolar lavage.

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Humoral Control of Airways*

Cited by 61 publications

References 20 publications

Atypical (relaxant) response to histamine in cat bronchus

Atypical (relaxant) response to histamine in cat bronchus

Can tidal breathing with deep inspirations of intact airways create sustained bronchoprotection or bronchodilation?

Inhibitory Effects of Vasoactive Intestinal Peptide on Superoxide Anion Formation by N-Formyl-Methionyl-Leucyl-Phenylalanine-Activated Inflammatory Cells in vitro

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