Humoral and cell mediated immune responses to a pertussis containing vaccine in pregnant and nonpregnant women

Huygen, Kris; Caboré, Raïssa Nadège; Maertens, Kirsten; Damme, Pierre Van; Leuridan, Elke

doi:10.1016/j.vaccine.2015.06.108

Cited by 55 publications

(43 citation statements)

References 35 publications

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“…Pertussis vaccination during pregnancy offers an ideal strategy to protect the mother and the newborn against potentially life-threatening disease (42). Therefore, better understanding the nature of maternal immunity to vaccines is of interest not only for the knowledge of basic mechanisms but also in designing better vaccines and implementing vaccination strategies to protect the fetus, the mother, and the newborn.…”

Section: Discussionmentioning

confidence: 99%

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Protective Role of Passively Transferred Maternal Cytokines against Bordetella pertussis Infection in Newborn Piglets

et al. 2017

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Maternal vaccination represents a potential strategy to protect both the mother and the offspring against life-threatening infections. This protective role has mainly been associated with antibodies, but the role of cell-mediated immunity, in particular passively transferred cytokines, is not well understood. Here, using a pertussis model, we have demonstrated that immunization of pregnant sows with heat-inactivated bacteria leads to induction of a wide range of cytokines (e.g., tumor necrosis factor alpha [TNF-␣], gamma interferon [IFN-␥], interleukin-6 [IL-6], IL-8, and IL-12/IL-23p40) in addition to pertussis-specific antibodies. These cytokines can be detected in the sera and colostrum/milk of vaccinated sows and subsequently were detected at significant levels in the serum and bronchoalveolar lavage fluid of piglets born to vaccinated sows together with pertussis-specific antibodies. In contrast, active vaccination of newborn piglets with heat-inactivated bacteria induced high levels of specific IgG and IgA but no cytokines. Although the levels of antibodies in vaccinated piglets were comparable to those of passively transferred antibodies, no protection against Bordetella pertussis infection was observed. Thus, our results demonstrate that a combination of passively transferred cytokines and antibodies is crucial for disease protection. The presence of passively transferred cytokines/antibodies influences the cytokine secretion ability of splenocytes in the neonate, which provides novel evidence that maternal immunization can influence the newborn's cytokine milieu and may impact immune cell differentiation (e.g., Th1/Th2 phenotype). Therefore, these maternally derived cytokines may play an essential role both as mediators of early defense against infections and possibly as modulators of the immune repertoire of the offspring.

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Section: Discussionmentioning

confidence: 99%

“…Interestingly, that study indicated that vaccine-specific cellular response was less pronounced in pregnant women than in control women (42). In contrast, another study has reported robust cellular immune response to inactivated influenza vaccine during pregnancy (43).…”

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confidence: 93%

Protective Role of Passively Transferred Maternal Cytokines against Bordetella pertussis Infection in Newborn Piglets

et al. 2017

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“…Furthermore, boosting with Tdap vaccines during pregnancy, aiming to close the susceptibility gap of young infants for pertussis, may offer at the same time the needed protection for women and neonates against diphtheria and tetanus. 10,11 Disclosure of potential conflicts of interest No potential conflicts of interest were disclosed.…”

Section: Resultsmentioning

confidence: 99%

Development of human monoclonal antibodies to diphtheria toxin: A solution for the increasing lack of equine DAT for therapeutic use?

Huygen

2016

Virulence

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“…Fewer studies have examined the impact of pregnancy on the antibody response to pertussis immunization. Two studies reported similar antibody responses to pertussis immunization in pregnant and non-pregnant women [91,92]. However, one of the two studies reported lower T cell responses to pertussis antigens in pregnant as compared to non-pregnant women [92].…”

Section: Effect Of Pregnancy On Vaccine Responsesmentioning

confidence: 99%

Immunobiological aspects of vaccines in pregnancy: Maternal perspective

Chu

Marchant

2020

Maternal Immunization

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Humoral and cell mediated immune responses to a pertussis containing vaccine in pregnant and nonpregnant women

Cited by 55 publications

References 35 publications

Protective Role of Passively Transferred Maternal Cytokines against Bordetella pertussis Infection in Newborn Piglets

Protective Role of Passively Transferred Maternal Cytokines against Bordetella pertussis Infection in Newborn Piglets

Development of human monoclonal antibodies to diphtheria toxin: A solution for the increasing lack of equine DAT for therapeutic use?

Immunobiological aspects of vaccines in pregnancy: Maternal perspective

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