Humidification in paediatric anaesthesia

Brock‐Utne, John G.

doi:10.1046/j.1460-9592.2000.00448.x

Cited by 3 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, subjects who received humidification therapy during mechanical ventilation did not present with any significant changes to their epithelial cell structure. Previous studies 29,30 showed that, during general anesthesia, the delivery of cold, dry gas into the lower respiratory tract resulted in pulmonary surfactant changes, increased pulmonary surface tension, and alveolar collapse. Based on the data presented in this report, we recommend that patients receiving general anesthesia also receive humidification therapy.…”

Section: Discussionmentioning

confidence: 99%

“…without humidification. Four experimental groups (32 rabbits total, n ϭ 8/temperature) received mechanical ventilation under humidification at 30, 35, 40, and 45°C (30,35,40, and 45°C groups, respectively). The different temperatures correspond to the temperature at the Y-piece of the inspiratory port (T4).…”

Section: What This Paper Contributes To Our Knowledgementioning

confidence: 99%

See 1 more Smart Citation

Airway Humidification Reduces the Inflammatory Response During Mechanical Ventilation

et al. 2015

View full text Add to dashboard Cite

BACKGROUND: Currently, no clinical or animal studies have been performed to establish the relationship between airway humidification and mechanical ventilation-induced lung inflammatory responses. Therefore, an animal model was established to better define this relationship. METHODS: Rabbits (n ‫؍‬ 40) were randomly divided into 6 groups: control animals, sacrificed immediately after anesthesia (n ‫؍‬ 2); dry gas group animals, subjected to mechanical ventilation for 8 h without humidification (n ‫؍‬ 6); and experimental animals, subjected to mechanical ventilation for 8 h under humidification at 30, 35, 40, and 45°C, respectively (n ‫؍‬ 8). Inflammatory cytokines in the bronchi alveolar lavage fluid (BALF) were measured. The integrity of the airway cilia and the tracheal epithelium was examined by scanning and transmission electron microscopy, respectively. Peripheral blood white blood cell counts and the wet to dry ratio and lung pathology were determined. RESULTS: Dry gas group animals showed increased tumor necrosis factor alpha levels in BALF compared with control animals (P < .05). The tumor necrosis factor alpha and interleukin-8 levels in the BALF reached baseline levels when the humidification temperature was increased to 40°C. Scanning and transmission electron microscopy analysis revealed that cilia integrity was maintained in the 40°C groups. Peripheral white blood cell counts were not different among those groups. Compared with control animals, the wet to dry ratio was significantly elevated in the dry gas group (P < .05). Moreover, humidification at 40°C resulted in reduced pathologic injury compared with the other groups based on the histologic score. CONCLUSIONS: Pathology and reduced inflammation observed in animals treated at 40°C was similar to that observed in the control animals, suggesting that appropriate humidification reduced inflammatory responses elicited as a consequence of mechanical ventilation, in addition to reducing damage to the cilia and reducing water loss in the airway.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: What This Paper Contributes To Our Knowledgementioning

confidence: 99%