Humic Acid Enhances Wound Healing in the Rat Palate

Çalışır, Metin; Akpınar, Aysun; Talmaç, Ahmet Cemil; Alpan, Aysan Lektemür; Göze, Ömer Fahrettin

doi:10.1155/2018/1783513

Cited by 12 publications

(9 citation statements)

References 24 publications

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“…Hammad et al 44 reported that 0.2% chlorhexidine gel showed a very good effect in reducing the wound surface on days 7 and 14 compared to the group to which they applied allantoin. Similar to our study, Calisir et al 24 compared the concentrations of 0.09% saline, 0.05% chlorhexidine, and 80 mg/kg of humic acid, and they found on days 7 and 14 of the trial that the groups with chlorhexidine and humic acid were better at closing the wound surfaces than the groups that received saline. In the same study, it was also found that chlorhexidine and humic acid had similar levels of activity when compared among the groups.…”

Section: Discussionsupporting

confidence: 89%

“…Ji et al 23 conducted a study on rats, and showed that humic acid accelerates the healing of wounds on the surface of the skin. Calisir et al 24 reported that humic acid was effective in closing wounds on the palatal mucosa in rats. Although these results suggest that humic acids may be useful in wound healing in palatal mucosa, there is currently not enough evidence showing the effects of humic acid on wound healing in oral cavity.…”

Section: Introductionmentioning

confidence: 99%

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Lokal Hümik Uygulamasının Yara İyileşmesi Üzerine Etkisinin Değerlendirilmesi

DÖNMEZ¹,

Akpınar

Göze

2022

Cumhuriyet Dental Journal

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Objective:The purpose of the present study was to examine the effects of topical humic acid application on healing in oral mucosa wound in rats. Material and Methods:A total of 12-week-old 72 Wistar male rats weighing 280-300 gr were used in the study. The rats were randomly grouped in 4 groups as the Control Group (K) to which no applications were made, Chlorhexidine (0.12%) Group (CHX), 80 mg/kg Humic Acid Group (HA80), and 150 mg/kg Humic Acid Group (HA150). Mucosal defects of 5-mmdiameter were induced with punch in the palatal areas of the rats. These groups were further divided into 3 sub-groups to be sacrificed on days 7, 14 and 21. Epithelization, ulceration, polymorphic nuclear leukocytes (PNL), mononuclear cells (MNL), fibroblast and vascularization were examined in histopathologic evaluations. In addition, photos of the tissue samples were taken and transferred to the computer medium for histo-morphometric examinations.Results: As a result of the statistical analyses, no significant differences were detected among the groups in terms of epithelization degree, PNL and MNL cell infiltration on days 7, 14 and 21. The ulcerated areas were low in HA150 Group compared to the other groups, and there was a significant difference in this respect (p<0.05). Vascularization degrees were evaluated, the K Group and HA150 Group showed better results on day 7 (p<0.05). On days 14 and 21, no significant differences were detected among the groups (p>0.05).Wound area measurement scores were lower in HA150 Group compared to the other groups, and this result showed that the healing in HA150 Group was better (p<0.05). Conclusions:As a result of the present study, it was found that humic acid increased wound healing in oral cavity.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Lokal Hümik Uygulamasının Yara İyileşmesi Üzerine Etkisinin Değerlendirilmesi

DÖNMEZ¹,

Akpınar

Göze

2022

Cumhuriyet Dental Journal

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“…After 3 weeks of humic acid administration the found out statistically significant difference between the saline control and the chlorhexidine gluconate group at the end of three weeks.They observed reduced inflammation and the granulation tissue with constricted mucosal epithelial layer. [24] When the groups were evaluated together in terms of pathological examinations, there was a statistically significant improvement in edema, hemorrhage, PNL, MNL / microglia / macrophage evaluations (p <0.05). In the paraplegia evaluation with the modified Tarlov Scoring, there was a significant improvement in the HA group compared with the control group (p <0.001) (Table 1).…”

Section: Discussionmentioning

confidence: 92%

Effect of Humic Acid on Oxidative Stress and Neuroprotection in Traumatic Spinal Cord Injury: An Experimental Study

2021

Turk J Med Sci

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Objective: Traumatic spinal cord injury (TSCI) is an important health problem especially in developing countries with additional socio-economic loss. Humic acids (HA) usually have anti-oxidant, anti-inflammatory, blood-circulating and antiviral effects. We aimed to show effect of HA on neuroprotection in TSCI model. Methods: We performed TSCI model in Twenty-four Wistar-Albino rats in four groups. Control group underwent only laminectomy. Sham group underwent laminectomy followed by TSCI. Low dose HA (5mg/kg) and high dose HA (10mg/kg) groups underwent laminectomy and TSCI followed by peritoneal administration of HA.with the control group (p<0.05). There is a significant recovery in paraplegia level as we compared the HA groups with control groups (p<0.001). Conclusion:In this study, we showed the effects of HA in the early stages of TSCI on oxidative stress, histopathological changes and neurological improvement. It is thought to be a potential therapeutic agent in acute TSCI but needs to be further evaluated by showing proper effect on other neuroprotective pathways in larger series.

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“…HA has been previously demonstrated to enhance the WH process because of its antibacterial, antioxidant, immunomodulatory, and anti-inflammatory properties. [ 12 ]…”

Section: Introductionmentioning

confidence: 99%

“…The antioxidant activity of HA is due to its ability to bind to oxygen reactive. [ 12 ] The promotion function of Nrf2 transcriptions as well as its coding proteins in WH is due to their activities against oxidative stress. [ 13 ]…”

Section: Introductionmentioning

confidence: 99%

Evaluation of healing effects of poultice containing 0.5% fulvic acid on male white-male rats with skin ulcer

Samiee-Rad¹,

Sedighi²,

Taherkhani³

et al. 2022

J Cutan Aesthet Surg

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Background: Chronic and acute skin wounds are an important health concern because they are very frequent during human life and affect millions of people worldwide. Shortening the wound healing process reduces treatment costs and hospitalization. Therefore, researchers have been looking for new treatment approaches to shorten the wound healing process. Aims and Objectives: The aim of this study was to evaluate the wound healing properties of poultice containing 0.5% fulvic acid. Materials and Methods: In this experimental study, a full-thickness skin wound was created on the dorsal side of 24 male rats. The animals were then randomly assigned to control, sham, and experiment groups. The skin defects were daily bandaged by using sterile gauze dipped in normal saline, carboxymethylcellulose, and 0.5% fulvic acid for 21 days, respectively. The wound healing rate was evaluated grossly and histologically at various time intervals post injury. Both descriptive and statistical analysis methods were applied ( P < 0.05). Results: The wound healing percentage was significantly higher in the poultice treatment group at all time intervals ( P < 0.001). The wound was completely closed in this group compared with other groups at the end of week 4 post treatment. The mean numbers of inflammatory cells were statistically lower, and fibroblasts and vessels were higher in the poultice group than in the other groups at various time intervals post injury ( P < 0.001). Conclusion: Fulvic acid (0.5%) could be used as an effective therapeutic approach to improve the wound healing process because of its unique anti-inflammatory and neovascularization properties at the skin wound site.

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Humic Acid Enhances Wound Healing in the Rat Palate

Cited by 12 publications

References 24 publications

Lokal Hümik Uygulamasının Yara İyileşmesi Üzerine Etkisinin Değerlendirilmesi

Lokal Hümik Uygulamasının Yara İyileşmesi Üzerine Etkisinin Değerlendirilmesi

Effect of Humic Acid on Oxidative Stress and Neuroprotection in Traumatic Spinal Cord Injury: An Experimental Study

Evaluation of healing effects of poultice containing 0.5% fulvic acid on male white-male rats with skin ulcer

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