Humane Endpoints and Cancer Research

Liposomal glucocorticoids as tumor-targeted anti-angiogenic nanomedicine in B16 melanoma-bearing mice

“…In case of LCL-BUP, body weight loss was 5-10% during the entire treatment. These side effects noted did not exceed the humane endpoints in animal experiments for biomedical research [31].…”

Statutory Imposed Terms of Stress, Distress, Well-Being and Animal Welfare: Suggested Guidelines for Humane Endpoints in Animal Studies

“…The scientific endpoint is defined as "the criteria that will be used to indicate that the experimental objective has been reached" [39]. This endpoint relates to the data which must be gathered to achieve the objectives of an experiment.…”

Cooperation of CD4+ T cells and CD8+ T cells and release of IFN-γ are critical for antileukemia responses of recipient mice treated by microtransplantation

“…No early death was observed until the end-point of the experiments at +3 days, which was set according to international guidelines (16). Regarding weight, mental condition, appetite, activity, diarrhea, skin and hair, no significant differences were present among the groups.…”