Human visceral leishmaniasis in Bolivia: first proven autochthonous case from ‘Los Yungas’

Desjeux, Philippe; Aranda, Eugenia Candanosa; Aliaga, O.; Mollinedo, S.

doi:10.1016/0035-9203(83)90305-x

Cited by 15 publications

(10 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, another explanation for this result is that this genotype entered MS from Northeast Brazil, where a highly successful adaptation facilitated a clonal expansion. It would be interesting to evaluate the possibility of an influence from Eastern Bolivia, although in that country, the only endemic area that has been reported is Los Yungas, La Paz, which does not seem to be connected to the Brazilian foci [88], [89].…”

Section: Discussionmentioning

confidence: 99%

The Genetic Structure of Leishmania infantum Populations in Brazil and Its Possible Association with the Transmission Cycle of Visceral Leishmaniasis

et al. 2012

View full text Add to dashboard Cite

Leishmania infantum is the etiologic agent of visceral leishmaniasis (VL) in the Americas, Mediterranean basin and West and Central Asia. Although the geographic structure of L. infantum populations from the Old World have been described, few studies have addressed the population structure of this parasite in the Neotropical region. We employed 14 microsatellites to analyze the population structure of the L. infantum strains isolated from humans and dogs from most of the Brazilian states endemic for VL and from Paraguay. The results indicate a low genetic diversity, high inbreeding estimates and a depletion of heterozygotes, which together indicate a predominantly clonal breeding system, but signs of sexual events are also present. Three populations were identified from the clustering analysis, and they were well supported by F statistics inferences and partially corroborated by distance-based. POP1 (111 strains) was observed in all but one endemic area. POP2 (31 strains) is also well-dispersed, but it was the predominant population in Mato Grosso (MT). POP3 (31 strains) was less dispersed, and it was observed primarily in Mato Grosso do Sul (MS). Strains originated from an outbreak of canine VL in Southern Brazil were grouped in POP1 with those from Paraguay, which corroborates the hypothesis of dispersal from Northeastern Argentina and Paraguay. The distribution of VL in MS seems to follow the west-east construction of the Bolivia-Brazil pipeline from Corumbá municipality. This may have resulted in a strong association of POP3 and Lutzomyia cruzi, which is the main VL vector in Corumbá, and a dispersion of this population in this region that was shaped by human interference. This vector also occurs in MT and may influence the structure of POP2. This paper presents significant advances in the understanding of the population structure of L. infantum in Brazil and its association with eco-epidemiological aspects of VL.

show abstract

Section: Discussionmentioning

confidence: 99%

The Genetic Structure of Leishmania infantum Populations in Brazil and Its Possible Association with the Transmission Cycle of Visceral Leishmaniasis

et al. 2012

View full text Add to dashboard Cite

show abstract

“…host, Leishmania venezuelensis). Desjeux et al 1983: 851 (Bolivia). Ward et al 1983: 269 (crossbreeding, variants of longipalpis).…”

Section: Fig 30mentioning

confidence: 99%

Guide to the Identification and Geographic Distribution of Lutzomyia Sand Flies in Mexico, the West Indies, Central and South America (Diptera:Psychodidae)

Young¹,

Duran²

1994

695

863

View full text Add to dashboard Cite

“…To our knowledge, VL remains rare in Bolivia and is restricted to this unique focus in the Yungas region in the Beni department, where the first autochthonous case was diagnosed in 1984. 31 Unlike in many other endemic areas in Latin America, coinfection of Leishmania with HIV is not described in the literature; however, recently HIV infection was detected in an adult male with ML caused by L. (V.) braziliensis in Cochabamba (Parrado and others, unpublished data).…”

Section: Disease Distribution Notification and Incidencementioning

confidence: 99%

“…22 All parasite isolates that have been characterized to species have primarily been reported in the north, center, and east of the country (i.e., Departments of La Paz, Beni, Pando, Santa Cruz, and Cochabamba) ( Figure 1 ). [16][17][18][19][20][21][22][23][24][25][26][27][28][29] Leishmania (L.) infantum , the causative agent of VL, was isolated from or detected in patients, [31][32][33] dogs, 34,35 and the insect vector Lutzomyia longipalpis 36 in the Yungas region in the Department of La Paz. To our knowledge, VL remains rare in Bolivia and is restricted to this unique focus in the Yungas region in the Beni department, where the first autochthonous case was diagnosed in 1984.…”

Section: Disease Distribution Notification and Incidencementioning

confidence: 99%

Leishmaniases in Bolivia: Comprehensive Review and Current Status

García

Parrado²,

Rojas³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. The leishmaniases are protozoan, zoonotic diseases transmitted to human and other mammal hosts by the bite of phlebotomine sandflies. Bolivia has the highest incidence of cutaneous leishmaniasis (CL) in Latin America (LA), with 33 cases per 100,000 population reported in 2006. CL is endemic in seven of the country's nine administrative departments. Visceral leishmaniasis (VL) is comparatively rare and is restricted to one single focus. Most CL cases are caused by Leishmania ( Viannia ) braziliensis (85% cases); VL is caused by L. (L.) infantum. Seven sandfly species are incriminated as vectors and Leishmania infections have been detected in several non-human mammal hosts. Transmission is associated with forest-related activities, but recently, cases of autochthonous, urban transmission were reported. Because most cases are caused by L. (V.) braziliensis, Bolivia reports the greatest ratio (i.e., up to 20% of all cases) of mucosal leishmaniasis to localized CL cases in LA. Per national guidelines, both CL and VL cases are microscopically diagnosed and treated with pentavalent antimony.

show abstract

Human visceral leishmaniasis in Bolivia: first proven autochthonous case from ‘Los Yungas’

Cited by 15 publications

References 4 publications

The Genetic Structure of Leishmania infantum Populations in Brazil and Its Possible Association with the Transmission Cycle of Visceral Leishmaniasis

The Genetic Structure of Leishmania infantum Populations in Brazil and Its Possible Association with the Transmission Cycle of Visceral Leishmaniasis

Guide to the Identification and Geographic Distribution of Lutzomyia Sand Flies in Mexico, the West Indies, Central and South America (Diptera:Psychodidae)

Leishmaniases in Bolivia: Comprehensive Review and Current Status

Contact Info

Product

Resources

About