Human vascular progenitor cells derived from renal arteries are endothelial-like and assist in the repair of injured renal capillary networks

Pang, Paul; Abbott, Molly; Chang, Steven L.; Abdi, Malyun; Chauhan, Nikita; Mistri, Murti; Ghofrani, Joshua; Fucci, Quynh-Anh; Walker, Colleen C.; Leonardi, C.; Grady, Samuel; Halim, Arvin; Hoffman, Ryan J.; Lu, Tzongshi; Cao, Huixia; Tullius, Stefan G.; Malek, Sayeed K.; Kumar, S. Ashutosh; Steele, Graeme S.; Kibel, Adam S.; Freedman, Benjamin; Waikar, Sushrut S.; Siedlecki, Andrew

doi:10.1016/j.kint.2016.07.037

Cited by 36 publications

(50 citation statements)

References 46 publications

(49 reference statements)

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“…The main miRNAs involved in renal protection from IRI, type of secreting cell, and mechanisms of action are outlined in Table 3 (172)(173)(174)(175)(176)(177)(178)(179)(180)(181).…”

Section: Extracellular Vesicles As a Therapeutic Tool In Renal Transpmentioning

confidence: 99%

Extracellular Vesicles as Mediators of Cellular Crosstalk Between Immune System and Kidney Graft

et al. 2020

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Extracellular vesicles (EVs) are known immune-modulators exerting a critical role in kidney transplantation (KT). EV bioactive cargo includes graft antigens, costimulatory/inhibitory molecules, cytokines, growth factors, and functional microRNAs (miRNAs) that may modulate expression of recipient cell genes. As paracrine factors, neutrophil-and macrophage-derived EVs exert immunosuppressive and immune-stimulating effects on dendritic cells, respectively. Dendritic cell-derived EVs mediate alloantigen spreading and modulate antigen presentation to T lymphocytes. At systemic level, EVs exert pleiotropic effects on complement and coagulation. Depending on their biogenesis, they can amplify complement activation or shed complement inhibitors and prevent cell lysis. Likewise, endothelial-and platelet-derived EVs can exert procoagulant/prothrombotic effects and also promote endothelial survival and angiogenesis after ischemic injury. Kidney endothelial-and tubular-derived EVs play a key role in ischemia-reperfusion injury (IRI) and during the healing process; additionally, they can trigger rejection by inducing both alloimmune and autoimmune responses. Endothelial EVs have procoagulant/pro-inflammatory effects and can release sequestered self-antigens, generating a tissue-specific autoimmunity. Renal tubule-derived EVs shuttle pro-fibrotic mediators (TGF-β and miR-21) to interstitial fibroblasts and modulate neutrophil and T-lymphocyte influx. These processes can lead to peritubular capillary rarefaction and interstitial fibrosis-tubular atrophy. Different EVs, including those from mesenchymal stromal cells (MSCs), have been employed as a therapeutic tool in experimental models of rejection and IRI. These particles protect tubular and endothelial cells (by inhibition of apoptosis and inflammation-fibrogenesis or by inducing autophagy) and stimulate tissue regeneration (by triggering angiogenesis, cell proliferation, and migration). Finally, urinary and serum EVs represent potential biomarkers for delayed graft function (DGF) and acute rejection. In conclusion, EVs sustain an intricate crosstalk between graft tissue and innate/adaptive immune systems. EVs play a major role in allorecognition, IRI, autoimmunity, and alloimmunity and are promising as biomarkers and therapeutic tools in KT.

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“…The main miRNAs involved in renal protection from IRI, type of secreting cell, and mechanisms of action are outlined in Table 3 (172)(173)(174)(175)(176)(177)(178)(179)(180)(181).…”

Section: Extracellular Vesicles As a Therapeutic Tool In Renal Transpmentioning

confidence: 99%

Extracellular Vesicles as Mediators of Cellular Crosstalk Between Immune System and Kidney Graft

et al. 2020

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“…Recent study revealed that EVs‐derived bioactive molecules from different cell sources promote endothelial regeneration. Following treatment of injured endothelial cells with renal artery‐derived vascular progenitor cells (RAPC)‐derived exosomes, endothelial migration improved and stimulates a reparative phenotype . MPs derived from kidney‐derived mesenchymal stem cells (KMSCs) have been reported to ameliorate rarefaction of peritubular capillaries (PTC) in ischaemic kidneys via delivery of proangiogenic effectors.…”

Section: Evs‐mediated Intranephron Communicationmentioning

confidence: 99%

“…Following treatment of injured endothelial cells with renal artery-derived vascular progenitor cells (RAPC)-derived exosomes, endothelial migration improved and stimulates a reparative phenotype. 67 For example, urinary EV UMOD mRNA levels are progressively elevated from T2DM to DKD groups and correlate with eGFR and ACR levels. 71 We have recently isolated exosome released from podocyte in the urine, the vesicle structure was positive for the markers of both exosome and podocyte, CD9, AQP2 and nephrin.…”

mentioning

confidence: 99%

New insight into the role of extracellular vesicles in kidney disease

Feng

Tang

et al. 2018

J Cellular Molecular Medi

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Extracellular vesicles (EVs) are released to maintain cellular homeostasis as well as to mediate cell communication by spreading protective or injury signals to neighbour or remote cells. In kidney, increasing evidence support that EVs are signalling vesicles for different segments of tubules, intra‐glomerular, glomerular‐tubule and tubule‐interstitial communication. EVs released by kidney resident and infiltrating cells can be isolated from urine and were found to be promising biomarkers for kidney disease, reflecting deterioration of renal function and histological change. We have here summarized the recent progress about the functional role of EVs in kidney disease as well as challenges and future directions involved.

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“…In an animal model of renal ischemia/reperfusion (I/R) injury, Pang et al investigated renal artery-derived progenitor cells (RAPC) (defined as CD34+/CD105-cells) obtained from human renal arterial adventitia of radical nephrectomy specimens [73]. RAPC were found to have EPC–like characteristics.…”

Section: Epc Studies In Various Disease Modelsmentioning

confidence: 99%

Endothelial Progenitor Cells and Kidney Diseases

Özkök

Yildiz

2018

Kidney Blood Press Res

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Endothelial progenitor cells (EPC) are bone marrow derived or tissue-resident cells that play major roles in the maintenance of vascular integrity and repair of endothelial damage. Although EPCs may be capable of directly engrafting and regenerating the endothelium, the most important effects of EPCs seem to be depended on paracrine effects. In recent studies, specific microvesicles and mRNAs have been found to mediate the pro-angiogenic and regenerative effects of EPCs on endothelium. EPC counts have important prognostic implications in cardiovascular diseases (CVD). Uremia and inflammation are associated with lower EPC counts which probably contribute to increased CVD risks in patients with chronic kidney disease. Beneficial effects of the EPC therapies have been shown in studies performed on different models of CVD and kidney diseases such as acute and chronic kidney diseases and glomerulonephritis. However, lack of a clear definition and specific marker of EPCs is the most important problem causing difficulties in interpretation of the results of the studies investigating EPCs.

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Human vascular progenitor cells derived from renal arteries are endothelial-like and assist in the repair of injured renal capillary networks

Cited by 36 publications

References 46 publications

Extracellular Vesicles as Mediators of Cellular Crosstalk Between Immune System and Kidney Graft

Extracellular Vesicles as Mediators of Cellular Crosstalk Between Immune System and Kidney Graft

New insight into the role of extracellular vesicles in kidney disease

Endothelial Progenitor Cells and Kidney Diseases

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