Human validation of genes associated with a murine atherosclerotic phenotype

Applications and Limitations of Mouse Models for Understanding Human Atherosclerosis

“…Our conclusions differ from a recent study by Pasterkamp and colleagues in which the investigators concluded that, with the exception of lipoprotein metabolism, mouse studies are likely to be of very limited value in understanding the human disease (Pasterkamp et al, 2016). These investigators performed a comprehensive survey of mouse studies of candidate genes (in total 659) and focused on the overlap with human GWAS genes.…”

Reactive Oxygen Species Generation and Atherosclerosis

“…120 An inflamed endothelium recruits inflammatory cells, such as monocytes, via the expression of various mediators and chemokines. 121 This, in addition to the imbalance of ROS generation, leads to the disabling of monocytes into foam cells, which consume dead cells and lipids.…”

Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association

“…The similarities of mouse genes to those identified as promoting risk in human genome-wide association studies enhance the potential to extrapolate findings in mouse models to the human disease. 12,13 Also, mousebased models have been particularly useful for elucidating effects of individual genes on atherosclerosis, with subsequent confirmation of human relevance in many instances. Salient examples include the elucidation of genes regulating triglyceride-rich lipoprotein metabolism in mice and their impact on atherosclerosis, such as apoCIII 14 and apoAV.…”