Human UTY(KDM6C) Is a Male-specific Nϵ-Methyl Lysyl Demethylase

Walport, Louise J.; Hopkinson, Richard J.; Vollmar, M.; Madden, Sarah K.; Gileadi, C.; Oppermann, U.; Schofield, Christopher J.; Johansson, C.

doi:10.1074/jbc.m114.555052

Cited by 177 publications

(178 citation statements)

References 61 publications

(115 reference statements)

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“…While Kdm6a homozygous mutant females display severe and lethal developmental defects, males are only mildly affected (8)(9)(10)47). In light of emerging evidence of in vitro demethylase activity of KDM6C (11), the in vivo importance of KDM6A demethylase-dependent and -independent functions needs to be revisited.…”

Section: Discussionmentioning

confidence: 99%

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Histone Demethylase KDM6A Controls the Mammary Luminal Lineage through Enzyme-Independent Mechanisms

Yoo

Kang

et al. 2016

Molecular and Cellular Biology

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Section: Discussionmentioning

confidence: 99%

“…The Kdm6a gene is located on the X chromosome, and conclusions on enzyme-independent functions were primarily drawn from studies with male cells containing a homolog on the Y chromosome, Kdm6c, which has no apparent enzymatic activity. However, in vitro enzymatic activity of KDM6C has been described (11).…”

mentioning

confidence: 99%

Histone Demethylase KDM6A Controls the Mammary Luminal Lineage through Enzyme-Independent Mechanisms

Yoo

Kang

et al. 2016

Molecular and Cellular Biology

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“…In particular, UTX (KDM6A) is a H3K27 demethylase expressed from both X chromosomes 110 . In men, UTX has a homolog on the Y chromosome, called UTY (KDM6C), whose catalytic activity is very low or absent 111 . UTX has a tumor suppressing function and inactivating mutations in this gene are not compensated by UTY (Fig.…”

Section: A) X Chromosomementioning

confidence: 99%

Sexual dimorphism in cancer

et al. 2016

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The incidence of many cancer types is significantly higher in the male than female populations, with associated differences in survival. Occupational and/or behavioral factors are well known underlying determinants. However, cellular/molecular differences between the two sexes are also likely to be important. We are focusing here on the complex interplay that sexual hormones and sex chromosomes can have in intrinsic control of cancer initiating cell populations, tumor microenvironment and systemic determinants of cancer development like the immune system and metabolism. A better appreciation of these differences between the two sexes could be of substantial value for cancer prevention as well as treatment.3 Introduction (Epidemiology)

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“…A paralog of the X-chromosome-located KDM6A, termed UTY (also known as KDM6C), is located on the Y-chromosome. It is so far unknown whether UTY possesses in vivo demethylase activity Walport et al, 2014). KDM6A and KDM6B take part in the regulation of gene expression programs during development (Burgold et al, 2008(Burgold et al, , 2012Lee et al, 2012;Seenundun et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of KDM6 activity during murine ESC differentiation induces DNA damage

Hofstetter¹,

Kampka²,

Huppertz³

et al. 2016

Development

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Pluripotent embryonic stem cells (ESCs) are characterised by their capacity to self-renew indefinitely while maintaining the potential to differentiate into all cell types of an adult organism. Both the undifferentiated and differentiated states are defined by specific gene expression programs that are regulated at the chromatin level. Here, we have analysed the contribution of the H3K27me2-and H3K27me23-specific demethylases KDM6A and KDM6B to murine ESC differentiation by employing the GSK-J4 inhibitor, which is specific for KDM6 proteins, and by targeted gene knockout (KO) and knockdown. We observe that inhibition of the H3K27 demethylase activity induces DNA damage along with activation of the DNA damage response (DDR) and cell death in differentiating but not in undifferentiated ESCs. Laser microirradiation experiments revealed that the H3K27me3 mark, but not the KDM6B protein, colocalise with γH2AX-positive sites of DNA damage in differentiating ESCs. Lack of H3K27me3 attenuates the GSK-J4-induced DDR in differentiating Eed-KO ESCs. Collectively, our findings indicate that differentiating ESCs depend on KDM6 and that the H3K27me3 demethylase activity is crucially involved in DDR and survival of differentiating ESCs.

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Human UTY(KDM6C) Is a Male-specific Nϵ-Methyl Lysyl Demethylase

Cited by 177 publications

References 61 publications

Histone Demethylase KDM6A Controls the Mammary Luminal Lineage through Enzyme-Independent Mechanisms

Histone Demethylase KDM6A Controls the Mammary Luminal Lineage through Enzyme-Independent Mechanisms

Sexual dimorphism in cancer

Inhibition of KDM6 activity during murine ESC differentiation induces DNA damage

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