Human Urinary Kallidinogenase Improves Outcome of Stroke Patients by Shortening Mean Transit Time of Perfusion Magnetic Resonance Imaging

Li, Jingwei; Chen, Yan; Zhang, Xin; Zhang, Bing; Zhang, Meijuan; Xu, Yun

doi:10.1016/j.jstrokecerebrovasdis.2015.03.032

Cited by 26 publications

(26 citation statements)

References 20 publications

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“…After treatment with HUK, AIS patents' cerebral blood perfusion was significantly enhanced and mean transit time of perfusion was remarkably shorten, which are in accordance with increasing serum levels of VEGF and apelin ( 16 ). These two substances are all involved in vascular formation and maturation ( 17 , 18 ).…”

Section: Results From Clinical Trialssupporting

confidence: 52%

Therapeutic Values of Human Urinary Kallidinogenase on Cerebrovascular Diseases

Wei

Lyu²,

Yang

et al. 2018

Front. Neurol.

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The term “tissue kallikrein” is used to describe a group of serine proteases shared considerable sequence homology and colocalize in the same chromosomal locus 19q13. 2–q13.4. It has been widely discovered in various tissues and has been proved to be involved in kinds of pathophysiological processes, such as inhibiting oxidative stress, inflammation, apoptosis, fibrosis and promoting angiogenesis, and neurogenesis. Human Urinary Kallidinogenase (HUK) extracted from human urine is a member of tissue kallikrein which could convert kininogen to kinin and hence improve the plasma kinin level. Medical value of HUK has been widely investigated in China, especially on acute ischemic stroke. In this review, we will summarize the therapeutic values of Human Urinary Kallidinogenase on acute ischemic stroke and its potential mechanisms.

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Section: Results From Clinical Trialssupporting

confidence: 52%

Therapeutic Values of Human Urinary Kallidinogenase on Cerebrovascular Diseases

Wei

Lyu²,

Yang

et al. 2018

Front. Neurol.

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“…95 A small, open-label, controlled, prospective study implied that short-term application of human urinary kallidinogenase could upregulate vascular endothelial growth factor and apelin expression, shorten the MTT in MR perfusion, and improve the 3-month functional outcome, as compared with control, among patients with acute stroke. 96 According to a systematic review and meta-analysis of 24 trials with 2433 patients published in 2012, human urinary kallidinogenase injection reduced death or dependency in two trials (RR 0.69; 95% CI 0.55 to 0.86) and increased the rate of neurological improvement after treatment based on data from 20 trials (2117 patients) (RR 1.56; 95% CI 1.44 to 1.70) as compared with control, while the risks of non-fatal intracranial haemorrhage or death were not significantly different between those treated with human urinary kallidinogenase or controls. 97 …”

Section: Interventions To Enhance Cerebral Collateral Circulation In mentioning

confidence: 99%

Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017

et al. 2018

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Collateral circulation plays a vital role in sustaining blood flow to the ischaemic areas in acute, subacute or chronic phases after an ischaemic stroke or transient ischaemic attack. Good collateral circulation has shown protective effects towards a favourable functional outcome and a lower risk of recurrence in stroke attributed to different aetiologies or undergoing medical or endovascular treatment. Over the past decade, the importance of collateral circulation has attracted more attention and is becoming a hot spot for research. However, the diversity in imaging methods and criteria to evaluate collateral circulation has hindered comparisons of findings from different cohorts and further studies in exploring the clinical relevance of collateral circulation and possible methods to enhance collateral flow. The statement is aimed to update currently available evidence and provide evidence-based recommendations regarding grading methods for collateral circulation, its significance in patients with stroke and methods under investigation to improve collateral flow.

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“…Recent studies suggest that apelin-13 protects the neurovascular unit against ischemic injuries, which is dependent on an increase of VEGF-VEGF receptor 2 (VEGFR2) signaling, possibly by activating ERK and PI3K/AKT pathways (51). Moreover, the apelin/APJ system may work in coordination with VEGF to trigger vascular sprouting and CBF recovery from human urinary kallidinogenase (HUK)treated stroke patients in an ERK1/2-dependent manner (91,92). On the contrary, the expression of VEGF in cultured endothelial cells is partially suppressed by the apelin/APJ system inhibitor, suggesting that the apelin/APJ system may cooperate with VEGF to promote vascular growth in ischemic stroke (92).…”

Section: Promoting Angiogenesismentioning

confidence: 99%

The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target

et al. 2020

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The orphan receptor APJ and its endogenous ligand apelin, which are expressed in the brain, are the major components of the apelin/APJ system. Growing evidence shows that the apelin/APJ system plays a vital role in the pathophysiology of cerebral ischemic injury. Targeting the apelin/APJ system may have protective effects on cerebral ischemic injury. In this review, we sum up the latest research progress relating to the actions and therapeutic potential of the apelin/APJ system in ischemic stroke. An in-depth knowledge of the pathophysiological effects of the apelin/APJ system and the underlying mechanisms will help to develop novel therapeutic interventions for ischemic stroke.

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Human Urinary Kallidinogenase Improves Outcome of Stroke Patients by Shortening Mean Transit Time of Perfusion Magnetic Resonance Imaging

Cited by 26 publications

References 20 publications

Therapeutic Values of Human Urinary Kallidinogenase on Cerebrovascular Diseases

Therapeutic Values of Human Urinary Kallidinogenase on Cerebrovascular Diseases

Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017

The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target

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