Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying MicroRNA-181c-5p Promote BMP2-Induced Repair of Cartilage Injury through Inhibition of SMAD7 Expression

Zhang, Qiang; Cao, Le; Zou, Shanqi; Feng, Yuanling; Miao, Xudong; Huang, Lu; Wu, Yongping

doi:10.1155/2022/1157498

Cited by 15 publications

(10 citation statements)

References 32 publications

(34 reference statements)

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“…See Table 1 for information about miR‐181 targets in each differentiation lineage. References: [1] (H. Li et al, 2013), [2] (Ouyang et al, 2016), [3] (Z. Zhang et al, 2019), [4] (Knarr et al, 2019), [5] (Chen, Shi, et al, 2016), [6] (Chen, Ning, et al, 2016), [7] (Henao‐Mejia et al, 2013), [8] (C. Z. Chen et al, 2004), [9] (Gabler et al, 2015), [10] (P. Y. Lv, Xu et al, 2020), [11] (Barter et al, 2015), [12] (Vail et al, 2022), [13] (Melnik et al, 2021), [14] (Bakhshandeh, Soleimani, Paylakhi, et al, 2012), [15] (Q. Zhang et al, 2022), [16] (R. Su et al, 2015), [17] (X. Li, Zhang, et al, 2012), [18] (Naguibneva et al, 2006), [19] (Wei et al, 2016), [20] (P. Yuan et al, 2022), [21] (He et al, 2022), [22] (Y. Wang et al, 2020), [23] (Z. Zhao et al, 2019), [24] (Cichocki et al, 2011), [25] (Bhushan et al, 2013), [26] (N. Liu et al, 2020), [27] (Bakhshandeh, Soleimani, Hafizi, et al, 2012), [28] (Zheng, Liu, Tycksen, Nunley and McAlinden 2019), [29] (P. Qi et al, 2021), [30] (P. Y. Lv, Gao, et al, 2020), [31] (Ma et al, 2020), [32] (Y. Liu et al, 2021), [33] (Xie et al, 2018), [34] (B. Zhang et al, 2021), [35] (Shao et al, 2015), [36] (Shao et al, 2018), [37] (Fu et al, 2021), [38] (Han et al, 2020), [39] (Yu et al, 2021), [40] (T. Sun et al, 2019), [41] (G. Liu et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…The authors conclude that miR-181c enhanced cartilage repair, yet the ex vivo mouse model used in their study does not represent a cartilage injury model (Q. Zhang et al, 2022). It remains to be determined how miR-181c functions in the context of regulating cartilage repair or OA.…”

Section: Regulation Of Skeletal Tissue Homeostasismentioning

confidence: 96%

“…Interestingly, a recent study revealed that miR‐181c, via targeting SMAD7 , could enhance chondrogenesis as well as ectopic cartilage production in mice. The authors conclude that miR‐181c enhanced cartilage repair, yet the ex vivo mouse model used in their study does not represent a cartilage injury model (Q. Zhang et al, 2022). It remains to be determined how miR‐181c functions in the context of regulating cartilage repair or OA.…”

Section: Regulation Of Skeletal Tissue Homeostasismentioning

confidence: 99%

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The miR‐181 family: Wide‐ranging pathophysiological effects on cell fate and function

Bell-Hensley

Das

McAlinden

2023

Journal Cellular Physiology

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MicroRNAs (miRNAs) are epigenetic regulators that can target and inhibit translation of multiple mRNAs within a given cell type. As such, a number of different pathways and networks may be modulated as a result. In fact, miRNAs are known to regulate many cellular processes including differentiation, proliferation, inflammation, and metabolism. This review focuses on the miR‐181 family and provides information from the published literature on the role of miR‐181 homologs in regulating a range of activities in different cell types and tissues. Of note, we have not included details on miR‐181 expression and function in the context of cancer since this is a broad topic area requiring independent review. Instead, we have focused on describing the function and mechanism of miR‐181 family members on differentiation toward a number of cell lineages in various non‐neoplastic conditions (e.g., immune/hematopoietic cells, osteoblasts, osteoclasts, chondrocytes, adipocytes). We have also provided information on how modulation of miR‐181 homologs can have positive effects on disease states such as cardiac abnormalities, pulmonary arterial hypertension, thrombosis, osteoarthritis, and vascular inflammation. In this context, we have used some examples of FDA‐approved drugs that modulate miR‐181 expression. We conclude by discussing some common mechanisms by which miR‐181 homologs appear to regulate a number of different cellular processes and how targeting specific miR‐181 family members may lead to attractive therapeutic approaches to treat a number of human disease or repair conditions, including those associated with the aging process.

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Section: Discussionmentioning

confidence: 99%

Section: Regulation Of Skeletal Tissue Homeostasismentioning

confidence: 96%

Section: Regulation Of Skeletal Tissue Homeostasismentioning

confidence: 99%

See 1 more Smart Citation

The miR‐181 family: Wide‐ranging pathophysiological effects on cell fate and function

Bell-Hensley

Das

McAlinden

2023

Journal Cellular Physiology

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“…Treatment with exosomes carrying miR-140-3p was discovered to improve joint injury as well as reduce chondrocyte cell apoptosis in rats with rheumatoid arthritis (RA) through the targeting of SGK1 [101], while intra-articular injection with UCMSCs previously transfected with miR-140-5p could further induce the chondrogenetic and self-healing capacity of injured cartilage tissue in OA rats [102]. miR-181c-5p, delivered by hUCMSC-EVs, was shown to contribute to the repair of cartilage injuries by negatively regulating SMAD7 and promoting BMP2 expression, which in turn amplifies the proliferation, migration, and osteoblastic differentiation capacity of bone marrow stem cells [111].…”

Section: Regenerative Medicine (Wound Healing/bone Regeneration)mentioning

confidence: 99%

miRNA-Guided Regulation of Mesenchymal Stem Cells Derived from the Umbilical Cord: Paving the Way for Stem-Cell Based Regeneration and Therapy

Thomaidou

Goulielmaki

Tsintarakis

et al. 2023

IJMS

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The human body is an abundant source of multipotent cells primed with unique properties that can be exploited in a multitude of applications and interventions. Mesenchymal stem cells (MSCs) represent a heterogenous population of undifferentiated cells programmed to self-renew and, depending on their origin, differentiate into distinct lineages. Alongside their proven ability to transmigrate toward inflammation sites, the secretion of various factors that participate in tissue regeneration and their immunoregulatory function render MSCs attractive candidates for use in the cytotherapy of a wide spectrum of diseases and conditions, as well as in different aspects of regenerative medicine. In particular, MSCs that can be found in fetal, perinatal, or neonatal tissues possess additional capabilities, including predominant proliferation potential, increased responsiveness to environmental stimuli, and hypoimmunogenicity. Since microRNA (miRNA)-guided gene regulation governs multiple cellular functions, miRNAs are increasingly being studied in the context of driving the differentiation process of MSCs. In the present review, we explore the mechanisms of miRNA-directed differentiation of MSCs, with a special focus on umbilical cord-derived mesenchymal stem cells (UCMSCs), and we identify the most relevant miRNAs and miRNA sets and signatures. Overall, we discuss the potent exploitations of miRNA-driven multi-lineage differentiation and regulation of UCMSCs in regenerative and therapeutic protocols against a range of diseases and/or injuries that will achieve a meaningful clinical impact through maximizing treatment success rates, while lacking severe adverse events.

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“…hUCMSC-EVs can be internalized by BM-MSCs and promote the proliferation, migration, and chondrogenic differentiation potential of BM-MSCs. Furthermore, miR-181c-5p could target and repress SMAD7 expression to promote bone morphogenetic protein 2- (BMP2-) -induced proliferation, migration, and chondrogenic potential in BM-MSCs ( Zhang et al, 2022b ).…”

Section: Evs Of Human Umbilical Cord Mscs For Oa Therapymentioning

confidence: 99%

Therapeutic effects of different intervention forms of human umbilical cord mesenchymal stem cells in the treatment of osteoarthritis

Zhang

Zhuang

Ren

et al. 2023

Front. Cell Dev. Biol.

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Osteoarthritis (OA) is a common and disabling disease. For advanced OA, surgical treatment is still the main treatment. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are self-regenerative pluripotent cells, that coordinate cartilage regeneration by secreting various trophic factors, which adjust the injured tissue environment. hUC-MSCs secret extracellular vesicles and participates in OA treatment by transmitting bioactive molecules related to migration, proliferation, apoptosis, inflammatory reaction, extracellular matrix synthesis and cartilage repair. In addition, the combination of multiple substances represented by cartilage matrix and hUC-MSCs also have a significant synergistic effect on OA treatment. Because hUC-MSCs have shown considerable promise in cartilage repair, some scholars have proposed transplanting mesenchymal stem cells into damaged cartilage to delay OA progression. This article reviews the application of hUC-MSCs as a treatment for OA. With the continuous development of routine clinical applications, more reliable intervention modalities for hUC-MSCs in OA treatment will be discovered for the time to come.

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Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying MicroRNA-181c-5p Promote BMP2-Induced Repair of Cartilage Injury through Inhibition of SMAD7 Expression

Cited by 15 publications

References 32 publications

The miR‐181 family: Wide‐ranging pathophysiological effects on cell fate and function

The miR‐181 family: Wide‐ranging pathophysiological effects on cell fate and function

miRNA-Guided Regulation of Mesenchymal Stem Cells Derived from the Umbilical Cord: Paving the Way for Stem-Cell Based Regeneration and Therapy

Therapeutic effects of different intervention forms of human umbilical cord mesenchymal stem cells in the treatment of osteoarthritis

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