Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-451a represses epithelial–mesenchymal transition of hepatocellular carcinoma cells by inhibiting ADAM10

Xu, Yunxiuxiu; Lai, Yu; Cao, Lixue; Li, Yanshan; Chen, Guangcheng; Chen, Liang; Weng, Huinan; Chen, Tao; Wang, Lingyun; Ye, Yibiao

doi:10.1080/15476286.2020.1851540

Cited by 51 publications

(30 citation statements)

References 50 publications

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“…The molecule miR-451a has been studied in many types of cancer such as stomach cancer, hepatocellular carcinoma, bladder cancer, colorectal cancer, and basal cell carcinoma. Several studies have suggested that a low expression level of miR-451a positively correlates with the metastatic ability and invasiveness of cancer cells [ 23 , 24 , 25 , 26 , 27 ]. Some studies suggest that miR-451a can be used as a biological marker to predict the risk of recurrence [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

A two-microRNA signature predicts the progression of male thyroid cancer

et al. 2021

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In various cancers, microRNAs (miRNAs) are abnormally expressed, including thyroid cancer (TC). In recent years, the incidence of TC has increased annually around the world. Compared with female patients, male TC patients are more likely to have a postoperative recurrence and lymph node metastasis, and hence need second treatments. However, the molecular biological processes underlying this phenomenon are not understood. Therefore, we collected data on miRNA expression and clinical information of male TC patients from The Cancer Genome Atlas (TCGA) database. Differentially expressed miRNAs were identified between male TC tissues and matched normal tissues. The Kaplan–Meier method, univariate and multivariate Cox regressions, and receiver operating characteristic curve analyses were performed to assess the association between miRNAs and the disease-free survival of male TC patients. Gene Ontology (GO) and the Kyoto Encyclopaedia of Gene and Genome (KEGG) enrichment analyses were then used to explore the function of miRNA target genes. Furthermore, we evaluated the ability of the miRNA biomarker to predict survival in female TC patients. As a result, a total of 118 differentially expressed miRNAs were identified, including 25 upregulated and 93 downregulated miRNAs. Among them, miR-451a and miR-16-1-3p were confirmed to be independent prognostic factors for the disease-free survival rate. The target genes of miR-451a and miR-16-1-3p were identified, and functional analysis showed that these genes were enriched in 25 Go and KEGG accessions, including cell signal transduction, motor adhesion, phagocytosis, regulation of transcription, cell proliferation, angiogenesis, etc. Neither miR-451a and miR-16-1-3p, nor a prediction model based on both miRNAs effectively predicted survival in female TC patients. In conclusion, both miR-451a and miR-16-1-3p may play important roles in the processes of male TC. The two-miRNA signature involving miR-1258 and miR-193a may serve as a novel prognostic biomarker for male TC patients.

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Section: Discussionmentioning

confidence: 99%

A two-microRNA signature predicts the progression of male thyroid cancer

et al. 2021

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“…Exosomal miR-24-3p produced after SMMC-7721 cells treated with transforming growth factor β (TGF-β) undergo EMT can promote the migration and invasion of not treated SMC-7721 cells [63]. Besides, exosomal miRNA-451a derived from HUCMSCs can inhibit ADAM10 to decrease EMT in HCC [64]. At the same time, the exosomes derived from HCC cells can also mediate EMT through TGF-β/Smad and MAPK/ERK signaling pathways [65,66].…”

Section: Exosomal Mirna Regulates the Emt Processionmentioning

confidence: 99%

Role of Exosomes in Immune Microenvironment of Hepatocellular Carcinoma

Chen

Chi

Zhao

et al. 2022

Journal of Oncology

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Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Since most patients with HCC are diagnosed at the intermediate or advanced stage and because HCC has a high incidence of metastasis and recurrence, it is one of the leading causes of cancer death. Exosomes are a subtype of extracellular vesicles and are typically 30–150 nm in diameter. Originating from endosomes, they can be secreted by almost all living cells. They are widely present in various body fluids and serve as an important medium for the interactions between cells. A series of studies have revealed that exosomes-mediated intercellular transfer of proteins, nucleic acids, and metabolites plays a crucial role in the initiation and progression of HCC, hypoxia and angiogenesis, chemotherapy sensitivity, and cell death mode and regulates the immune microenvironment. In this paper, we reviewed the recent researches on the multiple roles of tumor-associated exosomes in the progression of HCC. We laid particular focus on those researches that reveal how exosomes regulate the tumor immune microenvironment (TIME) and how exosomal cargos affect the progression of HCC. Besides, we emphasize some prospective directions to achieve a more accurate and complete analysis of the HCC immune microenvironment.

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“…Additional studies demonstrated that over-expression of these ADAMs promoted proliferation of HCC cells and was predictive of poor survival outcomes. In parallel, miRNA-dependent down-regulation of ADAM9 [ 38 , 39 , 40 ], ADAM10 [ 41 , 42 , 43 , 44 , 45 , 46 ] and ADAM17 [ 47 , 48 , 49 , 50 ] was associated with reduced tumor progression, inhibition of cell proliferation and invasion and chemotherapy sensitization of HCC cells. The liver-specific miR-122 that targets both ADAM10 and ADAM17 is decreased in patient with HCC and was recently proposed as a biomarker for hepatocellular carcinoma related to hepatitis C virus infection [ 51 ].…”

Section: Adamalysins In Hepatocellular Carcinomamentioning

confidence: 99%

ADAM and ADAMTS Proteins, New Players in the Regulation of Hepatocellular Carcinoma Microenvironment

Théret

Bouezzedine

Azar

et al. 2021

Cancers

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The tumor microenvironment plays a major role in tumor growth, invasion and resistance to chemotherapy, however understanding how all actors from microenvironment interact together remains a complex issue. The tumor microenvironment is classically represented as three closely connected components including the stromal cells such as immune cells, fibroblasts, adipocytes and endothelial cells, the extracellular matrix (ECM) and the cytokine/growth factors. Within this space, proteins of the adamalysin family (ADAM for a disintegrin and metalloproteinase; ADAMTS for ADAM with thrombospondin motifs; ADAMTSL for ADAMTS-like) play critical roles by modulating cell–cell and cell–ECM communication. During last decade, the implication of adamalysins in the development of hepatocellular carcinoma (HCC) has been supported by numerous studies however the functional characterization of most of them remain unsettled. In the present review we propose both an overview of the literature and a meta-analysis of adamalysins expression in HCC using data generated by The Cancer Genome Atlas (TCGA) Research Network.

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Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-451a represses epithelial–mesenchymal transition of hepatocellular carcinoma cells by inhibiting ADAM10

Cited by 51 publications

References 50 publications

A two-microRNA signature predicts the progression of male thyroid cancer

A two-microRNA signature predicts the progression of male thyroid cancer

Role of Exosomes in Immune Microenvironment of Hepatocellular Carcinoma

ADAM and ADAMTS Proteins, New Players in the Regulation of Hepatocellular Carcinoma Microenvironment

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