Human Umbilical Cord Blood Stem Cells Rescue Ischemic Tissues

Park, Dong Hyuk; Lee, Jeong‐Hyun; Eve, David J.; Borlongan, Cesario V.; Sanberg, Paul R.; Chung, Yong-Gu; Cho, Tai-Hyoung

doi:10.5772/27879

Cited by 2 publications

(2 citation statements)

References 128 publications

(121 reference statements)

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“…40 Some studies suggest that the cells induce neovascularization in the necrotic area, [37][38][39] modulate the inflammatory reaction induced by ischemic cascades 41 and secrete growth factors 42,43 in animal models of IC.…”

Section: Discussionmentioning

confidence: 99%

Direct intracardiac injection of umbilical cord-derived stromal cells and umbilical cord blood-derived endothelial cells for the treatment of ischemic cardiomyopathy

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et al. 2015

Exp Biol Med (Maywood)

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The development of new therapeutic strategies is necessary to reduce the worldwide social and economic impact of cardiovascular disease, which produces high rates of morbidity and mortality. A therapeutic option that has emerged in the last decade is cell therapy. The aim of this study was to compare the effect of transplanting human umbilical cord-derived stromal cells (UCSCs), human umbilical cord blood-derived endothelial cells (UCBECs) or a combination of these two cell types for the treatment of ischemic cardiomyopathy (IC) in a Wistar rat model. IC was induced by left coronary artery ligation, and baseline echocardiography was performed seven days later. Animals with a left ventricular ejection fraction (LVEF) of 40% were selected for the study. On the ninth day after IC was induced, the animals were randomized into the following experimental groups: UCSCs, UCBECs, UCSCs plus UCBECs, or vehicle (control). Thirty days after treatment, an echocardiographic analysis was performed, followed by euthanasia. The animals in all of the cell therapy groups, regardless of the cell type transplanted, had less collagen deposition in their heart tissue and demonstrated a significant improvement in myocardial function after IC. Furthermore, there was a trend of increasing numbers of blood vessels in the infarcted area. The median value of LVEF increased by 7.19% to 11.77%, whereas the control group decreased by 0.24%. These results suggest that UCSCs and UCBECs are promising cells for cellular cardiomyoplasty and can be an effective therapy for improving cardiac function following IC.

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Section: Discussionmentioning

confidence: 99%

Direct intracardiac injection of umbilical cord-derived stromal cells and umbilical cord blood-derived endothelial cells for the treatment of ischemic cardiomyopathy

Suss

Capriglione

Barchiki

et al. 2015

Exp Biol Med (Maywood)

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show abstract

“…When compared with other MSCs from various sources, hUB-MSCs could be considered as a fascinating source for use in stem cell therapy [4,5]. Their extensive amplification capacity and low alloreactivity allow for the development of allogeneic "off-the-shelf" cell products, and they are increasingly cryopreserved at the time of birth for possible future autologous use [6].…”

Section: Introductionmentioning

confidence: 99%