Human Umbilical Cord Blood Mesenchymal Stem Cell Conditioned Medium (hMSC-CM) Improves Antioxidant Status in Carbon Tetrachloride-Induced Oxidative Damage in Rat

Bahmani, Mahdi; Ziamajidi, Nasrin; Hashemnia, Mohammad; Abbasalipourkabir, Roghayeh; Salehzadeh, Aref

doi:10.1007/s40995-020-00944-x

Cited by 7 publications

(8 citation statements)

References 40 publications

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“…Available evidence suggests that curcumin which is extracted as major lipophilic polyphenol from turmeric 7 , 8 exhibits antioxidant potential 27 and upregulates the expression of antioxidant enzymes of cellular defense system. 9 , 10 Similarly, antioxidant, anti-inflammatory, and anti-apoptotic properties have also been reported for metformin in some experimental conditions. 28 , 29 Thus, based on the antioxidant effects of curcumin and metformin, we hypothesized that these compounds may inhibit oxidative stress-induced apoptosis in heart tissue of diabetic rats.…”

Section: Discussionmentioning

confidence: 78%

“…in addition to the molecular structure-associated antioxidant nature of the curcumin, this compound increases the expression of antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) through upregulation of nuclear factor erythroid 2–related factor 2 (Nrf-2). 9 , 10 Available evidence also suggests that metformin has antioxidant, anti-inflammatory, and anti-apoptotic effects and might be therapeutically beneficial in improving diseases with inflammatory, apoptotic, and oxidative stress basis in their pathogenesis. 11…”

Section: Introductionmentioning

confidence: 99%

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Effects of curcumin and metformin on oxidative stress and apoptosis in heart tissue of type 1 diabetic rats

Naghdi

Goodarzi

Karimi

et al. 2022

J Cardiovasc Thorac Res

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Introduction: Hyperglycemia enhances oxidative stress and apoptosis and induces damages in heart tissue. Based on antioxidant properties of curcumin and metformin, we hypothesized that these agents may exhibit cardioprotective effects by attenuating oxidative stress and modulating expression of the genes involved in apoptosis in type-1 diabetes. Methods: Thirty-six male rats were randomly divided into six groups; (N): control; (D): streptozotocin-induced diabetic rats; (D+Cur50) and (D+Cur150): diabetic rats treated with 50 and 150 milligram of curcumin per kilogram of body weight (mg/kg.bw), respectively; (D+Met300) and (D+Met500): diabetic rats received 300 and 500 mg/kg.bw of metformin, respectively. Heart tissues were dissected and gene expression levels of Bax, Bcl-2, and caspase-3 were analyzed. Total anti-oxidant capacity (TAC), total oxidant status (TOS), and malondialdehyde (MDA) level, and activities of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured. Results: Enhancement in TOS, OSI, and MDA levels as well as increased in the activity of CAT and reduction in SOD and GPx activities were observed in diabetic group (D) compared with control rats. Treatment of diabetic animals with either curcumin or metformin normalized TOS, OSI, and MDA levels and restored CAT, SOD, and GPx activities. Diabetes caused extensive damages in heart tissue of rats (group D) and increased expression of caspase-3 and Bax genes and enhanced ratio of Bax/Bcl-2 expression compared with controls. Treatment with curcumin or metformin mitigated histopathological changes and dampened apoptosis by normalizing Bax and caspase-3 expression. Conclusion: Curcumin and metformin modulated diabetes-induced cardiac damage probably by reducing oxidative stress.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Effects of curcumin and metformin on oxidative stress and apoptosis in heart tissue of type 1 diabetic rats

Naghdi

Goodarzi

Karimi

et al. 2022

J Cardiovasc Thorac Res

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“…Intravenous Injection. Bahmani et al reported that intravenous injection of UMSC-CM (umbilical mesenchymal stem cells-condition media) could significantly improve liver fibrosis in male rats [38,39]. Tail vein injection of SCderived hepatocytes or SC-derived extracellular vesicles to animal with liver injuries had attenuated collagen deposition, liver fibrosis, and extracellular matrix alteration, it had decreased AST, ALT, increased serum ALB concentration, produced CK-18, enhanced liver regeneration and repair, and prolonged recipient survival [9,[40][41][42].…”

Section: In Vivo Results and Animalmentioning

confidence: 99%

The Efficiency of Stem Cells (SCs) Differentiation into Functional Hepatocytes for Treating Liver Disorders: A Systematic Review

Nemati

Ebrahimi

Abolhassani

et al. 2023

BioMed Research International

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Stem cells provided new opportunity to treat various diseases, including liver disorders. Stem cells are unspecialized cells, stimulating influential research interest be indebted to their multipotent self-renewal capacity and differentiation characteristics into several specialized cell types. Many factors contribute to their differentiation into different cell types such as insulin producing cells, osteoblast, and hepatocytes. Accordingly, wide range methods and materials have been used to transform stem cells into hepatocytes, but effectiveness of differentiation is different and depends on several factors such as cell-to-cell adhesion, cell-to-cell contact, and cell biological change. Search was done in PubMed, Scopus, and WOS to evaluate results of studies about stem cells differentiation for higher efficacy. Among more than 28000 papers, 51 studies were considered eligible for more evaluations. Results indicated that most studies were performed on mesenchymal stem cells compared with other types. Acute liver failure was the most investigated liver disorder, and tissue engineering was the most investigated differentiation methods. Also, functional parameters were the most evaluated parameters in assessing differentiation efficacy. We summarize recent advances in increasing efficiency of stem cells differentiation using varied materials, since promising results of this review, further studies are needed to assess efficiency and safety of these cells transplantation in some liver disease treatment.

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“…Finally, the slides were cleared with xylene solution, and a thin glass lamel was fixed on each slide. [ 22 ] The stained slides were evaluated by a pathologist to determine the severity of tissue damage in a blinded manner.…”

Section: Methodsmentioning

confidence: 99%

β‐lapachone protects against doxorubicin‐induced hepatotoxicity through modulation of NAD⁺/SIRT‐1/FXR/p‐AMPK/NF‐kB and Nrf2 signaling axis

Kalantary‐Charvadeh,

Nazari Soltan Ahmad,

Aslani

et al. 2023

J Biochem & Molecular Tox

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Doxorubicin (DOX) is a widely used antineoplastic drug, but its clinical use is limited by significant toxicities, such as hepatotoxicity. In this study, we evaluated the effects of β‐lapachone (β‐LAP), a natural quinone‐containing compound, in a mouse model of DOX‐induced hepatotoxicity. β‐LAP was orally administered at 1.25, 2.5, and 5 mg/kg for 4 days, and a single dose of DOX (20 mg/kg) was injected intraperitoneally on the second day. Histopathological changes, liver function markers, antioxidant and inflammatory markers were assessed. β‐LAP ameliorated liver injury and liver function markers evoked by DOX. β‐LAP also downregulated the mRNA expression of nuclear factor‐kB‐corresponding genes including interleukin‐6, interleukin‐1β, and tumor necrosis factor‐α. Moreover, β‐LAP increased the nuclear factor erythroid 2‐related factor 2 target genes heme oxygenase‐1 and NAD(P)H: quinone oxidoreductase 1, along with antioxidant enzymes including reduced glutathione, catalase, and superoxide dismutase with simultaneous reduction in the lipid peroxidation product malondialdehyde. Meanwhile, it recovered NAD+/NADH ratios and subsequently elevated the protein levels of sirtuin‐1 (SIRT‐1), farnesoid X receptor (FXR), and phosphorylated AMP‐activated protein kinase (p‐AMPK). Collectively, these findings suggest a protective role of β‐LAP against DOX‐induced hepatotoxicity by partly regulating the NAD+/SIRT‐1/FXR/p‐AMPK axis.

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Human Umbilical Cord Blood Mesenchymal Stem Cell Conditioned Medium (hMSC-CM) Improves Antioxidant Status in Carbon Tetrachloride-Induced Oxidative Damage in Rat

Cited by 7 publications

References 40 publications

Effects of curcumin and metformin on oxidative stress and apoptosis in heart tissue of type 1 diabetic rats

Effects of curcumin and metformin on oxidative stress and apoptosis in heart tissue of type 1 diabetic rats

The Efficiency of Stem Cells (SCs) Differentiation into Functional Hepatocytes for Treating Liver Disorders: A Systematic Review

β‐lapachone protects against doxorubicin‐induced hepatotoxicity through modulation of NAD⁺/SIRT‐1/FXR/p‐AMPK/NF‐kB and Nrf2 signaling axis

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Human Umbilical Cord Blood Mesenchymal Stem Cell Conditioned Medium (hMSC-CM) Improves Antioxidant Status in Carbon Tetrachloride-Induced Oxidative Damage in Rat

Cited by 7 publications

References 40 publications

Effects of curcumin and metformin on oxidative stress and apoptosis in heart tissue of type 1 diabetic rats

Effects of curcumin and metformin on oxidative stress and apoptosis in heart tissue of type 1 diabetic rats

The Efficiency of Stem Cells (SCs) Differentiation into Functional Hepatocytes for Treating Liver Disorders: A Systematic Review

β‐lapachone protects against doxorubicin‐induced hepatotoxicity through modulation of NAD+/SIRT‐1/FXR/p‐AMPK/NF‐kB and Nrf2 signaling axis

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Resources

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β‐lapachone protects against doxorubicin‐induced hepatotoxicity through modulation of NAD⁺/SIRT‐1/FXR/p‐AMPK/NF‐kB and Nrf2 signaling axis