Human umbilical cord blood effect on sod mice (amyotrophic lateral sclerosis)

Ende, Norman; Weinstein, Fran; Chen, Ruifeng; Ende, Milton

doi:10.1016/s0024-3205(00)00602-0

Cited by 125 publications

(73 citation statements)

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“…Apart from hematological disorders CNS diseases represent especially daunting challenges for cell-based strategies of repair. Studies by a number of groups support the idea that infusion of cells obtained from human cord blood lessen neural damage resulting from stroke, neurodegenerative diseases and spinal cord injury Ende et al, 2000;Chen et al, 2006).…”

Section: The Cord Blood Challenge For Brain Repairmentioning

confidence: 99%

“…It has been shown that infusion of HUCB cells delayed the progression of amyotrophic lateral sclerosis (ALS) and increased lifespan of the diseased, transgenic mice (Ende et al, 2000;Garbuzova-Davies et al, 2003). Systemic delivery of HUCB cells has an ability to prevent circulatory shock and resulting brain damage in the heatstroke animal model .…”

Section: The Cord Blood Challenge For Brain Repairmentioning

confidence: 99%

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A novel, neural potential of non-hematopoietic human umbilical cord blood stem cells

Domanska-Janik¹,

Bużañska²,

Łukomska³

2008

Int. J. Dev. Biol.

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From the time of discovery that among the cord blood mononuclear cell population there are cells capable of changing their fate towards the neural lineage and producing functional neurons and macroglial cells, our attempts have been focused on the understanding of the underlying mechanism of this transition. We have deciphered the first steps of neural stem/ progenitor gene induction in aggregating culture of cord blood mononuclear cells, their rapid phenotypic conversion under the influence of neuromorphogenic signals due to mitogen activation and their ability to expand and develop a prototypic, long-living line with neural stem cell properties. Evidence has accumulated that human umbilical cord-derived and neurally committed cells, due to their capacity for self-renewal, multilineage differentiation, plasticity and ability for long-lasting growth in vitro, provide unique material for the cell therapy of a wide spectrum of neurological diseases. The putative regenerating potential of these cord blood-derived neural stem/progenitor cells was evaluated after transplantation in experimental models of brain injury. In spite of initial promising data, the results indicate an urgent need to improve available animal model protocols in order to increase immuno-tolerance toward transplanted human cells.

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Section: The Cord Blood Challenge For Brain Repairmentioning

confidence: 99%

Section: The Cord Blood Challenge For Brain Repairmentioning

confidence: 99%

A novel, neural potential of non-hematopoietic human umbilical cord blood stem cells

Domanska-Janik¹,

Bużañska²,

Łukomska³

2008

Int. J. Dev. Biol.

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“…These animals are based on the first identified gene underlying familial ALS [92], and recapitulate the progressive weakness and muscle wasting associated with selective MN loss characteristic of the disease. In the earliest studies, a survival benefit was demonstrated in irradiated SOD1-G93A mice treated with human umbilical cord blood [93,94]. Follow-up studies also showed that transplanted human cord blood along with immunosuppression with cyclosporine delayed disease progression and that the transplanted cells were detected in the brain and spinal cord [25,26].…”

Section: Transitioning From Early Preclinical Studies To Current Tranmentioning

confidence: 99%

Recent Advances and the Future of Stem Cell Therapies in Amyotrophic Lateral Sclerosis

2015

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Amyotrophic lateral sclerosis is a progressive neurodegenerative disease of the motor neurons without a known cure. Based on the possibility of cellular neuroprotection and early preclinical results, stem cells have gained widespread enthusiasm as a potential treatment strategy. Preclinical models demonstrate a protective role of engrafted stem cells and provided the basis for human trials carried out using various types of stem cells, as well as a range of cell delivery methods. To date, no trial has demonstrated a clear therapeutic benefit; however, results remain encouraging and are the basis for ongoing studies. In addition, stem cell technology continues to improve, and induced pluripotent stem cells may offer additional therapeutic options in the future. Improved disease models and clinical trials will be essential in order to validate stem cells as a beneficial therapy.

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“…The collection and processing methods may render biologically distinct and dynamic cell populations in menstrual blood with stem cells being derived intraocular route for the treatment of animal models of neurodegenerative diseases such as AD, amyotrophic from the endometrial lining and the blood itself. These cells have been shown to be multipotent or even pluripolateral sclerosis (ALS), Huntington's disease (HD), and Parkinson's disease (PD) (16,(25)(26)(27)30). They observed tent cells, as they can be made to differentiate into a number of different cell types, including cardiomyoa significantly increased survival rate for these animals.…”

Section: Introductionmentioning

confidence: 99%

“…benefit in an animal model of ALS (the SOD1 transgenic mouse) with respect to survival following intraoRecent evidence suggests that while microglia are triggered to secrete proinflammatory factors by Aβ (19, cular transplant of large numbers of hUCBCs on 2 consecutive days (16,30). Since then, Garbuzova-Davis et 45,51,87), under certain conditions (such as adult stem cell transplantation) they can become "alternatively actial.…”

Section: Introductionmentioning

confidence: 99%

The Treatment of Neurodegenerative Disorders Using Umbilical Cord Blood and Menstrual Blood-Derived Stem Cells

et al. 2011

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Stem cell transplantation is a potentially important means of treatment for a number of disorders. Two different stem cell populations of interest are mononuclear umbilical cord blood cells and menstrual bloodderived stem cells. These cells are relatively easy to obtain, appear to be pluripotent, and are immunologically immature. These cells, particularly umbilical cord blood cells, have been studied as either single or multiple injections in a number of animal models of neurodegenerative disorders with some degree of success, including stroke, Alzheimer's disease, amyotrophic lateral sclerosis, and Sanfilippo syndrome type B. Evidence of anti-inflammatory effects and secretion of specific cytokines and growth factors that promote cell survival, rather than cell replacement, have been detected in both transplanted cells.

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Human umbilical cord blood effect on sod mice (amyotrophic lateral sclerosis)

Cited by 125 publications

References 0 publications

A novel, neural potential of non-hematopoietic human umbilical cord blood stem cells

A novel, neural potential of non-hematopoietic human umbilical cord blood stem cells

Recent Advances and the Future of Stem Cell Therapies in Amyotrophic Lateral Sclerosis

The Treatment of Neurodegenerative Disorders Using Umbilical Cord Blood and Menstrual Blood-Derived Stem Cells

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