Human Tuberculous Meningitis Caused by <i>Mycobacterium caprae</i>

Abstract

Introduction: Tuberculous meningitis (TM) causes substantial morbidity and mortality in humans. Human TM has been known to be induced by bacteria from the Mycobacterium tuberculosis complex(MTBC), such as M. tuberculosis and M. bovis. Case Presentation: We describe a case of meningitis treated with fosfomycin, which showed partial effectiveness in an 80-year-old patient. After a lethal myocardial infarction, M. caprae (MC) was identified in cerebrospinal fluid culture. This isolated acid-fast organism was first identified as MTBC by MTBC-specific PCR (16S rDNA-PCR). Furthermore, species-specific identification of the isolate was done by gyrB PCR-restriction fragment length polymorphism analysis of a part of gyrB DNA. Colony morphology of the isolated MC strain showed dysgonic growth on Lowenstein-Jensen medium. The strain was susceptible to pyrazinamide (PZA). Conclusion: This isolated strain was convincingly identified as MC according to the phenotypic and genotypic characteristics and PZA sensitivity. This is the first report of MC causing TM.

Peritoneal tuberculosis due to Mycobacterium caprae

“…In European countries, patients with zoonotic tuberculosis suffered more from reactivation of old infections, which mainly leads to pulmonary tuberculosis. This could explain that only few cases due to M. caprae have been reported in detail in case reports: 2 cases of cuateous tuberculosis [10] , [11] and 1 each of pericarditis case [12] , urinary tract involvement [13] and meningitis [14] .…”

Marcadores genéticos en la caracterización micobacteriana

“…El análisis del patrón de restricción obtenido sobre el producto de la amplificación del fragmento de 1020 pb de gyrB, previamente usado por Niemann, Kasai y Chimara, permitió, en primer lugar, descartar la presencia de un miembro del CMTB y, posteriormente, ubicar a la especie responsable del caso (Hansena, Seilera, Rumpfa, Krafta, Dlaskea, Abele-Hornb y Muellges, 2012).…”

Zoonotic Aspects of Tuberculosis: Disease of the past or re-emerging zoonosis?

“…caprae has been reported as a cause of tuberculosis in humans in several countries (Hansen et al 2012;Goh et al 2006;Mostowy et al 2004;Muller et al 2013;Bayraktar et al 2011a;Bayraktar et al 2011b). Other animal adapted MTBC members are less frequently involved in the development of zoonotic tuberculosis.…”

“…M. microti and M. cannettii have been described much earlier, but were for a long time believed to be pathogenic in murines and humans, respectively. Recent reports have shown that some of these organisms can infect and cause disease in other species as well and the full host range still needs to be defined (Aranaz et al 2003;van Ingen et al 2012;Alexander et al 2010;Dawson et al 2012;Hansen et al 2012;Pate et al 2006;Kiers et al 2008;Goh et al 2006;Mostowy et al 2004). …”