Human transluminally placed endovascular stented grafts: Preliminary histopathologic analysis of healing grafts in aortoiliac and femoral artery occlusive disease

Abstract

These preliminary observations on the healing of PTFE endovascular stented grafts in human beings demonstrate limited plaque hyperplasia and the presence of endothelial cells on the luminal surface remote from the graft-artery anastomosis. It is unclear whether this is a unique manifestation of healing in prosthetic grafts inserted within the walls of arteries.

Efeitos a curto prazo de "stents" não recobertos e recobertos com politetrafluoroetileno em aorta de suínos: um modelo experimental

“…Os "stents" examinados seis semanas após o implante demonstraram estar firmemente aderidos à parede arterial e apresentavam uma neoíntima bem desenvolvida na interface entre o stent e a artéria. Em uma reconstrução em falência uma estenose foi demonstrada na margem distal do stent, secundária a significativo espessamento intimal 21 . Em outro estudo, Marin e col. avaliaram a relação entre o revestimento de PTFE e o desenvolvimento de hiperplasia intimal em 12 "stents" implantados em artérias ilíacas comuns de pacientes de alto risco cirúrgi-co. O diâmetro luminal médio no segmento recoberto foi significativamente maior do que no segmento não recoberto em angiografias realizadas 4 a 6 meses após o procedimento, sugerindo que o revestimento pudesse evitar a reestenose 22 .…”

Characterization of Vascular Gene Transfer Using A Novel Cationic Lipid

“…Its relative biodegradability minimizes risks of chemical inflammation and immunologic response and enables larger doses of lipid to be used, translating into improved gene transfer. Furthermore, the quenching effect of serum on transfection provides an opportunity for site-specific gene transfer in association with the emerging uses of endovascular stent grafts [20]. Hypothetically, EDOPC-mediated transfection could be performed in the space between an impervious endovascular graft and the vascular wall and any spillover into the bloodstream would be inactivated.…”

Thoracic endovascular stent grafting inhibits aortic growth: an experimental study

“…After 3 months in situ, they found similar findings with some remodeling of the aortic wall with rearrangement of the elastic lamellae adjacent to the nitinol wires, intimal thickening and inflammatory reaction with polymorphonuclear cell invasion. Marin et al [16] studied 26 polytetrafluoroethylene-based endovascular grafts that had been implanted for 2 weeks to 7 months. In the 3-month-old specimens, they found neointimal formation and a foreign body reaction characterized by the presence of multinucleated giant cells.…”