Human tooth-size asymmetry in cleft lip with or without cleft palate

Sofaer, Joanna

doi:10.1016/0003-9969(79)90062-1

Cited by 73 publications

(56 citation statements)

References 2 publications

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“…This view is supported by analysis of individuals with congenital anomalies, like cleft palate and cleft lip, which have shown that there is an increase in fingerprint asymmetry not only in affected individuals but also in their relatives (Woolf and Gianas, 1976;1977). In agreement with these findings are the observations that persons with different genetic disorders (such as Down's syndrome and cleft palate) have significantly increased dental asymmetry (Sofaer, 1979;Barden, 1980 respectively. Ki is the sum of the RC of the ith pair of homologous fingers and QT is the total RC on both hands.…”

Section: L9nmentioning

confidence: 77%

Lerner's concept of developmental homeostasis and the problem of heterozygosity level in natural populations

Livshits

Kobyliansky

1985

Heredity

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In recent years adherents of the neutral mutation hypothesis have conducted a variety of statistical tests concerning the applicability of their theory to data of biochemical genetic polymorphism in natural populations. From the other side, the involvement of natural selection as a main evolutionary force responsible for the observed levels of polymorphism and heterozygosity have also been proposed in numerous field studies and theoretical considerations. However, none of these hypotheses completely and satisfactorily explains the collected data. We believe that one of the main causes of the discrepancy in theories is that the variability at each locus is considered independently in both of the abovementioned approaches. Yet, it was suggested long ago, and now there is an increasing amount of evidence indicating cooperation between different loci which can influence the variability at each of them. Thus we think that the use of models considering the genome as a suit of independent genes is a priori expected to decrease the efficacy of the approximation.In the present review we attempt to draw attention to findings of interdependence of the variability of different characters and its possible limiting action on the growth of genetic diversity in natural populations. We do not try to give a universal explanation for the processes acting in populations and determining levels of heterozygosity. However, to our mind, the solution of the discussed question requires consideration of genes in their interactions.

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Section: L9nmentioning

confidence: 77%

Lerner's concept of developmental homeostasis and the problem of heterozygosity level in natural populations

Livshits

Kobyliansky

1985

Heredity

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“…However, in the Class I group, we observed much more asymmetry in the dental arches (Tables 2 and 3). Sofaer 26 and Werner and Harris 2 reported high levels of tooth asymmetry between the cleft and noncleft sides in 77 patients and 63 noncleft controls. According to Sofaer,26 this generalized developmental instability is controlled genetically because patients with a positive family history showed some signs of greater asymmetry.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional tooth crown size symmetry in cleft lip and cleft palate

Akçam¹,

Aydemir²,

Özer³

et al. 2014

The Angle Orthodontist

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Objective: To evaluate and compare three-dimensional tooth size symmetry in the right and left sides of upper and lower dental arches in cleft lip and palate (CLP) patients and to compare it with an Angle Class I normal occlusion control group. ) and 53 individuals with Class I occlusion, all with permanent dentition, were randomly selected. Mesiodistal (MD), labiolingual (LL), and occlusogingival (OG) measurements of upper and lower teeth were recorded with a digital caliper. Descriptive statistics and paired t-test were used for statistical analysis. Results: Significant asymmetries were found between the right and left sides of the dental arches in CLP as follows: MD dimension: mandibular first premolar (ULCLP, P , .01); LL dimension: mandibular first premolar (URCLP, P , .05); OG dimension: maxillary central incisor and first premolar (ULCLP, P , .05 and P , .01, respectively), central incisor (BLCLP, P , .01), mandibular canine and first premolar (ULCLP, P , .01), and first molar (ULCLP, P , .05). Tooth crown size asymmetries were also recorded in the Class I group. Conclusions: Significant three-dimensional tooth size asymmetries were found in CLP subjects; however, such asymmetries were also present on the Class I control group. (Angle Orthod. 2014;84:623-627.)

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“…Previous studies have also cited that maxillary central and lateral incisors are smaller on the cleft side [11,16,19]. Sofaer [23] and Werner and Harris [7] report high levels of tooth size asymmetry between the cleft and non-cleft sides. In the mandible, analysis of the present data shows that incisors and premolars are larger on the cleft side, while the other teeth do not demonstrate any differences.…”

Section: Non-cleft Side Versus Control (Figs 6 and 7)mentioning

confidence: 97%

“…It is assumed that the same genetic and general environmental factors control development on the two sides of the body, so that the extent to which sides differ is a measure of lack of precision of this developmental control [23]. As a consequence, apart from differences in tooth size between CLP patients and the general population, differences may also be present in unilateral CLP individuals between the side with the cleft and the side without.…”

Section: Introductionmentioning

confidence: 99%

Mesiodistal tooth size in non-syndromic unilateral cleft lip and palate patients: a meta-analysis

Antonarakis

Tsiouli²,

Christou

2012

Clin Oral Invest

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Objectives To evaluate, using meta-analysis methodology, mesiodistal tooth dimensions in non-syndromic unilateral cleft lip and palate (CLP) patients. Materials and methods A literature search was conducted using PubMed, Medline, Google Scholar Beta, EMBASE Excerpta Medica, CINAHL, Web of Science, and the Cochrane Collaboration, identifying English and nonEnglish articles reporting on mesiodistal tooth dimensions on the cleft and non-cleft side of non-syndromic unilateral CLP patients. Additional studies were identified by searching reference lists of articles consulted. Only studies with a suitable control group were included. Two examiners independently performed the literature search and data extraction. Using meta-analysis software, data extracted from each selected study were statistically combined using the fixedeffects model. Weighted mean differences, 95 % confidence intervals, and heterogeneity were calculated for each measurement.Results Four articles fulfilling the inclusion criteria were located and included in the meta-analysis. Maxillary incisors and first molars were found to be significantly larger on the non-cleft side while mandibular incisors and premolars were larger on the cleft side, in nonsyndromic unilateral CLP patients. On the cleft side, maxillary premolars and second molars were larger in cleft than control patients while incisors were smaller, whereas all mandibular teeth were larger in cleft patients. On the non-cleft side, all maxillary teeth except for the central incisors were larger in the cleft than control patients, while all mandibular teeth were larger in the cleft patients except for lateral incisors. Conclusions Non-syndromic unilateral CLP patients tend to have larger posterior but smaller anterior teeth compared with the general population. Comparing sides, unilateral CLP patients tend to have smaller maxillary but larger mandibular teeth on the cleft than on the non-cleft side. Clinical relevance Given that obtaining a stable, functional, and esthetic occlusion requires a thorough evaluation of tooth size, knowledge about trends in tooth size variations in CLP patients can help with dental and orthodontic treatment planning.

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Human tooth-size asymmetry in cleft lip with or without cleft palate

Cited by 73 publications

References 2 publications

Lerner's concept of developmental homeostasis and the problem of heterozygosity level in natural populations

Lerner's concept of developmental homeostasis and the problem of heterozygosity level in natural populations

Three-dimensional tooth crown size symmetry in cleft lip and cleft palate

Mesiodistal tooth size in non-syndromic unilateral cleft lip and palate patients: a meta-analysis

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