Human T‐lymphotropic virus type I and type II infections and correlation with risk factors in blood donors from São Paulo, Brazil

Ferreira, Orlando C.; Vaz, Rogério Saad; Carvalho, M. B.; Guerra, Cristina Tosti; Fabron, Antonio; J, Rosemblit; Hamerschlak, Nelson

doi:10.1046/j.1537-2995.1995.35395184284.x

Cited by 36 publications

(8 citation statements)

References 20 publications

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“…HTLV-1 infection is endemic in some areas of Brazil [Ferreira et al, 1995], and co-infection with human immunodeficiency virus type 1 (HIV-1) occasionally occurs, with the highest risk for intravenous drug users, although sexual transmission may be the route in 1-2% of co-infected patients, mainly homosexual males [de Araujo et al, 1994].…”

Section: Introductionmentioning

confidence: 99%

Presence of tropical spastic paraparesis/human T‐cell lymphotropic virus type 1‐associated myelopathy (TSP/HAM)‐like among HIV‐1‐infected patients

Casseb

Oliveira

Vergara

et al. 2008

Journal of Medical Virology

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A total of 38 HIV-1/HTLV-1 co-infected subjects were identified in this cohort: Twenty-six had already been diagnosed with AIDS and 12 remained asymptomatic. Six of 38 co-infected subjects (18%) were diagnosed as having TSP/HAM and also AIDS, and for 5 of them TSP/HAM was their first illness. One additional incident case was diagnosed after 2 years of follow-up. No modifications on HIV-1 viral load was seen. In contrast, the co-infected with TSP/HAM-like group showed higher HTLV-1 proviral load (505 +/- 380 vs. 97 +/- 149 copies/10(4) PBMC, P = 0.012) than asymptomatic co-infected subjects, respectively. The incidence of myelopathy among HIV-1/HTLV-1 co-infected subjects is probably higher than among patients infected only with HTLV-1, and related to a higher HTLV-1 proviral load. Thus, HTLV-1/2 screening should be done for all HIV-1-infected patients in areas where HTLV-1 infection is endemic.

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Section: Introductionmentioning

confidence: 99%

Presence of tropical spastic paraparesis/human T‐cell lymphotropic virus type 1‐associated myelopathy (TSP/HAM)‐like among HIV‐1‐infected patients

Casseb

Oliveira

Vergara

et al. 2008

Journal of Medical Virology

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“…In-depth investigation of these characteristics may reveal particularly relevant information about the risk of viral acquisition, as well as about the pathogenetic impact of coinfection on HCV and/or HTLVassociated disease development. So far, virus-host interactions in coinfected individuals have been reported to be associated with dysfunctional cell immune response, which might impair HCV clearance and lead to accelerated progression of HCV liver disease 12 27 29 .…”

mentioning

confidence: 99%

Hepatitis C virus and human T-lymphotropic virus coinfection: epidemiological, clinical, laboratory and histopathological features

Milagres

Duarte

Viso

et al. 2009

Rev. Soc. Bras. Med. Trop.

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Twenty-four hepatitis C virus patients coinfected with human T-lymphotropic virus type 1 were compared with six coinfected with HTLV-2 and 55 with HCV alone, regarding clinical, epidemiological, laboratory and histopathological data. Fischer's discriminant analysis was applied to define functions capable of differentiating between the study groups (HCV, HCV/HTLV-1 and HCV/HTLV-2). The discriminant accuracy was evaluated by cross-validation. Alcohol consumption, use of intravenous drugs or inhaled cocaine and sexual partnership with intravenous drug users were more frequent in the HCV/HTLV-2 group, whereas patients in the HCV group more often reported abdominal pain or a sexual partner with hepatitis. Coinfected patients presented higher platelet counts, but aminotransferase and gamma-glutamyl transpeptidase levels were higher among HCV-infected subjects. No significant difference between the groups was seen regarding liver histopathological findings. Through discriminant analysis, classification functions were defined, including sex, age group, intravenous drug use and sexual partner with hepatitis. Cross-validation revealed high discriminant accuracy for the HCV group. Key-words:Hepatitis C virus. Human T-lymphotropic virus type 1. Human T-lymphotropic virus type 2. Epidemiological studies. Discriminant analysis. RESUMOCompararam-se 24 pacientes coinfectados pelos vírus da hepatite C/vírus linfotrópico de células T humanas do tipo 1 com 6 coinfectados por VHC/ HTLV-2 e 55 infectados pelo VHC, no tocante a dados clínico-epidemiológicos, laboratoriais e histopatológicos. A análise discriminante de Fischer foi utilizada para definir funções capazes de diferenciar os grupos de estudo (VHC, VHC/HTLV-1 e VHC/HTLV-2). A acurácia discriminatória foi avaliada pelo por validação cruzada. O uso de álcool, drogas endovenosas, cocaína inalatória e a parceria sexual com UDEV foram mais freqüentes no grupo VHC/HTLV-2, enquanto queixa de dor abdominal e parceiro sexual com hepatite predominaram no grupo VHC. Os coinfectados apresentaram número maior de plaquetas, enquanto as aminotransferases e a gamaglutamiltranspeptidase foram mais altas no grupo VHC. Não houve diferença entre os grupos à análise histopatológica do fígado. Por análise discriminante definiram-se funções classificatórias, incluindo as variáveis sexo, faixa etária, uso de drogas endovenosas e parceiro sexual com hepatite, com acurácia discriminante alta para o grupo VHC. Palavras-chaves:Vírus da hepatite C. Vírus linfotrópico de células T humanas do tipo 1. Vírus linfotrópico de células T humanas do tipo 2. Estudos epidemiológicos. Análise discriminante.

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“…5 Ocular manifestations that have been described in HTLV-1-infected individuals include opportunistic infection and tumor infiltration of the eye and orbit in patients with ATLL [6][7][8] ; retinal microvascular changes, intraocular inflammatory disturbances, retinochoroidal degeneration, and keratoconjunctivitis sicca (KCS) in patients with HAM-TSP 7,[9][10][11][12] ; and HTLV-1-associated uveitis (HU) in asymptomatic carriers. 7,9,[13][14][15][16] Seroepidemiological surveys of highrisk groups 17,18 and blood donors from different parts of Brazil 19,20 show relatively high HTLV-1 seroprevalence rates compared with nonendemic areas such as the United States. The highest prevalence rate of HTLV-1 infection among healthy subjects has been found in Northeastern Brazil (1.8%).…”

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confidence: 99%

Human T-Cell Lymphotropic Virus Type 1 Infection and Ocular Manifestations in São Paulo, Brazil

Yamamoto¹

1999

Arch Ophthalmol

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Although human T-cell lymphotropic virus type 1 (HTLV-1)-associated uveitis has been well recognized in Japan, related studies in Brazil are scarce. We performed a serologic survey for HTLV-1 infection among patients with uveitis and investigated the ocular findings in HTLV-1-asymptomatic carriers.Methods: One hundred ninety serum samples from patients with uveitis of determined (n = 137) and undetermined origins (n = 53

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Human T‐lymphotropic virus type I and type II infections and correlation with risk factors in blood donors from São Paulo, Brazil

Abstract: Both HTLV-I and HTLV-II occur among Brazilian blood donors. HTLV-I is associated with Asian ethnicity, greater age, and the presence of anti-HCV and anti-HBc. Three HTLV-I-positive donors had a history of blood transfusion, which emphasizes the need for HTLV-I/II screening in Brazil.

Cited by 36 publications

References 20 publications

Presence of tropical spastic paraparesis/human T‐cell lymphotropic virus type 1‐associated myelopathy (TSP/HAM)‐like among HIV‐1‐infected patients

Presence of tropical spastic paraparesis/human T‐cell lymphotropic virus type 1‐associated myelopathy (TSP/HAM)‐like among HIV‐1‐infected patients

Hepatitis C virus and human T-lymphotropic virus coinfection: epidemiological, clinical, laboratory and histopathological features

Human T-Cell Lymphotropic Virus Type 1 Infection and Ocular Manifestations in São Paulo, Brazil

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