Human T-lymphotropic virus type 1 infection is frequent in rural communities of the southern Andes of Peru

Ita, Fanny; Mayer, Erick F.; Verdonck, Kristien; González, Elsa; Clark, Daniel; Gotuzzo, Eduardo

doi:10.1016/j.ijid.2013.10.005

Cited by 24 publications

(21 citation statements)

References 29 publications

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“…The implication of prolonged lactation was also demonstrated in Peru in an investigation of 120 HTLV-1-infected mothers. In that study, the overall prevalence of infection was 23.3% (28/120) among children breastfed less than six months and 32.6% (23/76) in those breastfed for more than 6 months [34]. …”

Section: Discussionmentioning

confidence: 99%

Silent dissemination of HTLV-1 in an endemic area of Argentina. Epidemiological and molecular evidence of intrafamilial transmission

et al. 2017

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BackgroundMolecular and epidemiological studies of transmission routes and risk factors for infection by HTLV-1 are extremely important in order to implement control measures, especially because of the high prevalence of HTLV-1 in several regions of the world. San Salvador de Jujuy, Northwest Argentina, is a highly endemic area for HTLV-1 and foci of tropical spastic paraparesis/HTLV-1-associated myelopathy.ObjectiveTo gain further insight into the role of intrafamilial transmission of HTLV-1 in a highly endemic region in Argentina.MethodCross-sectional study in Northwest Argentina. Epidemiological data and blood samples were collected from 28 HTLV-1 infected subjects (index cases) and 92 close relatives/cohabitants. HTLV-1 infection was diagnosed by detection of antibodies and proviral DNA. The LTR region was sequenced and analyzed for genetic distances (VESPA software), in addition to determination and identification of polymorphisms to define HTLV-1 family signatures.ResultsFifty seven of the 120 subjects enrolled had antibodies against HTLV-1 and were typified as HTLV-1 by PCR. The prevalence rate of HTLV-1 infection in family members of infected index cases was 31.52% (29/92). The infection was significantly associated with gender, age and prolonged lactation. Identity of LTR sequences and presence of polymorphisms revealed high prevalence of mother-to-child and interspousal transmission of HTLV-1 among these families.ConclusionThere is an ongoing and silent transmission of HTLV-1 through vertical and sexual routes within family clusters in Northwest Argentina. This evidence highlights that HTLV-1 infection should be considered as a matter of public health in Argentina, in order to introduce preventive measures as prenatal screening and breastfeeding control.

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Section: Discussionmentioning

confidence: 99%

Silent dissemination of HTLV-1 in an endemic area of Argentina. Epidemiological and molecular evidence of intrafamilial transmission

et al. 2017

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“…Europa ha reportado casos en Francia, Reino Unido, Rumania y España; en este último país se informaron 253 casos de HTLV-1 hacia finales del año 2013 (20,24). Con respecto a Sudaméri-ca, se han informado casos en Brasil, Perú, Venezuela, Argentina y Colombia, y es más frecuente encontrarlo en personas con raíces africanas o en poblaciones indígenas (25)(26)(27)(28).…”

Section: Epidemiologíaunclassified

Infección por el virus linfotrópico humano de células T tipo 1 (HTLV-1) y paraparesia espástica. Avances y diagnóstico 35 años después de su descubrimiento

Rivera-Caldón

López-Valencia

Zamora-Bastidas

et al. 2017

iatreia

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“…Se han reportado prevalencias de infección por HTLV-1 de hasta 2,3% en gestantes asintomáticas procedentes de los departamentos de Lima, Ayacucho y Cusco (1,3,4) ; estos reportes ganan importancia ya que un estudio realizado en Lima durante el año 2007 encontró en hijos de madres seropositivas a HTLV-1, 52 casos confirmados de una población de 279 madres infectadas (1) .…”

Section: Mensajes Claveunclassified

Rendimiento diagnóstico de la prueba de inmunofluorescencia indirecta para la detección de anticuerpos contra HTLV-1

Romero-Ruiz

Miranda-Ulloa

Briceño-Espinoza

2017

Rev Peru Med Exp Salud Publica

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RESUMENEl objetivo del estudio fue determinar el rendimiento diagnóstico de la prueba de inmunofluorescencia indirecta (IFI) para la detección de anticuerpos contra HTLV-1. Se realizó un estudio de evaluación de prueba diagnóstica. Se usaron cultivos celulares MT2 infectados con HTLV-1 y K-562 sin infección, luego fueron sembrados, fijados en láminas para inmunofluorescencia y enfrentados a sueros. Se usaron 155 sueros (80 positivos para HTLV-1 y 75 positivos para otras enfermedades) procedentes de la seroteca del Instituto Nacional de Salud del Perú. Adicionalmente, se evaluó la repetibilidad (en el laboratorio) y reproducibilidad (en laboratorios de costa, sierra y selva) de la prueba. La prueba IFI para la detección de anticuerpos contra HTLV-1 tuvo una sensibilidad de 98,75% (IC 95%: 95,69-100%), una especificidad de 98,67% (IC 95%: 95,40-100%) y el índice de kappa de 0,975. No hubo falsos positivos ni falsos negativos; sin embargo, sí se obtuvo un resultado indeterminado y uno inespecífico. La prueba mostró 100% de concordancia en la repetibilidad y reproductibilidad. Concluimos que los resultados obtenidos son comparables a la prueba de referencia. La prueba de IFI presenta un buen rendimiento diagnóstico y sería de utilidad para la confirmación de HTLV-1. Palabras clave: Virus 1 linfotrópico T humano; Diagnóstico, Técnica del anticuerpo fluorescente indirecta, (fuente: DeCS BIREME) DIAGNOSTIC PERFORMANCE OF THE INDIRECT IMMUNOFLUORESCENCE TEST FOR THE DETECTION OF ANTIBODIES AGAINST HTLV-1 ABSTRACTThe objective of the study was to determine the diagnostic yield of the indirect immunofluorescence (IFI) test for the detection of antibodies against HTLV-1. A diagnostic test evaluation study was performed. HTLV-1-infected MT2 cells and HTLV-1-uninfected K-562 cells were cultured; then these cells were impregnated and fixed in sheets for immunofluorescence and faced to Peruvian sera. A total of 155 sera (80 HTLV-1-positive sera and 75 sera positive for other diseases) from the Peruvian Instituto Nacional de Salud were used. In addition, the parameters of repeatability (intra-laboratory) and reproducibility (in laboratories of the Peruvian coast, mountains and jungle) of the test were evaluated. The IFI test detected the presence of antibodies against HTLV-1 reaching a sensitivity of 98.75% (95% CI: 95.69 -100.00%), a specificity of 98.67% (95% CI: 95.40 -100.00%) and the Kappa index was 0.975. There were no false positives or false negatives; however, one undetermined result and one non-specific result were obtained. The test showed 100% qualitative agreement when performing the repeatability and reproducibility. The results obtained are comparable to the reference test. Therefore, the IFI test had a good diagnostic performance and would be useful for the confirmation of HTLV-1. Key words: Human T-lymphotropic virus 1; Diagnosis, Fluorescent antibody technique, indirect, (source: DeCS BIREME) INTRODUCCIÓNA nivel mundial, el Caribe, Japón y algunos países de Sudamérica (entre ellos el Perú) y África son endémic...

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Human T-lymphotropic virus type 1 infection is frequent in rural communities of the southern Andes of Peru

Abstract: The fact that HTLV-1 infection was present in two out of three provinces suggests that HTLV-1 could be highly endemic in the southern Andes in the Quechua population.

Cited by 24 publications

References 29 publications

Silent dissemination of HTLV-1 in an endemic area of Argentina. Epidemiological and molecular evidence of intrafamilial transmission

Silent dissemination of HTLV-1 in an endemic area of Argentina. Epidemiological and molecular evidence of intrafamilial transmission

Infección por el virus linfotrópico humano de células T tipo 1 (HTLV-1) y paraparesia espástica. Avances y diagnóstico 35 años después de su descubrimiento

Rendimiento diagnóstico de la prueba de inmunofluorescencia indirecta para la detección de anticuerpos contra HTLV-1

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