Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age

Martins, Adenilda Lima Lopes; Grassi, Maria Fernanda Rios; Firmino, Alisson de Aquino; Araujo, Jean Paulo Lacerda; Paixão, Taiane Silva; Galvão–Castro, Bernardo; Boa-Sorte, Ney

doi:10.1016/j.esxm.2018.07.002

Cited by 11 publications

(11 citation statements)

References 43 publications

(53 reference statements)

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“…Available data on HTLV-1 infection show that black/mixed ethnicities, with low income and education level, are those more frequently infected [ 2 ]. Women are mostly affected, are more susceptible to sexual transmission, and have greater risk of HAM [ 22 , 79 ]. In addition, they carry the burden of transmitting the virus to their children.…”

Section: A Neglected Virus Affecting a Neglected Population Needs An Integrated Strategy To Prevent Its Spreadmentioning

confidence: 99%

Blocking HTLV-1/2 silent transmission in Brazil: Current public health policies and proposal for additional strategies

et al. 2021

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Human T-cell lymphotropic viruses 1 and 2 (HTLV-1/2) are relatively common in Brazil but remain silent and neglected infections. HTLV-1 is associated with a range of diseases with high morbidity and mortality. There is no curative treatment for this lifelong infection, so measures to prevent transmission are essential. This narrative review discusses HTLV-1/2 transmission routes and measures to prevent its continuous dissemination. The public health policies that are currently implemented in Brazil to avoid HTLV-1/2 transmission are addressed, and further strategies are proposed.

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Section: A Neglected Virus Affecting a Neglected Population Needs An Integrated Strategy To Prevent Its Spreadmentioning

confidence: 99%

Blocking HTLV-1/2 silent transmission in Brazil: Current public health policies and proposal for additional strategies

et al. 2021

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“…There are limited data on the impact of HTLV-1 on fertility and on assisted reproduction. While HTLV-1 infection can be associated with erectile dysfunction in up to 55.2% men (Caskey et al, 2007; Oliveira et al, 2010; de Oliveira et al, 2017) and with sexual dysfunction in women (Lopes Martins et al, 2018), no differences in the prevalence of HTLV-1 infection according to the fertility status was observed in women from Gabon (Schrijvers et al, 1991). One study about assisted reproduction from Iran, evaluated 32 cycles from HTLV-1 positive women and when comparing to an age matched control group no differences were found among fertilization, implantations, pregnancy rate, number of transferred and cryopreserved embryos, multiple pregnancies nor in abortion rates (Torshizi et al, 2014).…”

Section: Htlv-1 Infection In Pregnant Womenmentioning

confidence: 99%

Mother-to-Child HTLV-1 Transmission: Unmet Research Needs

Rosadas

Taylor

2019

Front. Microbiol.

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Mother-to-child transmission (MTCT) of Human T-cell lymphotropic virus type 1 (HTLV-1) causes lifelong infection. At least 5–10 million individuals worldwide are currently living with HTLV-1. Studies of regional variation are required to better understand the contribution of MTCT to the global burden of infection. Although most infected individuals remain asymptomatic ∼10% develop high morbidity, high mortality disease. Infection early in life is associated with a higher risk of disease development. Adult T-cell leukemia (ATL), which is caused by HTLV-1 and has a median survival of 8 months is linked to MTCT, indeed evidence of ATL following infection as an adult is sparse. Infective dermatitis also only occurs following neonatal infection. Whilst HTLV-1-associated myelopathy (HAM) follows sexual and iatrogenic infection approximately 30% of patients presenting with HAM/TSP acquired the infection through their mothers. HAM/TSP is a disabling neurodegenerative disease that greatly impact patient’s quality of life. To date there is no cure for HTLV-1 infection other than bone marrow transplantation for ATL nor any measure to prevent HTLV-1 associated diseases in an infected individual. In this context, prevention of MTCT is expected to contribute disproportionately to reducing both the incidence of HTLV-1 and the burden of HTLV-1 associated diseases. In order to successfully avoid HTLV-1 MTCT, it is important to understand all the variables involved in this route of infection. Questions remain regarding frequency and risk factors for in utero peri-partum transmission whilst little is known about the efficacy of pre-labor cesarean section to reduce these infections. Understanding the contribution of peripartum infection to the burden of disease will be important to gauge the risk-benefit of interventions in this area. Few studies have examined the impact of HTLV-1 infection on fertility or pregnancy outcomes nor the susceptibility of the mother to infection during pregnancy and lactation. Whilst breast-feeding is strongly associated with transmission and avoidance of breast-feeding a proven intervention little is known about the mechanism of transmission from the breast milk to the infant and there have been no clinical trials of antiretroviral therapy (ARV) to prevent this route of transmission.

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“…No Brasil, há aproximadamente 2,5 milhões de infectados sendo o território com o maior número absoluto de casos, sobretudo nas regiões Norte e Nordeste. As principais formas de transmissão do HTLV-1 são por via parental, amamentação e predominantemente por intercurso sexual com risco de 61% maior para a infecção de mulheres [3][4][5].…”

Section: Introductionunclassified

“…Pacientes com PET/MAH podem apresentar distúrbios urinários e disfunção sexual. Queixas urinárias são encontradas em praticamente todos os indivíduos com PET/MAH e em cerca de 14% dos indivíduos HTLV-1 sem PET/MAH sendo essas manifestações um sinal de importante evolução do vírus e aumento da gravidade da infecção viral [5,6].…”

Section: Introductionunclassified

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Influência de um protocolo de fisioterapia pélvica na função urinária e sexual de mulheres infectadas com vírus linfotrópico de células T humano tipo 1

Lemos¹,

Nogueira²,

Bendelack³

et al. 2020

Fisioter Bras

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Objetivo: Avaliar a influência da fisioterapia pélvica na função urinária e sexual de mulheres infectadas com HTLV-1. Métodos: Estudo quasi-experimental, com protocolo de 16 sessões em nove mulheres, que foram categorizadas em grupo sintomático e assintomático. Realizou-se teste de força muscular do assoalho pélvico com esquema PERFECT modificado, aplicou-se os questionários King's Health Questionnaire (KHQ) e Female Sexual Function Index (FSFI). O protocolo de fisioterapia pélvica consistiu em eletroestimulação do nervo tibial, eletroestimulação transvaginal e exercícios de cinesioterapia pélvica. Resultados: No grupo assintomático, segundo esquema PERFECT houve melhora da Endurance e Resistência do assoalho pélvico. No KHQ, verificou-se melhora geral no impacto da incontinência na qualidade de vida. No FSFI, houve aumento significativo no escore geral (p = 0,01), com influência nos domínios Desejo, Excitação, Lubrificação e Orgasmo. No grupo sintomático, o esquema PERFECT obteve melhora significativa em todos os domínios, assim como nos domínios de Limitação física, Sono/Energia e Medidas de Gravidade do KHQ e dos domínios de Desejo, Excitação e o Escore geral (p = 0,01) do FSFI. Conclusão: Sugere-se que o programa de fisioterapia pélvica aplicado melhorou a funcionalidade do assoalho pélvico, a qualidade de vida, reduziu os sintomas urinários e aprimorou a função sexual.Palavras-chave: vírus linfotrópico T tipo 1 humano, Fisioterapia, incontinência urinária.

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Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age

Cited by 11 publications

References 43 publications

Blocking HTLV-1/2 silent transmission in Brazil: Current public health policies and proposal for additional strategies

Blocking HTLV-1/2 silent transmission in Brazil: Current public health policies and proposal for additional strategies

Mother-to-Child HTLV-1 Transmission: Unmet Research Needs

Influência de um protocolo de fisioterapia pélvica na função urinária e sexual de mulheres infectadas com vírus linfotrópico de células T humano tipo 1

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Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age

Cited by 11 publications

References 43 publications

Blocking HTLV-1/2 silent transmission in Brazil: Current public health policies and proposal for additional strategies

Blocking HTLV-1/2 silent transmission in Brazil: Current public health policies and proposal for additional strategies

Mother-to-Child HTLV-1 Transmission: Unmet Research Needs

Influência de um protocolo de fisioterapia pélvica na função urinária e sexual de mulheres infectadas com ví­rus linfotrópico de células T humano tipo 1

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Influência de um protocolo de fisioterapia pélvica na função urinária e sexual de mulheres infectadas com vírus linfotrópico de células T humano tipo 1