Human T-Cell Lymphotropic Virus Type I (Htlv-I) Seroepidemiology and Risk Factors in Metropolitan Panamá

Reeves, W. C.; Saxinger, Carl; Brenes, Maria M.; Quiroz, Evelia; Clark, Jeffrey W.; Hoh, Mei-Wan; Blattner, William A.

doi:10.1093/oxfordjournals.aje.a114828

Cited by 41 publications

(17 citation statements)

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“…Epidemiologic surveys have identified regions, such as southern Japan 2,3 , the Caribbean 4 , South and Central America 5,6 and regions of Africa, where the prevalence of HTLV-I is high, then been considered endemic regions. One survey conduced in Brazil revealed that the prevalence of HTLV-I in this country is high, particularly among homosexual and bisexual men, female prostitutes, patients with AIDS, and men with hemophilia 7 .…”

Section: Discussionmentioning

confidence: 99%

Inflammatory myopathy on HTLV-I infection: case report

Scola

Werneck

Heinig

et al. 2001

Arq. Neuro-Psiquiatr.

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We describe a 41 years old woman who 17 years ago presented hypotonia and proximal muscular weakness in the upper and lower limbs. On neurological examination, the biceps, triceps and Achilles reflexes were absent; the brachioradialis reflexes were decreased and the patellar reflexes were normal. There was bilateral Babinski sign. The remainder of the neurological examination was unremarkable. In the investigation a myopathic pattern was found in the electromyography. The nerve-conduction study was normal; a ELISA method for HTLV-I antibodies was positive in the blood and in the cerebral spinal fluid. The muscle biopsy showed inflammatory myopathy, compatible with polymyositis. This paper focuses the polymyositis in the beginning of an HTLV-I infection case.KEY WORDS: HTLV-I, polymyositis, inflammatory myopathy.Miopatia inflamatória em infecção por HTLV-I: relato de caso RESUMO Descrevemos o caso de uma paciente que há 17 anos iniciou sua doença com hipotonia e diminuição da força muscular proximal nos membros superiores e inferiores. No exame neurológico apresentava arreflexia bicipital e tricipital, hiporreflexia estilorradial e reflexo patelar normal; sinal de Babinski bilateral. O restante do exame neurológico era normal. Na eletromiografia de agulha foi encontrado padrão miopático. O exame de condução nervosa estava normal. A pesquisa pelo método ELISA de anticorpos anti-HTLV-I foi positiva no sangue e no líquido cefalorraquidiano. A biópsia muscular mostrou miopatia inflamatória, compatível com polimiosite. O presente artigo enfoca a polimiosite na abertura do quadro clínico de uma infecção pelo HTLV-I. PALAVRAS-CHAVE: HTLV-I, polimiosite, miopatia inflamatória. Several syndromes have been associated to the HTLV-I. In neurology, the most frequent picture is the called HTLV-I associated myelopathy / tropical spastic paraparesis. Associated to this, more recently has been described the HTLV-I polymyositis 1 , and there are also a few cases of polymyositis alone. This paper reports a case of a patient who started with polymyositis and later developed a myelopathy with HTLV-I antibody positive. CASEA 41 years old white woman presented, since 1983, proximal muscle weakness of her left lower limb, and 6 months later also of the right side, with progressive worsening. After 5 years she presented proximal muscle weakness of both upper limbs. There were no sensitive disturbances or urinary incontinence. She also presented moderate myalgia and had several types of treatment without satisfactory result. She was treated with prednisone in the last 3 year and at time of evaluation was taking 5mg/day. She had a past history of hepatitis when was 19 years-old, urinary infection, apendicectomy and had received a blood transfusion.The neurological examination showed mental and cranial nerves examination with no involvement. There was not muscle atrophy. There was hipotonia in the four limbs. Weakness was presented in the four limbs, and was more prominent in the proximal groups (3/5) than in the distal ones (4/5)....

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Section: Discussionmentioning

confidence: 99%

Inflammatory myopathy on HTLV-I infection: case report

Scola

Werneck

Heinig

et al. 2001

Arq. Neuro-Psiquiatr.

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“…Human T-lymphotropic virus type 1 (HTLV-1) infection is endemic in southwestern Japan (Hinuma et al, 1982;Blattner et al, 1983), the Caribbean islands (Blattner et al, 1982), Central and South America (Reeves et al, 1988;Maloney et al, 1989), some parts of Africa (Saxinger et al, 1984), and the Northeast of Iran (Rafatpanah et al, 2011). The best estimate of HTLV-1 worldwide prevalence from the mid-nineties is 10 to 20 million (de The and Bomford, 1993).…”

Section: Introductionmentioning

confidence: 99%

The impact of interferon-alpha treatment on clinical and immunovirological aspects of HTLV-1-associated myelopathy in northeast of Iran

Rafatpanah¹,

Rezaee²,

Etemadi³

et al. 2012

Journal of Neuroimmunology

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“…Most of HTLV-I infected individuals remain asymptomatic throughout their lives and in a few subjects HTLV-I-associated diseases develop. The virus is endemic in different regions such as south west of Japan (3), the Caribbean islands (4), Central and South America (5), and some parts of Africa (6). We have previously reported that HTLV-I is endemic in north-east of Iran, particularly in the cities of Mashhad, Sabzevar, and Neishbour.…”

Section: Introductionmentioning

confidence: 99%