Human T-Cell Leukemia-Lymphoma Virus (HTLV): A Progress Report

Gallo, Robert C.; Popovic, M; Sarin, Prem S.; Reitz, M. S.; Kalyanaraman, V. S.; Aoki, Tadao; Sarngadharan, M. G.; Wong‐Staal, Flossie

doi:10.1007/978-3-642-68761-7_61

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…Human T-cell leukemia virus type I (HTLV-I) is an exogenous retrovirus, etiologically associated with adult T-cell leukemia lymphoma (1)(2)(3). HTLV-I is a member of a family of retroviruses that includes simian T-cell leukemia virus type I (4), human T-cell leukemia virus type II (HTLV-II) (5), and bovine leukemia virus (6).…”

mentioning

confidence: 99%

Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancer.

Paskalis¹,

Felber²,

Pavlakis³

1986

Proc. Natl. Acad. Sci. U.S.A.

168

144

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mentioning

confidence: 99%

Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancer.

Paskalis¹,

Felber²,

Pavlakis³

1986

Proc. Natl. Acad. Sci. U.S.A.

168

144

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“…Bovine leukemia virus (BLV) is a type C retrovirus which causes a malignancy of B-cell lineage termed enzootic bovine leukosis in cattle, and shares biological and pathological properties with human T-lymphotropic leukemia virus types I and II (HTLV-I, -II) (1,5,10). Determination of the complete nucleotide sequences of these viruses (16)(17)(18)(19) revealed that the organization of their genes is similar.…”

mentioning

confidence: 99%

Augmentation of Bovine Leukemia Virus (BLV)‐Specific Lymphocyte Proliferation Responses in Ruminants by Inoculation with BLVenv‐Recombinant Vaccinia Virus: Their Role in the Suppression of BLV Replication

Ohishi¹,

Suzuki²,

Yasutomi

et al. 1992

Microbiology and Immunology

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Lymphocyte proliferation responses were investigated in sheep and cattle, in which the replication of bovine leukemia virus (BLV) had been known to be suppressed by inoculation with recombinant vaccinia virus (rVV) expressing BLV envelope glycoprotein (gp60). Enhanced lymphocyte proliferation responses were observed in animals inoculated with rVV, regardless of whether they were naive or BLV carriers. These responses were roughly inversely correlated to the growth of BLV in the peripheral blood leukocytes. In contrast, there was no apparent correlation between humoral immune response and BLV growth. Based on these results, it was suggested that rVV rendered its suppressive effect of BLV replication primarily via augmentation of cell-mediated immunity.Bovine leukemia virus (BLV) is a type C retrovirus which causes a malignancy of B-cell lineage termed enzootic bovine leukosis in cattle, and shares biological and pathological properties with human T-lymphotropic leukemia virus types I and II (HTLV-I, -II) (1, 5, 10). Determination of the complete nucleotide sequences of these viruses (16)(17)(18)(19) revealed that the organization of their genes is similar. BLV infection usually occurs horizontally and is characterized by a long latent period. It also induces leukemia in sheep at a high incidence within a relatively short period (7, 13), making sheep a good animal model for research on BLV.An increasing amount of data show that the induction of strong humoral immune response to BLV envelope glycoprotein was able to completely protect naive sheep against BLV infection (8,14). Our knowledge is sparse, however, of the immunological mechanisms controlling the replication of BLV after its infection of an animal. To investigate this, we conducted a series of experiments in sheep 131 7

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“…It is believed that an etiological agent of adult T-cell leukemia (ATL) is a human retrovirus designated as human T-cell leukemia virus type I (HTLV-I) (Poiesz et al 1980;Hinuma et al 1981;Yoshida et al 1982;Gallo et al 1983). Leukemia cells of ATL patients contain the HTLV-I provirus DNA integrated into their chromosomal DNA (Yoshida et al 1982), and cells of some established cell lines carrying HTLV-I have several HTLV-I-specific antigens recognized by the sera of ATL patients, which have been named ATL-associated antigens (ATLAS) (Hinuma et al 1981).…”

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confidence: 99%

Monoclonal antibody defining Tax1 protein of human T-cell leukemia virus type-I.

Lee

Tanaka

Tozawa

1989

Tohoku J. Exp. Med.

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We prepared a monoclonal antibody (MAb), Lt-4, which recognizes a tax protein expressed in HTLV-I-infected cells. Indirect immunofluorescence staining showed that the antigen recognized by Lt-4 MAb located mainly in the nuclei of HTLV-I-infected T cell lines such as HUT102, TCL-As2, MT-1 and MT-2, and also weakly in the cytoplasm of MT-2 cell line. Lt-4 MAb did not react with two HTLV-I-uninfected T cell lines tested and fresh and PHA-activated peripheral blood lymphocytes (PBL) of several normal donors. Furthermore, Lt-4 MAb stained the nuclei of HeLa cells infected with a recombinant vaccinia virus encoding the tax but not with a wild type vaccinia virus. In Western blot (WB) and radioimmunoprecipitation analyses, Lt-4 MAb detected a 40 kDa molecule (p40) in HUT102 and TCL-As2 cells, and p40 and p68 in MT-2 cells. These results show that Lt-4 MAb is highly specific for the tax protein.

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Human T-Cell Leukemia-Lymphoma Virus (HTLV): A Progress Report

Cited by 5 publications

References 26 publications

Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancer.

Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancer.

Augmentation of Bovine Leukemia Virus (BLV)‐Specific Lymphocyte Proliferation Responses in Ruminants by Inoculation with BLVenv‐Recombinant Vaccinia Virus: Their Role in the Suppression of BLV Replication

Monoclonal antibody defining Tax1 protein of human T-cell leukemia virus type-I.

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