Human T-cell activation withToxoplasma gondiiantigens loaded in maltodextrin nanoparticles
Laura García-López,
Alejandro Zamora-Vélez,
Mónica Vargas-Montes
et al.
Abstract:Toxoplasmosis is the most prevalent parasitic zoonosis worldwide, causing ocular and neurological diseases. No vaccine has been approved for human use. We evaluated the response of peripheral blood mononuclear cells (PBMCs) to a novel construct ofToxoplasma gondiitotal antigen in maltodextrin nanoparticles (NP/TE) in individuals with varying infectious statuses (uninfected, chronic asymptomatic, or ocular toxoplasmosis). We analyzed the concentration of IFN-γ after NP/TE ex vivo stimulation using ELISA and the… Show more
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