Human Spumaretrovirus in the Etiology of Sudden Hearing Loss

Pyykkö, I; Vesanen, Mika; Asikainen, Kari; Koskiniemi, Marjaleena; Airaksinen, Liisa; Vaheri, A

doi:10.3109/00016489309135776

Cited by 17 publications

(8 citation statements)

References 12 publications

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“…In both studies the authors were unable to find FV seroreactivity in 71 samples tested. A number of unconfirmed reports, largely based on single assays, have implicated FV infection in familial Mediterranean fever (113), sensorineural hearing loss (84), and dialysis encephalopathy (22).…”

Section: Other Diseasesmentioning

confidence: 99%

Historical Perspective of Foamy Virus Epidemiology and Infection

2001

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Foamy viruses (FV) are complex retroviruses which are widespread in many species. Despite being discovered over 40 years ago, FV are among the least well characterized retroviruses. The replication of these viruses is different in many interesting respects from that of all other retroviruses. Infection of natural hosts by FV leads to a lifelong persistent infection, without any evidence of pathology. A large number of studies have looked at the prevalence of primate foamy viruses in the human population. Many of these studies have suggested that FV infections are prevalent in some human populations and are associated with specific diseases. More recent data, using more rigorous criteria for the presence of viruses, have not confirmed these studies. Thus, while FV are ubiquitous in all nonhuman primates, they are only acquired as rare zoonotic infections in humans. In this communication, we briefly discuss the current status of FV research and review the history of FV epidemiology, as well as the lack of pathogenicity in natural, experimental, and zoonotic infections

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Section: Other Diseasesmentioning

confidence: 99%

Historical Perspective of Foamy Virus Epidemiology and Infection

2001

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“…INTRODUCTION Sudden sensorineuralhearing loss, so-called sudden deafness, is an abrupt loss ofhearlng that occurs instantaneously or is present on awakening; hearing impairmentoccurswithina fewhoursof initialsymptoms.1-4Patientsmayor may not experiencetinnitus, vertigo,nausea,and/orvomiting.Hearingloss recurs in up to 50% of cases over time. 4 It is certain that there is no single cause of sudden deafness; the symptom of decreased hearing is the flnal outcome for many potential insults to the inner ear.The 3 most commonly accepted causes areviral infections, circulatory disorders, and labyrinthine membrane rupture. I .3.5,6 Increases in specific antibody titers found in some patients with sudden deafnesssuggesta viralcause.…”

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confidence: 99%

Sudden Sensorineural Hearing Loss Associated with Slow Blood Flow of the Vertebrobasilar System

Yamasoba¹,

Kikuchi²,

Higo³

et al. 1993

Ann Otol Rhinol Laryngol

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To determine the characteristics of sudden deafness associated with slow blood flow (SBF) within the vertebrobasilar arteries, we evaluated 57 patients with sudden deafness using magnetic resonance imaging (MRI). We detected SBF in 12 (21%) patients, predominantly men over 50 years of age. A second MRI performed in 5 patients 2 months after the onset of symptoms showed recovery of blood flow. All 12 patients complained of vertigo. Audiological and neurotologic tests suggested that hearing loss mainly involved the inner ear. Our findings suggest that unless central lesions are detected, headache, hypoesthesia of the external ear canal, and electronystagmographic abnormalities are signs of SBF. Because sudden deafness may recur in patients who have SBF, they should be monitored and treated to prevent recurrence.

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“…Controls were negative for all viruses tested. In addition, in the early 1990s, Pyykko et al [28] reported the significance of human spumaretrovirus in the pathogenesis of SSHL but since then no other studies have published similar results.…”

Section: Discussionmentioning

confidence: 68%

Sudden Sensorineural Hearing Loss: Subclinical Viral and Toxoplasmosis Infections as Aetiology and How They Alter the Clinical Course

Kikidis

Nikolopoulos²,

Kampessis³

et al. 2011

ORL

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Aim: To explore in a prospective study the evidence of certain viral and toxoplasmosis infections in sudden sensorineural hearing loss (SSHL). Methods: 84 consecutive patients with SSHL meeting certain criteria. All patients were assessed for specific IgM antibodies against cytomegalovirus, herpes simplex virus, toxoplasma and Epstein-Barr virus. All were treated with intravenous steroids and assigned to two groups: 76 IgM negative (NV group) and 8 IgM positive (no history of acute infection – V group). Results: The mean hearing level at presentation was 86.5 dB HL (median, 100) in the V group and 60.7 dB HL (median, 61) in the NV group. The difference was statistically significant (p = 0.003). The mean hearing level following treatment was 81.8 dB HL (median, 88) in the V group and 48.7 dB HL (median, 39) in the NV group. The difference was statistically significant (p = 0.004). There was a considerable improvement in hearing after treatment only in the NV group (p < 0.000001). Conclusions: Recent subclinical viral or toxoplasmosis infections may be involved in the pathogenesis of SSHL (in approx. 10% of cases), suggesting that SSHL is not a single disease. When certain viruses or toxoplasmoses are involved, the hearing is much worse in comparison to patients with no such indication of infection. An alteration in treatment dosage or method of steroid administration may be needed in such cases.

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Human Spumaretrovirus in the Etiology of Sudden Hearing Loss

Cited by 17 publications

References 12 publications

Historical Perspective of Foamy Virus Epidemiology and Infection

Historical Perspective of Foamy Virus Epidemiology and Infection

Sudden Sensorineural Hearing Loss Associated with Slow Blood Flow of the Vertebrobasilar System

Sudden Sensorineural Hearing Loss: Subclinical Viral and Toxoplasmosis Infections as Aetiology and How They Alter the Clinical Course

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