Human spot 14 protein interacts physically and functionally with the thyroid receptor

Chou, Wei-Yuan; Cheng, Yi‐Chiao; Ho, Ching‐Liang; Liu, Shuting; Liu, Pei-Yao; Kuo, Chao‐Yin; Chang, Hui-Ping; Chen, Yu-Hou; Chang, Gu-Gang; Huang, Shih‐Ming

doi:10.1016/j.bbrc.2007.03.103

Cited by 35 publications

(27 citation statements)

References 29 publications

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“…It is thought that Thrsp may regulate the expressions of genes related to fatty acid synthesis in liver and adipose tissues because the expression of Thrsp in these tissues is closely associated with fatty acid synthesis and carbohydrate inflow (22). Several recent studies have revealed that THRSP acts as a coactivator by interacting with nuclear transcriptional factors such as thyroid hormone receptor (23,24), chicken ovalbumin upstream promoter-transcription factor 1 (COUP-TF1) (25) and the p53 coactivator ZAC1 (24). Another study supports the notion that THRSP acts an activator of transcription because it promoted cell growth in breast cancer cell lines (26).…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Changes in the Jejunum of Rats during the Transient Suckling-Weaning Period

Mochizuki

Yorita

Goda

2009

J Nutr Sci Vitaminol

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SummaryIt is well-known that the small intestine of rodents rapidly undergoes differentiation and maturation during the transient suckling-weaning period from postnatal days 13 to 27. In the present study, we examined the gene expression changes in the jejunum of rats during the transient suckling-weaning period by microarray analysis. In the microarray data, we found that the expressions of many genes related to digestion/absorption/ excretion of nutrients/ions, such as members of the solute carrier ( Slc ) family and ATP-binding cassette ( Abc ) subfamily, were rapidly induced during this period. Furthermore, some transcriptional factors/cofactors ( Thrsp , Ppargc1a , Klf15 and Vdr ), which are presumably important for the induction of intestinal gene expression after weaning, were rapidly induced during this period. In contrast, genes related to transport of nutrients, such as folate, zinc, fat and phosphate, which are important for early development, were highly expressed in the suckling period and then gradually decreased during weaning. These results indicate that the jejunum matures during the suckling-weaning period accompanied by changes in the expression of many genes related to digestion/absorption/excretion and some genes for transcriptional factors/cofactors. Key Words transient suckling-weaning period, jejunum, solute carrier family, ATP-binding cassette subfamily, transcriptional factors/cofactorsThe morphology of the small intestine in rodents changes dramatically during the first 2-3 wk after birth as they are gradually weaned. During this period, the diet composition changes from one with less carbohydrate (milk) to one rich in carbohydrate (solid food) ( 1 ). Several studies have already shown that the expressions of genes related to carbohydrate digestion/absorption, such as disaccharidases [sucrase-isomaltase ( Si ) and trehalase ( Treh )], which are involved in the digestion of starch/sucrose or trehalose into monosaccharides, and hexose transporters [SGLT1 ( Slc5a1 ), GLUT5 ( Slc2a5 ) and GLUT2 ( Slc2a2 )], which are involved in monosaccharide absorption from the lumen, are elevated between 2 and 3 wk after birth in rodents ( 2 -5 ). In addition, we previously reported that the gene expressions of liver-type fatty acid-binding protein [L-FABP ( Fabp1 )] and cellular retinol-binding protein type II [CRBPII ( Rbp2 )], which are involved in transporting fatty acids and vitamin A, respectively, from the lumen to enterocytes, as well as a ␤ -oxidation rate-controlling gene [acyl-CoA oxidase ( Acox1 )], were highly expressed in the transient suckling-weaning period, and declined after weaning ( 6 , 7 ). Furthermore, the gene expression of peroxisome proliferator-activated receptor ␣ [PPAR ␣ ( Ppara )], a transcriptional factor for these genes, was associated with these gene expression changes ( 6 ).These changes during the transient suckling-weaning period may be regulated by the nutritional changes as well as hormones, such as thyroid hormone and glucocorticoid hormone, because such hormones ar...

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Section: Discussionmentioning

confidence: 99%

Gene Expression Changes in the Jejunum of Rats during the Transient Suckling-Weaning Period

Mochizuki

Yorita

Goda

2009

J Nutr Sci Vitaminol

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“…Furthermore, we established that the expression of S14 in the bovine mammary gland is down-regulated in both CLA-and diet-induced MFD . Although its exact biochemical function is not known, S14 is found in the nucleus and is a putative transcriptional coactivator (Cunningham et al, 1998;Chou et al, 2007 and that is highly responsive to pro-lipogenic signals including SREBP1 activation (Martel et al, 2006). The expression of S14 is positively associated with conditions of excessive lipid synthesis, including human obesity, chicken lines selected for increased growth and adiposity, muscle of cattle selected for marbling and high lipogenic cancers (summarized in .…”

Section: Sterol Response Element-binding Protein-1mentioning

confidence: 99%

Recent advances in the regulation of milk fat synthesis

Harvatine

Boisclair

Bauman

2009

Animal

264

272

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In addition to its economic value, milk fat is responsible for many of milk's characteristics and can be markedly affected by diet. Diet-induced milk fat depression (MFD) was first described over a century ago and remains a common problem observed under both intensive and extensive management. The biohydrogenation theory established that MFD is caused by an inhibition of mammary synthesis of milk fat by specific fatty acids (FA) produced as intermediates in ruminal biohydrogenation. During MFD, lipogenic capacity and transcription of key lipid synthesis genes in the mammary gland are down-regulated in a coordinated manner. Our investigations have established that expressions of sterol response element-binding protein 1 (SREBP1) and SREBP-activation proteins are down-regulated during MFD. Importantly, key lipogenic enzymes are transcriptionally regulated via SREBP1. Collectively, these results provide strong evidence for SREBP1 as a central signaling pathway in the regulation of mammary FA synthesis. Spot 14 is also down-regulated during MFD, consistent with a lipogenic role for this novel nuclear protein. In addition, SREBP1c and Spot 14 knock-out mice exhibit reduced milk fat similar to the magnitude and pattern of MFD in the cow. Application of molecular biology approaches has provided the latest chapter in the regulation of milk fat synthesis and is reviewed along with a brief background in nutritional regulation of milk fat synthesis in ruminants.

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“…However, mice models of TRa signalling disruption have revealed the contribution of this TR isoform to thyroid hormone effects on lipid metabolism (Liu et al 2007, Jornayvaz et al 2012. The TRaPV knock-in mouse and the TRa knockout mice showed reduction of lipogenic gene expression in the liver (Araki et al 2009, Jornayvaz et al 2012, contrary to TRb1PV knock-in mouse (Araki et al 2009), suggesting the distinct regulation by both isoforms on hepatic lipid metabolism and the TRa involvement in hepatic lipogenesis (Fig.…”

Section: Thyroid Hormone Effects On Lipid Metabolismmentioning

confidence: 96%

“…Besides the direct effect in the transcription of these enzymes, thyroid hormones promote a rapid and important increase in Spot14 (S14 (THRSP)) expression, a protein which is able to interact physically and functionally with the thyroid hormone receptor (TR) to regulate malic enzyme gene expression (Chou et al 2007). The elevated S14 expression is important to increase lipogenic enzyme expressions induced by T 3 (Cunningham et al 1998).…”

Section: Thyroid Hormone Effects On Lipid Metabolismmentioning

confidence: 99%

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Non-classic thyroid hormone signalling involved in hepatic lipid metabolism

Cordeiro

Souza

Einicker‐Lamas

et al. 2013

Journal of Endocrinology

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Thyroid hormones are important modulators of lipid metabolism because the liver is a primary hormonal target. The hypolipidaemic effects of thyroid hormones result from the balance between direct and indirect actions resulting in stimulation of lipid synthesis and lipid oxidation, which favours degradation pathways. Originally, it was believed that thyroid hormone activity was only transduced by alteration of gene transcription mediated by the nuclear receptor thyroid hormone receptors, comprising the classic action of thyroid hormone. However, the discovery of other effects independent of this classic mechanism characterised a new model of thyroid hormone action, the non-classic mechanism that involves other signalling pathways. To date, this mechanism and its relevance have been intensively described. Considering the increasing evidence for non-classic signalling of thyroid hormones and the major influence of these hormones in the regulation of lipid metabolism, we reviewed the role of thyroid hormone in cytosolic signalling cascades, focusing on the regulation of second messengers, and the activity of effector proteins and the implication of these mechanisms on the control of hepatic lipid metabolism.

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Human spot 14 protein interacts physically and functionally with the thyroid receptor

Cited by 35 publications

References 29 publications

Gene Expression Changes in the Jejunum of Rats during the Transient Suckling-Weaning Period

Gene Expression Changes in the Jejunum of Rats during the Transient Suckling-Weaning Period

Recent advances in the regulation of milk fat synthesis

Non-classic thyroid hormone signalling involved in hepatic lipid metabolism

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