Human spinal interneurons repair the injured spinal cord through synaptic integration
Lyandysha V. Zholudeva,
Tara Fortino,
Ayushi Agrawal
et al.
Abstract:Advances in cell therapy offer promise for some of the most devastating neural injuries, including spinal cord injury (SCI). Endogenous VSX2-expressing spinal V2a interneurons have been implicated as a key component in plasticity and therapeutically driven recovery post-SCI. While transplantation of generic V2a neurons may have therapeutic value, generation of human spinal V2a neurons with rostro-caudal specificity and assessment of their functional synaptic integration with the injured spinal cord has been el… Show more
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