Human skin allograft: Is it a viable option in management of burn patients?

Gupta, Saurabh; Mohapatra, Devi Prasad; Chittoria, Ravi Kumar; Subbarayan, Elankumar; Reddy, Sireesha K; Chavan, Vinayak; Aggarwal, Abhinav; Reddy, Likhitha C

doi:10.4103/jcas.jcas_83_18

Cited by 16 publications

(4 citation statements)

References 7 publications

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“…The most significant disadvantage is rejection due to the immunogenic structures. Another significant disadvantage is the risk of transport of some infections from the donor to the recipient (17). While many studies have been conducted with different scaffold samples in many centers, most scaffold structures studied are synthetic biomaterials, and some are allogeneic cadaveric.…”

Section: Discussionmentioning

confidence: 99%

Toxicological Analysis of a New Fibrin-Derived Dermal Scaffold (Dermoturk); Acellular and Combined with Stem Cells Forms

ŞENEL,

DEMİR,

GÖKCE

et al. 2024

Türkiye Çocuk Hast Derg

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Objective: We aimed to reveal the toxicological analysis of the newly developed fibrin-derived scaffold forms (DermoTurk) before human studies. Material and Methods: 42 male Albino Wistar rats were used. Two of them were used to produce mesenchymal and epidermal stem cells. Forty rats were divided into five groups, each consisting of 8 rats; the acellular scaffold applied group as Group-1, the mesenchymal stem cells added scaffold used group as Group-2, the MSCs and epidermal stem cells-added scaffold applied group as Group-3, MSCs- and epidermal stem cells-added scaffold applied outbred group as Group-4 and control as Group-5. The changing of laboratory tests in the groups was evaluated five days before application and on the 7th and 40th days. After the autopsy performed on the 40th day of the study, rats’ organs and scaffold implanted skin area were evaluated histologically. All the results of the groups were compared. SPSS 22.0 was used for analyses. P <0.05 was accepted as statistically significant. Results: There were no differences between the groups in terms of laboratory results. Histologically, a mild-grade foreign body reaction against the DermoTurk was found in all groups; this reaction was less in groups 3 and 4 with the richest stem cells. Conclusion: This study revealed that DermoTurk is safe in rats. It could be an important alternative to skin substitutes, with stem cells or alone. Human studies for clinical efficacy should be carried out.

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Section: Discussionmentioning

confidence: 99%

Toxicological Analysis of a New Fibrin-Derived Dermal Scaffold (Dermoturk); Acellular and Combined with Stem Cells Forms

ŞENEL,

DEMİR,

GÖKCE

et al. 2024

Türkiye Çocuk Hast Derg

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“…10,11 The use of skin substitutes in the treatment of pediatric burn wounds is a viable alternative to allografts, as they are effective in promoting wound healing and reducing infection risk while avoiding the problems typically associated with allografts, including cost. 12 The use of ADM eliminates donor-site morbidity, which is helpful in pediatric patients, who require conservation of body surface area. By using quickly incorporating ADM, such as Kerecis, we have been able to quickly rehabilitate patients, obviating the need for autologous grafting and minimizing the risk of contracture.…”

Section: Discussionmentioning

confidence: 99%

Acellular Piscine Dermis for Pediatric Hand Burn Reconstruction

Shahriari,

Harrison,

Clarke

et al. 2024

Plastic and Reconstructive Surgery - Global Open

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Summary: Pediatric hand burns are difficult to treat, with thin tissue with critical structures close to the skin and the small scale of the anatomy of children’s hands. Additionally, pediatric burns can be challenging due to the concern for donor-site morbidity and the paucity of donor sites when reconstructing these wounds. In this report, we discuss the successful application of a piscine-derived acellular dermal matrix in a 13-month-old child with deep partial thickness and full-thickness burns to the right upper extremity. She had excellent long term cosmetic results and function by 3 years postoperatively, including full extension and flexion of all digits in her right hand.

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“…Regenerative medicine is an emerging field that allows to overcome many limits placed so far in the management and treatment of several diseases [10,11]. In fact, when tissue damage occurs, the standard therapeutical options are limited: materials availability for autologous transplantation is scarce, and the same sampling can create further complications for the patient, while allograft has a high risk of immunogenicity [12]. In particular, thanks to the huge developments of tissue engineering, it is now possible to replace devitalized tissues and organs with functional insufficiency, as well as to transport therapeutic substances and cells in the target area.…”

Section: Regenerative Medicine Applicationsmentioning

confidence: 99%

Hydrogel-Based Delivery for Antineoplastic Drugs and Vascular Scaffolding

Iervolino¹,

Chello²,

Chello³

et al. 2021

Preprint

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Hydrogels, hydrophilic polymeric compounds, have been recently put under investigation as regenerative medicine applications and delivery systems for antineoplastic drugs, particularly chemotherapeutics (anthracyclines, alkylating agents), target drugs (trastuzumab) and immunotherapies. Porosity, conductivity, biodegradability and physical states are some of the peculiarities that render hydrogels suitable for therapies implementation. Chemically-modifying agents and enzymes can be also coupled to hydrogels for pharmacokinetical parameters improvement and side effects avoidance. Cardiotoxicity is in fact one of the major issues for oncological patients after treatment efficacy. Heart failure, myocarditis and hypertension are causes of morbidity and mortality that can possibly be avoided. Specific reaching of the target tumor site has been achieved by several authors in preclinical in vivo studies but clinical studies are currently under design processes. Polydioxanone, a hydrogel-mimicking agent, is capable to interact with the elastic properties of pulmonary artery. An advantageous characteristic is that can be also reabsorbed within biological systems and can cause a remodeling process of the vessel wall. Hydrogels currently represent a strong topic of interest for researchers and probably will guide future clinical investigations and practice.

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Human skin allograft: Is it a viable option in management of burn patients?

Cited by 16 publications

References 7 publications

Toxicological Analysis of a New Fibrin-Derived Dermal Scaffold (Dermoturk); Acellular and Combined with Stem Cells Forms

Toxicological Analysis of a New Fibrin-Derived Dermal Scaffold (Dermoturk); Acellular and Combined with Stem Cells Forms

Acellular Piscine Dermis for Pediatric Hand Burn Reconstruction

Hydrogel-Based Delivery for Antineoplastic Drugs and Vascular Scaffolding

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