Human skeletal muscle behavior in vivo: Finite element implementation, experiment, and passive mechanical characterization

Clemen, Christof B.; Benderoth, G.; Schmidt, Andreas B.; Hübner, Frank; Vogl, Thomas J.; Silber, Gerhard

doi:10.1016/j.jmbbm.2016.09.030

Cited by 9 publications

(10 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the complexity in model formulation and evaluation, active muscle modeling has been commonly performed for a large range of muscles including generic muscle tissue [36, 37, 43, 54], brachialis [35], rectus femoris [38, 46], levator ani [40], biceps brachii [23, 39, 55], gastrocnemius [41, 42, 53], tibialis anterior [44, 47, 49–51], biceps femoris longhead [45], soleus [46, 53], ventral interior lateral muscle [48], lumbar spine muscles [52], and facial muscles [22, 26, 56–59]. Geometrical models of skeletal muscles have been reconstructed from medical imaging (CT and MRI) [22, 23, 26, 38, 45, 50, 53–59].…”

Section: Continuum Models Of Skeletal Musclesmentioning

confidence: 99%

“…Several approaches have been proposed. Parallel fiber distribution in a single direction [22, 37, 39, 41, 42, 44, 46, 48, 51, 54, 55, 59] or at a specific pennation angle [23, 43, 49] has been commonly performed. Bipennate fiber orientation has been also proposed [38].…”

Section: Continuum Models Of Skeletal Musclesmentioning

confidence: 99%

“…Current simulations of active skeletal muscles relate to basic loading scenarios. Isometric activation has been simulated in some studies [36, 50, 51, 55]. Shortening and lengthening have been studied [35, 39, 43, 45, 47, 48, 51].…”

Section: Continuum Models Of Skeletal Musclesmentioning

confidence: 99%

“…Mathematical modeling of biological tissues and systems is meaningful only when the model outcome is quantitatively validated in a systematic way. Most of the developed active skeletal muscle models have been validated against literature data [36, 37, 43, 49, 50, 57] or measured data in in vivo conditions [22, 26, 39, 41, 42, 44, 47, 53–55, 58, 59]. However, there are still some proposed models without validation efforts [23, 35, 38, 45, 46, 48, 56].…”

Section: Continuum Models Of Skeletal Musclesmentioning

confidence: 99%

See 3 more Smart Citations

A Systematic Review of Continuum Modeling of Skeletal Muscles: Current Trends, Limitations, and Recommendations

Dao

Tho

2018

Applied Bionics and Biomechanics

View full text Add to dashboard Cite

Finite elasticity theory has been commonly used to model skeletal muscle. A very large range of heterogeneous constitutive laws has been proposed. In this review, the most widely used continuum models of skeletal muscles were synthetized and discussed. Trends and limitations of these laws were highlighted to propose new recommendations for future researches. A systematic review process was performed using two reliable search engines as PubMed and ScienceDirect. 40 representative studies (13 passive muscle materials and 27 active muscle materials) were included into this review. Note that exclusion criteria include tendon models, analytical models, 1D geometrical models, supplement papers, and indexed conference papers. Trends of current skeletal muscle modeling relate to 3D accurate muscle representation, parameter identification in passive muscle modeling, and the integration of coupled biophysical phenomena. Parameter identification for active materials, assumed fiber distribution, data assumption, and model validation are current drawbacks. New recommendations deal with the incorporation of multimodal data derived from medical imaging, the integration of more biophysical phenomena, and model reproducibility. Accounting for data uncertainty in skeletal muscle modeling will be also a challenging issue. This review provides, for the first time, a holistic view of current continuum models of skeletal muscles to identify potential gaps of current models according to the physiology of skeletal muscle. This opens new avenues for improving skeletal muscle modeling in the framework of in silico medicine.

show abstract

Section: Continuum Models Of Skeletal Musclesmentioning

confidence: 99%

Section: Continuum Models Of Skeletal Musclesmentioning

confidence: 99%

Section: Continuum Models Of Skeletal Musclesmentioning

confidence: 99%

Section: Continuum Models Of Skeletal Musclesmentioning

confidence: 99%

See 2 more Smart Citations

A Systematic Review of Continuum Modeling of Skeletal Muscles: Current Trends, Limitations, and Recommendations

Dao

Tho

2018

Applied Bionics and Biomechanics

View full text Add to dashboard Cite

show abstract

“…For the current model, the assumption was made that the excitable constituent did not contain a fluid component, and as such the constitutive approaches for the excitable and passive constituents are very similar, with the only exception being that the excitable constituent did not include a permeability/poroelasticity. Thus, it is assumed that the excitable tissue is comprised of solid material only as a compressible hyperviscoelastic material [17][18][19][20], while passive tissue was modeled as compressible hypervisco-poroelastic material [21].…”

Section: Constitutive Modelmentioning

confidence: 99%

Modeling Skeletal Muscle Stress and Intramuscular Pressure: A Whole Muscle Active–Passive Approach

Wheatley

Odegard

Kaufman

et al. 2018

Journal of Biomechanical Engineering

View full text Add to dashboard Cite

Clinical treatments of skeletal muscle weakness are hindered by a lack of an approach to evaluate individual muscle force. Intramuscular pressure (IMP) has shown a correlation to muscle force in vivo, but patient to patient and muscle to muscle variability results in difficulty of utilizing IMP to estimate muscle force. The goal of this work was to develop a finite element model of whole skeletal muscle that can predict IMP under passive and active conditions to further investigate the mechanisms of IMP variability. A previously validated hypervisco-poroelastic constitutive approach was modified to incorporate muscle activation through an inhomogeneous geometry. Model parameters were optimized to fit model stress to experimental data, and the resulting model fluid pressurization data were utilized for validation. Model fitting was excellent (root-mean-square error or RMSE <1.5 kPa for passive and active conditions), and IMP predictive capability was strong for both passive (RMSE 3.5 mmHg) and active (RMSE 10 mmHg at in vivo lengths) conditions. Additionally, model fluid pressure was affected by length under isometric conditions, as increases in stretch yielded decreases in fluid pressurization following a contraction, resulting from counteracting Poisson effects. Model pressure also varied spatially, with the highest gradients located near aponeuroses. These findings may explain variability of in vivo IMP measurements in the clinic, and thus help reduce this variability in future studies. Further development of this model to include isotonic contractions and muscle weakness would greatly benefit this work.

show abstract

Design and Simulation of a Novel Pneumotronic System Aimed to the Investigation of Vascular Phenomena Induced by Limb Compression

et al. 2019

View full text Add to dashboard Cite

Intermittent Pneumatic Compression (IPC) devices can be used to analyze the mechanisms underlying several vascular phenomena, such as hyperaemia. Commercial devices have limited dynamics and do not allow the delivery of customizable compressive pressure patterns, making difficult the analysis of such phenomena, which may require the application of long stimulations with low amplitude as well as fast compressions with higher pressure level. To overcome these issues, a novel pneumo-tronic device aimed to the investigation of the physiological effects induced by limb compressions has been conceived and is presented in this work. The design requirements of the system, capable of delivering customizable compressive patterns in the range 0-200 mmHg, are outlined. The final prototype architecture is described, and a mathematical model of the entire system, also including the interaction between the device and the limb tissues, is proposed. The performance of the device has been evaluated in several conditions by means of simulations, whose results have been compared to the data collected from experimental trials in order to validate the model. The outcomes of both experimentation and simulation trials proved the effectiveness of the solution proposed. A possible employment of this device for the investigation of the rapid compression-induced hyperaemia is presented. Other potential applications concern the wide range of intermittent-pneumatic compression treatments.

show abstract

Human skeletal muscle behavior in vivo: Finite element implementation, experiment, and passive mechanical characterization

Cited by 9 publications

References 43 publications

A Systematic Review of Continuum Modeling of Skeletal Muscles: Current Trends, Limitations, and Recommendations

A Systematic Review of Continuum Modeling of Skeletal Muscles: Current Trends, Limitations, and Recommendations

Modeling Skeletal Muscle Stress and Intramuscular Pressure: A Whole Muscle Active–Passive Approach

Design and Simulation of a Novel Pneumotronic System Aimed to the Investigation of Vascular Phenomena Induced by Limb Compression

Contact Info

Product

Resources

About