Human serum albumin: Possible cause of insulin autoimmune syndrome

Kamei, Shinji; Kaneto, Hideaki; Shigemoto, Ryo; Ejiri, Sumiko; Tanabe, Akihito; Tatsumi, Fuminori; Kimura, Tomohiko; Obata, Atsushi; Shimoda, Masashi; Tawaramoto, Kazuhito; Kohara, Kenji; Anno, Takatoshi; Kawasaki, Fumiko; Mune, Tomoatsu; Kaku, Kohei

doi:10.1111/jdi.12515

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…Another widely-used compound is albumin. It has recently been demonstrated that albumin has a cysteine residue (Cys34) with a strong reducing capacity, like ALA. Kamei et al described a case of IAS occurring in a patient who was taking no drugs containing a sulfhydryl group, but who was taking albumin (29). Loxoprofen-sodium is capable of inducing IAS even when administered through adhesive skin patches (30).…”

Section: Trigger Factors and Diseases Associated With Iasmentioning

confidence: 99%

Insulin autoimmune syndrome: from diagnosis to clinical management

2018

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Autoimmune forms of hypoglycemia are a rare cause of low blood sugar levels among Caucasians, and often go misdiagnosed, exposing patients to lengthy series of pointless, potentially harmful and expensive tests. There are two types of autoimmune hypoglycemia. One is insulin autoimmune syndrome (IAS), which is characterized by hyperinsulinemic hypoglycemia, elevated insulin autoantibody (IAA) titers, no prior exposure to exogenous insulin, and no of pathological abnormalities of the pancreatic islets. This condition is also known as "Hirata's disease". The other is type B insulin resistance syndrome (TBIRS), a rare autoimmune disorder resulting in a broad array of abnormalities in glucose homeostasisfrom hypoglycemia to extremely insulin-resistant hyperglycemia-caused by the presence of insulin receptor autoantibodies (IRAbs). This review focuses on these two syndromes, describing their epidemiology, possible genetic background, clinical presentation, pathophysiology, diagnosis and treatment.

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Section: Trigger Factors and Diseases Associated With Iasmentioning

confidence: 99%

Insulin autoimmune syndrome: from diagnosis to clinical management

2018

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“…Te most common such drugs are methimazole [16,17] and lipoic acid [18][19][20][21][22]. Others include clopidogrel [23][24][25][26], proton pump inhibitors [27] (pantoprazole [8], omeprazole), carbimazole [28], coenzyme Q10 [29], antituberculosis drugs [30], gliclazide [31], captopril [32], loxoprofen sodium [33], and albumin preparations [34], within the preceding week. Studies have shown that approximately half of IAS patients have a history of medication before the onset of the disease, and more than 90% of them used drugs containing sulfhydryl groups such as α-lipoic acid or its metabolites [35].…”

Section: Classifcation Of Iasmentioning

confidence: 99%

Insulin Autoimmune Syndrome: A Systematic Review

Lin

Chen

Ning

2023

International Journal of Endocrinology

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Insulin autoimmune syndrome (IAS) is a rare endocrine disorder characterized by recurrent episodes of severe hypoglycemia, markedly elevated serum insulin, and positive insulin autoantibodies. In recent years, various countries have reported it one after another. It can be seen that we must pay attention to this disease. The diagnosis of IAS is challenging, requiring a careful workup aimed at excluding other causes of hyperinsulinemic hypoglycemia. High levels of insulin autoantibodies are found in patients, and C-peptide is not parallel to insulin, which could be diagnostic. IAS is a self-limiting disease with a good prognosis. Its treatment mainly includes symptomatic supportive treatment, such as adjusting the diet and using acarbose and other drugs to delay the absorption of glucose to prevent hypoglycemia. For patients with severe symptoms, available treatments may include drugs that reduce pancreatic insulin secretion (such as somatostatin and diazoxide), immunosuppressants (glucocorticoids, zaprin, and rituximab), and even plasma exchange to remove autoantibodies from the body. This review provides a comprehensive analysis of the epidemiology, pathogenesis, clinical manifestations, diagnosis and identification, and monitoring and treatment management of IAS.

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Albumin human

2017

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Human serum albumin: Possible cause of insulin autoimmune syndrome

Cited by 4 publications

References 4 publications

Insulin autoimmune syndrome: from diagnosis to clinical management

Insulin autoimmune syndrome: from diagnosis to clinical management

Insulin Autoimmune Syndrome: A Systematic Review

Albumin human

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