Human serum albumin as the carrier to fabricate STING-activating peptide nanovaccine for antitumor immunotherapy

Zheng, Aixian; Ning, Zhaoyu; Wang, Xiaorong; Li, Zhenli; Sun, Yupeng; Wu, Ming; Zhang, Da; Liu, Xiaolong; Chen, Jianwu; Zeng, Yongyi

doi:10.1016/j.mtbio.2024.100955

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…Utilizing the mechanism of activating the STING pathway similarly, Zheng et al developed albumin NPs carrying STING-activating peptide, termed HSA-MnO 2 -pep. 149 They employed an oxidation–reduction reaction between HSA and potassium permanganate (KMnO 4 ) to synthesize biodegradable manganese dioxide for vaccine design. Manganese dioxide (MnO 2 ) degraded into manganese ions within cells, triggering the activation of the STING pathway, which promotes DC maturation and antigen presentation (Fig.…”

Section: Immunotherapy For Cancermentioning

confidence: 99%

The recent advancements in protein nanoparticles for immunotherapy

Xu,

Wei,

Duan

et al. 2024

Nanoscale

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Section: Immunotherapy For Cancermentioning

confidence: 99%

The recent advancements in protein nanoparticles for immunotherapy

Xu,

Wei,

Duan

et al. 2024

Nanoscale

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“…Biomimicry achieves this and helps the body when exposed to actual threats [11][12][13]. In addition, nanomaterials can absorb antigens and adjuvants, protecting them from decomposition and enabling them to be released in a controlled manner; this enhances immunogenicity while minimizing side effects [14,15]. Nanovaccines can enable tumor vaccination using needle-free delivery methods such as nasal sprays and oral vaccines, which is a significant advancement [16].…”

Section: Introductionmentioning

confidence: 99%

The Intellectual Landscape of Nanovaccines: A Bibliometric Perspective on Scientific Progress and Future Directions

Jose,

M N,

R G

et al. 2024

Cureus

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This bibliometric study provides a comprehensive analysis of the burgeoning field of nanovaccine research, leveraging data sourced from Scopus and employing the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) flowchart for the meticulous screening, inclusion, and exclusion of relevant studies. Utilizing sophisticated bibliometric tools, such as Biblioshiny and CiteSpace, we dissected the expansive literature to unearth critical insights into the annual scientific output, identifying key contributors and pivotal publications that have shaped the domain. The analysis delineates the most influential authors, sources, and globally cited documents, offering a macroscopic view of the field's intellectual structure and growth trajectory. Trend topics and thematic mapping underscored the evolution of research foci, from fundamental immunological mechanisms to cutting-edge nanomaterial applications. Factorial analysis and keyword co-occurrence networks revealed the intricate associations and thematic concentrations within the literature. The study's robust methodology also pinpointed the keywords exhibiting the strongest citation bursts, signifying emergent areas of intense academic interest. Networks of cited authors illuminated collaborative patterns among scholars, while timeline network visualizations of country collaborations depicted the global interplay in nanovaccine development. Crucially, this study identified notable research gaps and practical implications, suggesting directions for future investigation and highlighting the translational potential of nanovaccines in public health and personalized medicine. This bibliometric investigation not only maps the current landscape but also charts a course for the trajectory of nanovaccine research, emphasizing its role as a cornerstone of innovative immunotherapeutic strategies.

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Research progress of serum albumin in the field of drug delivery

Ji,

Zheng,

et al. 2024

Interdisciplinary Medicine

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As a drug delivery system with wide application potential, serum albumin drug‐carrying nanoparticles have attracted extensive attention in the field of drug delivery in recent years. This review aims to summarize the research progress of serum albumin drug‐loaded nanoparticles in the field of drug delivery. Firstly, the excellent properties of serum albumin as a drug carrier were introduced, several methods of preparing serum albumin nanoparticles were discussed in depth, and their advantages and disadvantages were compared. Then, the design of the nanoparticle albumin drug carrier is discussed, including the control of the size of the nanoparticle, the surface properties and the amount of drug loading, so as to achieve better drug delivery effect. Finally, a series of therapeutic approaches using serum albumin nanoparticles as drug carriers, such as anti‐cancer drug delivery and drug delivery across the blood‐brain barrier, are systematically summarized. In summary, the research of serum albumin drug‐carrying nanoparticles has brought new possibilities and opportunities to the field of drug delivery, and inspired more innovative research and practical applications.

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Human serum albumin as the carrier to fabricate STING-activating peptide nanovaccine for antitumor immunotherapy

Cited by 5 publications

References 35 publications

The recent advancements in protein nanoparticles for immunotherapy

The recent advancements in protein nanoparticles for immunotherapy

The Intellectual Landscape of Nanovaccines: A Bibliometric Perspective on Scientific Progress and Future Directions

Research progress of serum albumin in the field of drug delivery

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