Human Serum Albumin as Multifunctional Nanocarrier for Cancer Therapy

Zeeshan, Farrukh; Madheswaran, Thiagarajan; Panneerselvam, Jithendra; Taliyan, Rajeev; Kesharwani, Prashant

doi:10.1016/j.xphs.2021.05.001

Cited by 36 publications

(24 citation statements)

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“…Indeed, HSA represents the carrier for fatty acids, heme, nucleic acids, cholesterol, nitric oxide, bile pigments, hormones, and metals ions (ex. calcium (II), zinc (II), nickel (II)), and renders potential toxins harmless [44,50,51]. As one of the most abundant plasma proteins, not a single drug in the blood will pass without its «strength test».…”

Section: Role Of Albumin In Humansmentioning

confidence: 99%

“…It influences the stability, pharmacokinetics, biodistribution of drug-delivery systems by binding or forming its protein corona on the surface. Albumin has various (pseudo-)enzymatic properties such as esterase, RNA-hydrolyzing, enolase, lipid peroxidase, etc., activities [44,50,51]. These weak activities are essential considering the large amount of HSA in the body [43,52].…”

Section: Role Of Albumin In Humansmentioning

confidence: 99%

“…HSA is a three-domain allosteric macromolecule with molecular weight 66.5 kDa and half-life ~20 days responsible for plasma oncotic pressure and fluid distribution between body compartments [44,51]. HSA consists of 65-68% α-helices with some turns, extended loops, and little β-sheets content (~1-3%).…”

Section: Albumin Structurementioning

confidence: 99%

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Serum Albumin for Magnetic Nanoparticles Coating

Chubarov

2022

Magnetochemistry

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Magnetic nanoparticles (MNPs) have great potential in biochemistry and medical science. In particular, iron oxide nanoparticles have demonstrated a promising effect in various biomedical applications due to their high magnetic properties, large surface area, stability, and easy functionalization. However, colloidal stability, biocompatibility, and potential toxicity of MNPs in physiological environments are crucial for their in vivo application. In this context, many research articles focused on the possible procedures for MNPs coating to improve their physic-chemical and biological properties. This review highlights one viable fabrication strategy of biocompatible iron oxide nanoparticles using human serum albumin (HSA). HSA is mainly a transport protein with many functions in various fundamental processes. As it is one of the most abundant plasma proteins, not a single drug in the blood passes without its strength test. It influences the stability, pharmacokinetics, and biodistribution of different drug-delivery systems by binding or forming its protein corona on the surface. The development of albumin-based drug carriers is gaining increasing importance in the targeted delivery of cancer therapy. Considering this, HSA is a highly potential candidate for nanoparticles coating and theranostics area and can provide biocompatibility, prolonged blood circulation, and possibly resolve the drug-resistance cancer problem.

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Section: Role Of Albumin In Humansmentioning

confidence: 99%

Section: Role Of Albumin In Humansmentioning

confidence: 99%

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Serum Albumin for Magnetic Nanoparticles Coating

Chubarov

2022

Magnetochemistry

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“…Nanotechnology is an umbrella term defined as the scientific principles, process, methodologies, techniques, and other scientific activity dealing in the size range from a few nanometers to several hundred nm, depending upon their intended use ( Peer et al, 2007 ; Dubey et al, 2021 ; Srivastava et al, 2021 ; Kumar et al, 2021 ). Nanotechnology has become the focused area of interest over the last few decades for emerging drug delivery systems because it offers several unique advantages over the conventional drug delivery system ( Malam et al, 2009 ; Zeeshan et al, 2021 ). It is also a promising and intelligent approach for the theranosis of many dangerous diseases like cancer, as it is able to deliver its cargo directly to its target.…”

Section: Nanotechnology In Cancer Targetingmentioning

confidence: 99%

CD44-Targeted Nanocarrier for Cancer Therapy

et al. 2022

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Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in varieties of solid tumors including pancreatic, breast, ovary, brain, and lung cancers. It is a multi-structural glycoprotein of the cell surface which is majorly involved in cell proliferation, cell-to-cell interaction, cellular migration, inflammation, and generation of immune responses. Numerous studies focus on the development of nanocarriers for active targeting of the CD44 receptor to improve efficacy of targeting chemotherapy and achieve precise chemotherapy by defining the release, uptake, and accumulation of therapeutic agents. The CD44 receptor has a selective binding affinity towards hyaluronic and chondroitin sulfate (CS). Taking this into consideration, this review focused on the role of CD44 in cancer and its therapy using several nanocarriers such as polymeric/non-polymeric nanoparticles, dendrimer, micelles, carbon nanotubes, nanogels, nanoemulsions etc., for targeted delivery of several chemotherapeutic molecules and nucleic acid. This review also illuminates the role of hyaluronic acid (HA) in cancer therapy, interaction of HA with CD44, and various approaches to target CD44-overexpressed neoplastic cells.

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“…Human serum albumin is a flexible protein that is used to make albumin-based nanocarriers (ANCs) for the administration of cancer treatments [ 59 , 60 ]. Because of the various drug binding sites found in the albumin molecule, a large amount of drug can be integrated into the particle matrix with serum albumin nanoparticles [ 61 ].…”

Section: Protein-based Nanoparticlesmentioning

confidence: 99%