Human seminal virome: a panel based on recent literature

Albuquerque, Beatriz Helena Dantas Rodrigues de; Oliveira, Maryana Thalyta Ferreira Camara de; Aderaldo, Janaína Ferreira; Torres, Mychelle de Medeiros Garcia; Lanza, Daniel Carlos Ferreira

doi:10.1186/s12610-022-00165-9

Cited by 6 publications

(4 citation statements)

References 186 publications

(249 reference statements)

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“…Different species from the Herpesviridae family, like herpesvirus and cytomegalovirus (HCMV) [ 39 , 40 , 43 , 44 , 45 , 46 ], and from the Papillomaviridae family [ 43 , 44 , 45 , 47 , 48 ] are also frequent, as well as Parvoviridae like adeno-associated viruses (AAV) [ 40 , 44 ]. The human immunodeficiency virus (HIV) is one of the most cited virus regarding seminal microbiota [ 49 ]. Several studies have detected SARS-CoV-2 in semen after COVID-19 infection [ 50 , 51 ].…”

Section: Origin Of the Seminal Microbiome And General Compositionmentioning

confidence: 99%

“…Specifically, its potential role in fertility is becoming clear. It is known that infections and inflammatory reactions in the male genital tract are the cause of around 6–10% of infertility cases [ 49 ]. In fact, many studies have discovered that fertile and infertile populations displayed different bacterial cohorts in the seminal fluid.…”

Section: The Semen Microbiome In Fertility Disordersmentioning

confidence: 99%

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Unraveling the Intricacies of the Seminal Microbiome and Its Impact on Human Fertility

Corral-Vazquez,

Blanco,

Sarrate

et al. 2024

Biology

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Although the microbial communities from seminal fluid were an unexplored field some decades ago, their characteristics and potential roles are gradually coming to light. Therefore, a complex and specific microbiome population with commensal niches and fluctuating species has started to be revealed. In fact, certain clusters of bacteria have been associated with fertility and health, while the outgrowth of several species is potentially correlated with infertility indicators. This constitutes a compelling reason for outlining the external elements that may induce changes in the seminal microbiome composition, like lifestyle factors, gut microbiota, pathologies, prebiotics, and probiotics. In this review, we summarize the main findings about seminal microbiome, its origins and composition, its relationship with fertility, health, and influence factors, while reminding readers of the limitations and advantages introduced from technical variabilities during the experimental procedures.

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Section: Origin Of the Seminal Microbiome And General Compositionmentioning

confidence: 99%

Section: The Semen Microbiome In Fertility Disordersmentioning

confidence: 99%

Unraveling the Intricacies of the Seminal Microbiome and Its Impact on Human Fertility

Corral-Vazquez,

Blanco,

Sarrate

et al. 2024

Biology

View full text Add to dashboard Cite

show abstract

“…In the male reproductive tract, the infection damages spermatogonia and Sertoli cells, destroys testicular architecture, decreases sperm motility, and thus reduces fertility 76 . In parallel, in the female genital tract, viral RNA has been reported in the cervical mucosa up to 11 days after the onset of symptoms.…”

Section: Clinical Embryonic and Fetal Manifestations Of Czsmentioning

confidence: 99%

Congenital Zika syndrome

Crisanto-López¹,

Jesús²,

López-Quecho³

et al. 2023

BMHIM

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In February 2016, the World Health Organization declared Zika virus (ZIKV) infection a public health emergency of international concern because it caused congenital Zika syndrome (CZS). The CZS is considered a specific pattern of birth defects caused by ZIKV infection, which is transmitted by the bite of the Aedes aegypti mosquito. The CZS clinical manifestations are broad and nonspecific, including microcephaly, subcortical calcifications, ocular alterations, congenital contractures, early hypertonia, and pyramidal as well as extrapyramidal symptoms. The ZIKV has gained great importance because it has affected a large percentage of the population worldwide during the last few years, despite the measures implemented by international organizations. The pathophysiology and non-vectorial transmission routes of the virus are still under study. The diagnosis is made upon suspicion of ZIKV infection, the patient's clinical manifestations, and it is confirmed by molecular laboratory tests demonstrating the presence of viral particles. Unfortunately, there is no specific treatment or vaccine for this condition; however, patients receive multidisciplinary care and constant monitoring. Therefore, the strategies that have been implemented are directed toward preventive measures and vector control.

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“…During the SARS epidemic, the use of antiviral medications led to a reduction in sperm count, impaired spermatogenesis, and sperm DNA damage or fragmentation (Sengupta and Dutta 2020;de Albuquerque et al 2022). All these changes were sustained for a minimum of 8 months after recovery by treatment.…”

Section: Ace2 Mediated Sars-cov-2 Male Infertilitymentioning

confidence: 99%

Angiotensin Converting Enzyme 2 (ACE2) - A macromolecule and its impact on human reproduction during COVID-19 pandemic

2022

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Coronavirus disease 2019 (COVID 19) is caused by severe acute respiratory syndrome novel coronavirus 2 (SARS-nCoV-2). It has been declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Since then, several researchers have worked/ are working on this virus by a multifactorial approach to finding out the mechanism of entry, transmission route, post-infection replication process, survival, and post-recovery utilities. As we know, SARS, MERS, and Zika viruses have affected human reproductive potentials, consequently, COVID 19 also can affect both men's and women's reproductive potential through ACE2 macromolecule. This study aimed to summarize the role of ACE2- macromolecule in COVID 19 entry and further processes in the reproductive path of both men and women. Research articles were searched in NCBI-NLM, Google Scholar, and Scopus databases. We searched based on the phrase “COVID 19”, “ACE2”, “ACE2 in testes”, “ACE2 in the female reproductive tract”, “ACE2 during pregnancy”, “ACE2 during early embryo”, “COVID 19 and impact in human reproduction” and selected the articles for summarizing this article. Most recent articles and the mechanism of COVID 19 were selected for our understanding. The results of the study revealed that COVID 19 impacts the reproductive potential of both men and women. Testes are the most vulnerable organ prone to infection in men, and vaginal fluid and the uterus could be the choice of infection in the female. Till now, COVID 19 has not been directly detected in semen samples and vaginal fluid. Results of the study can be concluded that ACE2 plays a major role in COVID 19 infection, ACE2 expression could be more in the testes, ovary, uterus, and vagina. COVID 19 could impact more on human reproduction and lead to a loss of fertility status for a while. All antiviral treatments could pose a negative impact on human reproduction. Further research should be carried out on the already existing theoretical hypothesis of SARS-Co-V-2 on human reproduction.

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Human seminal virome: a panel based on recent literature

Cited by 6 publications

References 186 publications

Unraveling the Intricacies of the Seminal Microbiome and Its Impact on Human Fertility

Unraveling the Intricacies of the Seminal Microbiome and Its Impact on Human Fertility

Congenital Zika syndrome

Angiotensin Converting Enzyme 2 (ACE2) - A macromolecule and its impact on human reproduction during COVID-19 pandemic

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