2014
DOI: 10.1016/j.immuni.2014.11.010
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Human RORγt+CD34+ Cells Are Lineage-Specified Progenitors of Group 3 RORγt+ Innate Lymphoid Cells

Abstract: Group 3 innate lymphoid cells (ILC3s) are defined by the expression of the transcription factor RORγt, which is selectively required for their development. The lineage-specified progenitors of ILC3s and their site of development after birth remain undefined. Here we identified a population of human CD34(+) hematopoietic progenitor cells (HPCs) that express RORγt and share a distinct transcriptional signature with ILC3s. RORγt(+)CD34(+) HPCs were located in tonsils and intestinal lamina propria (LP) and selecti… Show more

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Cited by 135 publications
(143 citation statements)
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“…Although much of ILC3 development is thought to take place in this compartment before birth, ILC3 may also develop from adult bone marrow ILCP and immature committed ILC3 precursors have the capacity to migrate from the bone marrow to the periphery where they undergo final maturation 14, 28, 29, 30. Similarly, human adult CD34 + haematopoietic precursor cells have been described that exhibit ROR γ t expression and an ILC3 transcriptional signature,29 while human CD34 + ROR γ t + precursors have been found in adult tonsils and the gut 28, 29, 31. Hence, in addition to the generation of fully committed mature ILC3 subsets during fetal development, further ILC3 maturation of precursors may occur locally in the tissue following birth.…”
Section: Group 3 Innate Lymphoid Cell Developmentmentioning
confidence: 99%
“…Although much of ILC3 development is thought to take place in this compartment before birth, ILC3 may also develop from adult bone marrow ILCP and immature committed ILC3 precursors have the capacity to migrate from the bone marrow to the periphery where they undergo final maturation 14, 28, 29, 30. Similarly, human adult CD34 + haematopoietic precursor cells have been described that exhibit ROR γ t expression and an ILC3 transcriptional signature,29 while human CD34 + ROR γ t + precursors have been found in adult tonsils and the gut 28, 29, 31. Hence, in addition to the generation of fully committed mature ILC3 subsets during fetal development, further ILC3 maturation of precursors may occur locally in the tissue following birth.…”
Section: Group 3 Innate Lymphoid Cell Developmentmentioning
confidence: 99%
“…The development of human ILC and their progenitor(s) are less well characterized. However, recently, the human progenitor of IL‐22 producing ILC3 was described as RORγt + CD34 + hematopoietic stem cells selectively residing in the tonsil and intestinal lamina propria 8.…”
Section: Development and Classification Of Ilc Subsetsmentioning
confidence: 99%
“…Recently, three subsets of ILC have been identified on the basis of their cytokine expression patterns and dependency on transcription factors [14][15][16][17] . Notably, ILC subpopulations produce an array of cytokines that in variety match those of T-helper cell subsets.…”
mentioning
confidence: 99%