Human Rights Implications of Stroke Biobanking and Genomics Research in Sub-Saharan Africa

Adigun, Muyiwa; Ojebuyi, Babatunde Raphael; Akinyemi, Joshua; Wahab, Kolawole; Akpalu, Albert; Owolabi, Lukman; Musbahu, Rabiu; Bello, Abiodun; Obiako, Reginald; Ogunronbi, Mayowa; Singh, Arti; Nichols, Michelle; Jenkins, Carolyn; Jegede, Ayodele Samuel; Kalaria, Rajesh N.; Owolabi, Mayowa; Ovbiagele, Bruce; Arulogun, Oyedunni; Akinyemi, Rufus

doi:10.1163/22131035-11010008

Cited by 3 publications

(3 citation statements)

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“…140 Genetic factors and differing disease profiles, including HIV and tuberculosis, are potential contributors to the early onset of stroke in SSA. [141][142][143] Additionally, The Southern African Stroke Prevention Initiative reports a stark awareness gap about the increased risk of stroke for people with hypertension. 144 Moreover, little is known about the relationship between HDP and stroke in SSA, necessitating further research.…”

Section: Current Researchmentioning

confidence: 99%

Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review

Hahka,

Slotkowski,

Akbar

et al. 2024

Circulation Research

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Hypertension is the leading cause of cardiovascular disease in women, and sub-Saharan African (SSA) countries have some of the highest rates of hypertension in the world. Expanding knowledge of causes, management, and awareness of hypertension and its co-morbidities worldwide is an effective strategy to mitigate its harms, decrease morbidities and mortality, and improve individual quality of life. Hypertensive disorders of pregnancy (HDPs) are a particularly important subset of hypertension, as pregnancy is a major stress test of the cardiovascular system and can be the first instance in which cardiovascular disease is clinically apparent. In SSA, women experience a higher incidence of HDP compared with other African regions. However, the region has yet to adopt treatment and preventative strategies for HDP. This delay stems from insufficient awareness, lack of clinical screening for hypertension, and lack of prevention programs. In this brief literature review, we will address the long-term consequences of hypertension and HDP in women. We evaluate the effects of uncontrolled hypertension in SSA by including research on heart disease, stroke, kidney disease, peripheral arterial disease, and HDP. Limitations exist in the number of studies from SSA; therefore, we will use data from countries across the globe, comparing and contrasting approaches in similar and dissimilar populations. Our review highlights an urgent need to prioritize public health, clinical, and bench research to discover cost-effective preventative and treatment strategies that will improve the lives of women living with hypertension in SSA.

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Section: Current Researchmentioning

confidence: 99%

Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review

Hahka,

Slotkowski,

Akbar

et al. 2024

Circulation Research

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“…[204][205][206][207] In Africa, the Ibadan Brain Ageing, Dementia And Neurodegeneration (IBADAN) brain bank and the African Neurobiobank ELSI Project 205,208 have demonstrated that 19% to 27% of older Africans are willing to donate brains for research and have also drawn attention to the necessity of paying attention to the legal issues related to biobanking in a unique African context. 206,209,210 The Biobank for Aging Studies (BAS) in Sao Paulo, Brazil 204 has shown that 22% of cases with a Clinical Dementia Rating (CDR) score of zero met the criteria for a neuropathological disease diagnosis, with AD being the most common. 21 It has also been shown that VaD and cerebral small vessel disease are higher in Brazil than in other clinicopathological studies.…”

Section: Biobanksmentioning

confidence: 99%

The 2022 symposium on dementia and brain aging in low‐ and middle‐income countries: Highlights on research, diagnosis, care, and impact

Kalaria,

Maestre,

Mahinrad

et al. 2024

Alzheimer's & Dementia

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Two of every three persons living with dementia reside in low‐ and middle‐income countries (LMICs). The projected increase in global dementia rates is expected to affect LMICs disproportionately. However, the majority of global dementia care costs occur in high‐income countries (HICs), with dementia research predominantly focusing on HICs. This imbalance necessitates LMIC‐focused research to ensure that characterization of dementia accurately reflects the involvement and specificities of diverse populations. Development of effective preventive, diagnostic, and therapeutic approaches for dementia in LMICs requires targeted, personalized, and harmonized efforts. Our article represents timely discussions at the 2022 Symposium on Dementia and Brain Aging in LMICs that identified the foremost opportunities to advance dementia research, differential diagnosis, use of neuropsychometric tools, awareness, and treatment options. We highlight key topics discussed at the meeting and provide future recommendations to foster a more equitable landscape for dementia prevention, diagnosis, care, policy, and management in LMICs.Highlights Two‐thirds of persons with dementia live in LMICs, yet research and costs are skewed toward HICs. LMICs expect dementia prevalence to more than double, accompanied by socioeconomic disparities. The 2022 Symposium on Dementia in LMICs addressed advances in research, diagnosis, prevention, and policy. The Nairobi Declaration urges global action to enhance dementia outcomes in LMICs.

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“…(Willis, 2023) reveals that human rights are only part of the most fundamental human right to life. (Adigun et al, 2022) argues that human rights are rights that have been established by national and international legal systems. (Natamiharja et al, 2022) an effort to maintain the security of human existence as a whole through actions that balance the interests of individuals with the common interest.…”

Section: Introductionmentioning

confidence: 99%

Human Rights Studies: A Systematic Literature Review (SLR)

Melani,

Salahudin,

Firdaus

et al. 2024

Jurnal Multidisiplin Indonesia

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This research aims to understand and analyse developments in the study of human rights.The research involves the collection and analysis of data from various sources and literature on human rights. And not limited to academic journals, research articles, reports of international organizations and legal documents. The research method applied to this research is systematic literature review using 145 scientific articles sourced from data scopus. The results of the research reveal that this research seeks to produce a comprehensive and in-depth picture of how human rights studies have evolved and changed over time. The limitation of this research is that the articles used are only sourced from scopus databases so the research findings cannot describe comprehensively about human rights in the world. Further research needs to use scientific articles that come from other reputable international databases, such as the Web of Science and Dimensionds Scholars.

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Human Rights Implications of Stroke Biobanking and Genomics Research in Sub-Saharan Africa

Cited by 3 publications

References 0 publications

Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review

Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review

The 2022 symposium on dementia and brain aging in low‐ and middle‐income countries: Highlights on research, diagnosis, care, and impact

Human Rights Studies: A Systematic Literature Review (SLR)

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