Human Rhinovirus Group C in Hospitalized Children, Singapore

Tan, Boon Huan; Loo, Liat Hui; Lim, Elizabeth Ai-Sim; Seah, Shirley Lay Kheng; Lin, Raymond Tzer‐Pin; Tee, Nancy Wen Sim; Sugrue, Richard J.

doi:10.3201/eid1508.090321

Cited by 18 publications

(16 citation statements)

References 10 publications

(20 reference statements)

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“…In our study, HBoV was detected for the first time in Malaysia in 6 of 165 nasopharyngel aspirates giving a prevalence of 3.6% (Etemadi et al, 2012). The detection rate was comparable to that (3.4%) reported in France (Foulongne et al, 2006b) and Sweden (3.1%) (Allander et al, 2005b) but was lower than that reported (8.0%) in Singapore (Tan et al, 2009).…”

Section: Discussionsupporting

confidence: 64%

Diversity of respiratory viruses detected among hospitalized children with acute lower respiratory tract infections at Hospital Serdang, Malaysia

Etemadi

Jalilian

Othman

et al. 2019

Journal of Virological Methods

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Background: The role of respiratory viruses as the major cause of acute lower respiratory tract infections (ALRTIs) in children is becoming increasingly evident due to the use of sensitive molecular detection methods. The aim of this study was to use conventional and molecular detection methods to assess the epidemiology of respiratory viral infections in children less than five years of age that were hospitalized with ALRTIs. Methods: The cross-sectional study was designed to investigate the occurrence of respiratory viruses including respiratory syncytisl virus (RSV), human metapneumovirus (HMPV), influenza virus A and B (IFV-A and B), parainfluenzavirus 1, 2, 3 and 4 (PIV 1, 2, 3 and 4), human rhinoviruses (HRV), human enterovirus (HEV), human coronaviruses (HCoV) 229E and OC43, human bocavirus (HBoV) and human adenovirus (HAdV) in hospitalized children with ALRTIs, at Hospital Serdang, Malaysia, from June 16 to December 21, 2009. The study was also designed in part to assess the performance of the conventional methods against molecular methods.Results: Viral pathogens were detected in 158 (95.8%) of the patients. Single virus infections were detected in 114 (67.9%) patients; 46 (27.9%) were co-infected with different viruses including double-virus infections in 37 (22.4%) and triple-virus infections in 9 (5.5%) cases. Approximately 70% of samples were found to be positive using conventional methods compared with 96% using molecular methods. A wide range of respiratory viruses were detected in the study. There was a high prevalence of RSV (50.3%) infections, particularly group B viruses. Other etiological agents including HAdV, HMPV, IFV-A, PIV 1-3, HBoV, HCoV-OC43 and HEV were detected in 14. 5, 9.6, 9.1, 4.8, 3.6, 2.4 and 1.8 percent of the samples, respectively. Conclusion: Our results demonstrated the increased sensitivity of molecular detection methods compared with conventional methods for the diagnosis of ARTIs in hospitalized children. This is the first report of HMPV infections in Malaysia.

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Section: Discussionsupporting

confidence: 64%

Diversity of respiratory viruses detected among hospitalized children with acute lower respiratory tract infections at Hospital Serdang, Malaysia

Etemadi

Jalilian

Othman

et al. 2019

Journal of Virological Methods

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“…31 Moreover, in hospitalized children in Singapore, the detection rate of HRV-C was only 3%. 32 These data indicate a variation in HRV-C prevalence in different geographic locations. In addition, as there may be a large number of HRV-C infections that are sub-clinical or do not require hospitalization, further investigations are needed to comprehensively assess the impact of HRV-C infections in adults.…”

Section: Discussionmentioning

confidence: 82%

Human rhinoviruses in Chinese adults with acute respiratory tract infection

Zou

Wang

Xiao

et al. 2010

Journal of Infection

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“…38 On the other hand, HRV-C was found only in 3% of hospitalized children in Singapore which has a tropical climate. 22 Therefore, the timing of the present study during the winter of 2008 may explain the higher detection rate for HRV-C in our study.…”

Section: Discussionmentioning

confidence: 82%